Premorbid childhood ocular alignment abnormalities and adult schizophrenia-spectrum disorder

Jason Schiffman; Justin A Maeda; Kentaro Hayashi; Niels Michelsen; Holger Jelling Sørensen; Morten Ekstrøm; Kylie A Abe; Edward P Chronicle; Sarnoff A Mednick

doi:10.1016/j.schres.2005.08.008

Premorbid childhood ocular alignment abnormalities and adult schizophrenia-spectrum disorder

Jason Schiffman, Justin A Maeda, Kentaro Hayashi, Niels Michelsen, Holger Jelling Sørensen, Morten Ekstrøm, Kylie A Abe, Edward P Chronicle, Sarnoff A Mednick

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

50 Citationer (Scopus)

Abstract

Udgivelsesdato: 2006-Jan-31

Originalsprog	Engelsk
Tidsskrift	Schizophrenia Research
Vol/bind	81
Udgave nummer	2-3
Sider (fra-til)	253-60
Antal sider	7
ISSN	0920-9964
DOI	https://doi.org/10.1016/j.schres.2005.08.008
Status	Udgivet - 2005

Bibliografisk note

Keywords: Adult; Child; Cohort Studies; Female; Follow-Up Studies; Humans; Male; Outcome Assessment (Health Care); Phenotype; Prospective Studies; Risk Factors; Schizophrenia; Schizotypal Personality Disorder; Statistics as Topic; Strabismus; Vision Tests

Adgang til dokumentet

10.1016/j.schres.2005.08.008

Citationsformater

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title = "Premorbid childhood ocular alignment abnormalities and adult schizophrenia-spectrum disorder",

abstract = "This study examined the relation between childhood ocular alignment deficits and adult psychiatric outcomes among children at high-risk for schizophrenia and controls. A sample of 265 Danish children was administered a standardized eye exam assessing strabismus and related ocular alignment deficits. All children whose mothers or fathers had a psychiatric diagnosis of schizophrenia comprised the first group (N=90). Children who had at least one parent with a diagnosis other than schizophrenia comprised the first matched control group (N=93). The second control group consisted of children with no parental diagnoses (N=82). In 1992, adult psychiatric outcome data were obtained for 242 of the original subjects. It was found that children who later developed a schizophrenia-spectrum disorder had significantly higher eye exam scale and strabismus scale scores compared to children who developed other non-psychotic psychopathology and children who did not develop a mental illness. The mean rank for children in the high-risk group (offspring of parents with schizophrenia) on the eye scale and the strabismus scale was greater than the mean rank for children in the matched control groups (both offspring of parents with other non-psychotic disorder and no mental illness), although the results failed to reach statistical significance. Results from this study suggest a premorbid relation between ocular deficits and schizophrenia-spectrum disorders in childhood prior to onset of psychopathology in adulthood. Strabismus may serve as a premorbid marker for spectrum disorders and may have implications for the understanding of early aberrant neurological development related to later schizophrenia-spectrum disorders.",

author = "Jason Schiffman and Maeda, {Justin A} and Kentaro Hayashi and Niels Michelsen and S{\o}rensen, {Holger Jelling} and Morten Ekstr{\o}m and Abe, {Kylie A} and Chronicle, {Edward P} and Mednick, {Sarnoff A}",

note = "Keywords: Adult; Child; Cohort Studies; Female; Follow-Up Studies; Humans; Male; Outcome Assessment (Health Care); Phenotype; Prospective Studies; Risk Factors; Schizophrenia; Schizotypal Personality Disorder; Statistics as Topic; Strabismus; Vision Tests",

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doi = "10.1016/j.schres.2005.08.008",

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T1 - Premorbid childhood ocular alignment abnormalities and adult schizophrenia-spectrum disorder

AU - Schiffman, Jason

AU - Maeda, Justin A

AU - Hayashi, Kentaro

AU - Michelsen, Niels

AU - Sørensen, Holger Jelling

AU - Ekstrøm, Morten

AU - Abe, Kylie A

AU - Chronicle, Edward P

AU - Mednick, Sarnoff A

N1 - Keywords: Adult; Child; Cohort Studies; Female; Follow-Up Studies; Humans; Male; Outcome Assessment (Health Care); Phenotype; Prospective Studies; Risk Factors; Schizophrenia; Schizotypal Personality Disorder; Statistics as Topic; Strabismus; Vision Tests

PY - 2005

Y1 - 2005

N2 - This study examined the relation between childhood ocular alignment deficits and adult psychiatric outcomes among children at high-risk for schizophrenia and controls. A sample of 265 Danish children was administered a standardized eye exam assessing strabismus and related ocular alignment deficits. All children whose mothers or fathers had a psychiatric diagnosis of schizophrenia comprised the first group (N=90). Children who had at least one parent with a diagnosis other than schizophrenia comprised the first matched control group (N=93). The second control group consisted of children with no parental diagnoses (N=82). In 1992, adult psychiatric outcome data were obtained for 242 of the original subjects. It was found that children who later developed a schizophrenia-spectrum disorder had significantly higher eye exam scale and strabismus scale scores compared to children who developed other non-psychotic psychopathology and children who did not develop a mental illness. The mean rank for children in the high-risk group (offspring of parents with schizophrenia) on the eye scale and the strabismus scale was greater than the mean rank for children in the matched control groups (both offspring of parents with other non-psychotic disorder and no mental illness), although the results failed to reach statistical significance. Results from this study suggest a premorbid relation between ocular deficits and schizophrenia-spectrum disorders in childhood prior to onset of psychopathology in adulthood. Strabismus may serve as a premorbid marker for spectrum disorders and may have implications for the understanding of early aberrant neurological development related to later schizophrenia-spectrum disorders.

AB - This study examined the relation between childhood ocular alignment deficits and adult psychiatric outcomes among children at high-risk for schizophrenia and controls. A sample of 265 Danish children was administered a standardized eye exam assessing strabismus and related ocular alignment deficits. All children whose mothers or fathers had a psychiatric diagnosis of schizophrenia comprised the first group (N=90). Children who had at least one parent with a diagnosis other than schizophrenia comprised the first matched control group (N=93). The second control group consisted of children with no parental diagnoses (N=82). In 1992, adult psychiatric outcome data were obtained for 242 of the original subjects. It was found that children who later developed a schizophrenia-spectrum disorder had significantly higher eye exam scale and strabismus scale scores compared to children who developed other non-psychotic psychopathology and children who did not develop a mental illness. The mean rank for children in the high-risk group (offspring of parents with schizophrenia) on the eye scale and the strabismus scale was greater than the mean rank for children in the matched control groups (both offspring of parents with other non-psychotic disorder and no mental illness), although the results failed to reach statistical significance. Results from this study suggest a premorbid relation between ocular deficits and schizophrenia-spectrum disorders in childhood prior to onset of psychopathology in adulthood. Strabismus may serve as a premorbid marker for spectrum disorders and may have implications for the understanding of early aberrant neurological development related to later schizophrenia-spectrum disorders.

U2 - 10.1016/j.schres.2005.08.008

DO - 10.1016/j.schres.2005.08.008

M3 - Journal article

SN - 0920-9964

VL - 81

SP - 253

EP - 260

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 2-3

ER -