Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Breast Cancer Research and Treatment |
| Vol/bind | 113 |
| Udgave nummer | 2 |
| Sider (fra-til) | 339-355 |
| Antal sider | 16 |
| ISSN | 0167-6806 |
| DOI | |
| Status | Udgivet - 2009 |
Bibliografisk note
Keywords: Adolescent; Adult; Aged; Attitude to Health; Breast Neoplasms; Cohort Studies; Comorbidity; Denmark; Depression; Depressive Disorder; Disease Susceptibility; Female; Humans; Mastectomy; Mental Disorders; Middle Aged; Postoperative Period; Prevalence; Questionnaires; Risk Factors; Socioeconomic Factors; Young AdultAdgang til dokumentet
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I: Breast Cancer Research and Treatment, Bind 113, Nr. 2, 2009, s. 339-355.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Prevalence and risk of depressive symptoms 3-4 months post-surgery in a nationwide cohort study of Danish women treated for early stage breast-cancer
AU - Christensen, Søren
AU - Zachariae, Robert
AU - Jensen, Anders Bonde
AU - Vaeth, Michael
AU - Møller, Susanne
AU - Ravnsbaek, Joan
AU - von der Maase, Hans
N1 - Keywords: Adolescent; Adult; Aged; Attitude to Health; Breast Neoplasms; Cohort Studies; Comorbidity; Denmark; Depression; Depressive Disorder; Disease Susceptibility; Female; Humans; Mastectomy; Mental Disorders; Middle Aged; Postoperative Period; Prevalence; Questionnaires; Risk Factors; Socioeconomic Factors; Young Adult
PY - 2009
Y1 - 2009
N2 - BACKGROUND: Elevated levels of depressive symptoms are generally found among cancer patients, but results from existing studies vary considerably with respect to prevalence and proposed risk factors. PURPOSE: To study the prevalence of depressive symptoms and major depression 3-4 months following surgery for breast cancer, and to identify clinical risk factors while adjusting for pre-cancer sociodemographic factors, comorbidity, and psychiatric history. PATIENTS AND METHODS: The study cohort consists of 4917 Danish women, aged 18-70 years, receiving standardized treatment for early stage invasive breast cancer during the 2 1/2 year study period. Of these, 3343 women (68%) participated in a questionnaire study 12-16 weeks following surgery. Depressive symptoms (Beck's Depression Inventory II) and health-related behaviors were assessed by questionnaire. The Danish Breast Cancer Cooperative Group (DBCG) and the surgical departments provided disease-, treatment-, and comorbidity data for the study cohort. Information concerning sociodemographics and psychiatric history were obtained from national longitudinal registries. RESULTS: The results indicated an increased prevalence of depressive symptoms and major depression (13.7%) compared to population-based samples. The pre-cancer variables: Social status, net-wealth, ethnicity, comorbidity, psychiatric history, and age were all independent risk factors for depressive symptoms. Of the clinical variables, only nodal status carried additional prognostic information. Physical functioning, smoking, alcohol use, and BMI were also independently associated with depressive symptoms. CONCLUSION: Risk factors for depressive symptoms were primarily restricted to pre-cancer conditions rather than disease-specific conditions. Special attention should be given to socio-economically deprived women with a history of somatic- and psychiatric disease and poor health behaviors.
AB - BACKGROUND: Elevated levels of depressive symptoms are generally found among cancer patients, but results from existing studies vary considerably with respect to prevalence and proposed risk factors. PURPOSE: To study the prevalence of depressive symptoms and major depression 3-4 months following surgery for breast cancer, and to identify clinical risk factors while adjusting for pre-cancer sociodemographic factors, comorbidity, and psychiatric history. PATIENTS AND METHODS: The study cohort consists of 4917 Danish women, aged 18-70 years, receiving standardized treatment for early stage invasive breast cancer during the 2 1/2 year study period. Of these, 3343 women (68%) participated in a questionnaire study 12-16 weeks following surgery. Depressive symptoms (Beck's Depression Inventory II) and health-related behaviors were assessed by questionnaire. The Danish Breast Cancer Cooperative Group (DBCG) and the surgical departments provided disease-, treatment-, and comorbidity data for the study cohort. Information concerning sociodemographics and psychiatric history were obtained from national longitudinal registries. RESULTS: The results indicated an increased prevalence of depressive symptoms and major depression (13.7%) compared to population-based samples. The pre-cancer variables: Social status, net-wealth, ethnicity, comorbidity, psychiatric history, and age were all independent risk factors for depressive symptoms. Of the clinical variables, only nodal status carried additional prognostic information. Physical functioning, smoking, alcohol use, and BMI were also independently associated with depressive symptoms. CONCLUSION: Risk factors for depressive symptoms were primarily restricted to pre-cancer conditions rather than disease-specific conditions. Special attention should be given to socio-economically deprived women with a history of somatic- and psychiatric disease and poor health behaviors.
U2 - 10.1007/s10549-008-9920-9
DO - 10.1007/s10549-008-9920-9
M3 - Journal article
C2 - 18278553
SN - 0167-6806
VL - 113
SP - 339
EP - 355
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
IS - 2
ER -