Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial

Björn Dahlöf; Peter S Sever; Neil R Poulter; Hans Wedel; D Gareth Beevers; Mark Caulfield; Rory Collins; Sverre E Kjeldsen; Arni Kristinsson; Gordon T McInnes; Jesper Mehlsen; Markku Nieminen; Eoin O'Brien; Jan Ostergren; ASCOT Investigators

doi:10.1016/S0140-6736(05)67185-1

Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial

Björn Dahlöf, Peter S Sever, Neil R Poulter, Hans Wedel, D Gareth Beevers, Mark Caulfield, Rory Collins, Sverre E Kjeldsen, Arni Kristinsson, Gordon T McInnes, Jesper Mehlsen, Markku Nieminen, Eoin O'Brien, Jan Ostergren, ASCOT Investigators

Institut for Klinisk Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

2713 Citationer (Scopus)

Abstract

The apparent shortfall in prevention of coronary heart disease (CHD) noted in early hypertension trials has been attributed to disadvantages of the diuretics and beta blockers used. For a given reduction in blood pressure, some suggested that newer agents would confer advantages over diuretics and beta blockers. Our aim, therefore, was to compare the effect on non-fatal myocardial infarction and fatal CHD of combinations of atenolol with a thiazide versus amlodipine with perindopril.

Originalsprog	Engelsk
Tidsskrift	Lancet
Vol/bind	366
Udgave nummer	9489
Sider (fra-til)	895-906
Antal sider	12
ISSN	0140-6736
DOI	https://doi.org/10.1016/S0140-6736(05)67185-1
Status	Udgivet - sep. 2005

Adgang til dokumentet

10.1016/S0140-6736(05)67185-1

Citationsformater

Dahlöf, B., Sever, P. S., Poulter, N. R., Wedel, H., Beevers, D. G., Caulfield, M., Collins, R., Kjeldsen, S. E., Kristinsson, A., McInnes, G. T., Mehlsen, J., Nieminen, M., O'Brien, E., Ostergren, J., & ASCOT Investigators (2005). Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet, 366(9489), 895-906. https://doi.org/10.1016/S0140-6736(05)67185-1

Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. / Dahlöf, Björn; Sever, Peter S; Poulter, Neil R et al.
I: Lancet, Bind 366, Nr. 9489, 09.2005, s. 895-906.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Dahlöf, B, Sever, PS, Poulter, NR, Wedel, H, Beevers, DG, Caulfield, M, Collins, R, Kjeldsen, SE, Kristinsson, A, McInnes, GT, Mehlsen, J, Nieminen, M, O'Brien, E, Ostergren, J & ASCOT Investigators 2005, 'Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial', Lancet, bind 366, nr. 9489, s. 895-906. https://doi.org/10.1016/S0140-6736(05)67185-1

Dahlöf B, Sever PS, Poulter NR, Wedel H, Beevers DG, Caulfield M et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet. 2005 sep.;366(9489):895-906. doi: 10.1016/S0140-6736(05)67185-1

Dahlöf, Björn ; Sever, Peter S ; Poulter, Neil R et al. / Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. I: Lancet. 2005 ; Bind 366, Nr. 9489. s. 895-906.

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title = "Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial",

abstract = "The apparent shortfall in prevention of coronary heart disease (CHD) noted in early hypertension trials has been attributed to disadvantages of the diuretics and beta blockers used. For a given reduction in blood pressure, some suggested that newer agents would confer advantages over diuretics and beta blockers. Our aim, therefore, was to compare the effect on non-fatal myocardial infarction and fatal CHD of combinations of atenolol with a thiazide versus amlodipine with perindopril.",

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AU - Dahlöf, Björn

AU - Sever, Peter S

AU - Poulter, Neil R

AU - Wedel, Hans

AU - Beevers, D Gareth

AU - Caulfield, Mark

AU - Collins, Rory

AU - Kjeldsen, Sverre E

AU - Kristinsson, Arni

AU - McInnes, Gordon T

AU - Mehlsen, Jesper

AU - Nieminen, Markku

AU - O'Brien, Eoin

AU - Ostergren, Jan

AU - ASCOT Investigators

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AB - The apparent shortfall in prevention of coronary heart disease (CHD) noted in early hypertension trials has been attributed to disadvantages of the diuretics and beta blockers used. For a given reduction in blood pressure, some suggested that newer agents would confer advantages over diuretics and beta blockers. Our aim, therefore, was to compare the effect on non-fatal myocardial infarction and fatal CHD of combinations of atenolol with a thiazide versus amlodipine with perindopril.

U2 - 10.1016/S0140-6736(05)67185-1

DO - 10.1016/S0140-6736(05)67185-1

M3 - Journal article

SN - 0140-6736

VL - 366

SP - 895

EP - 906

JO - Lancet

JF - Lancet

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