Prevention of murine experimental autoimmune orchitis by recombinant human interleukin-6

Lu Li; Masahiro Itoh; Maila Ablake; Battesimo Macrì; Klaus Bendtzen; Ferdinando Nicoletti

doi:http://dx.doi.org/10.1006/clim.2001.5155

Prevention of murine experimental autoimmune orchitis by recombinant human interleukin-6

Lu Li, Masahiro Itoh, Maila Ablake, Battesimo Macrì, Klaus Bendtzen, Ferdinando Nicoletti

Institut for Klinisk Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

16 Citationer (Scopus)

Abstract

We studied the effect of exogenously administered recombinant human interleukin (IL)-6 on the development of experimental autoimmune orchitis (EAO) in C3H/Hej mice. IL-6 significantly reduced histological signs of EAO and appearance of delayed type hypersensitivity against the immunizing testicular germinal cells. The effect was seen even though the cytokine was administered for only 6 consecutive days and 2 weeks after immunization.

Originalsprog	Engelsk
Tidsskrift	Clinical Immunology
Vol/bind	102
Udgave nummer	2
Sider (fra-til)	135-7
Antal sider	3
ISSN	1521-6616
DOI	https://doi.org/10.1006/clim.2001.5155
Status	Udgivet - 1 feb. 2002

Adgang til dokumentet

http://dx.doi.org/10.1006/clim.2001.5155

Citationsformater

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abstract = "We studied the effect of exogenously administered recombinant human interleukin (IL)-6 on the development of experimental autoimmune orchitis (EAO) in C3H/Hej mice. IL-6 significantly reduced histological signs of EAO and appearance of delayed type hypersensitivity against the immunizing testicular germinal cells. The effect was seen even though the cytokine was administered for only 6 consecutive days and 2 weeks after immunization.",

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AU - Li, Lu

AU - Itoh, Masahiro

AU - Ablake, Maila

AU - Macrì, Battesimo

AU - Bendtzen, Klaus

AU - Nicoletti, Ferdinando

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AB - We studied the effect of exogenously administered recombinant human interleukin (IL)-6 on the development of experimental autoimmune orchitis (EAO) in C3H/Hej mice. IL-6 significantly reduced histological signs of EAO and appearance of delayed type hypersensitivity against the immunizing testicular germinal cells. The effect was seen even though the cytokine was administered for only 6 consecutive days and 2 weeks after immunization.

U2 - http://dx.doi.org/10.1006/clim.2001.5155

DO - http://dx.doi.org/10.1006/clim.2001.5155

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