Prevention of taste alterations in patients with cancer receiving Paclitaxel- or Oxaliplatin-based chemotherapy — A pilot trial of cannabidiol

Helena Sylow Heilmann Dominiak*, Simone Dyring Hasselsteen, Sebastian Werngren Nielsen, Jens Rikardt Andersen, Jørn Herrstedt

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

5 Citationer (Scopus)
16 Downloads (Pure)

Abstract

Introduction: Taste alteration is a common adverse effect of chemotherapy. This study aimed to investigate the effect of cannabidiol (CBD) on Lean Body Mass (LBM), and taste alterations during oxaliplatin- or paclitaxel-based chemotherapy. 

Methods: LBM was estimated by bioelectrical impedance analysis (BIA), and taste perception was evaluated by a randomized sensory test of six samples: sweet, salt, and umami, all in weak and strong concentrations. Taste perceptions were scored on visual analog scales. Patients in the intervention group received oral CBD 300 mg/day for 8 days; patients in the control group did not. Patients were followed for three cycles of chemotherapy. 

Results: Twenty-two/ten patients (intervention/control group) were eligible. No effects on LBM were demonstrated. At baseline, the control group was able to differentiate between weak and strong saltiness and weak and strong sweetness but lost this ability after three cycles of chemotherapy. At baseline, the intervention group was unable to differentiate between the concentrations but gained the ability to significantly differentiate between weak and strong sweetness (p = 0.03) and weak and strong saltiness (p = 0.04) after three cycles of chemotherapy and treatment with CBD. 

Conclusions: CBD may improve patients’ ability to differentiate taste strengths during chemotherapy.

OriginalsprogEngelsk
Artikelnummer3014
TidsskriftNutrients
Vol/bind15
Udgave nummer13
Antal sider10
ISSN2072-6643
DOI
StatusUdgivet - 2023

Bibliografisk note

CURIS 2023 NEXS 161

Publisher Copyright:
© 2023 by the authors.

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