Problemer med primakin-recidivprofylakse hos malariapatienter

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    3 Citationer (Scopus)

    Abstract

    Standard treatment of P. ovale and P. vivax malaria is 1500 mg of chloroquine base given over three days followed by 15 mg of primaquine base daily for 14 days. At the Department of Infectious Diseases, Rigshospitalet, Copenhagen an increasing number of cases of relative by primaquine-resistant malaria have been observed. The side effects of primaquine are mainly gastrointestinal. Primaquine may also cause serious toxic side effects, including methaemoglobin formation and haemolytic anaemia, especially in individuals with erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. We present six patients who developed relapses of P. vivax after taking standard doses of primaquine. When increasing primaquine dosage, patients must be informed about the possibility of more severe side effects.
    Bidragets oversatte titel[Recurrence problems with preventive primaquine treatment in patients with malaria]
    OriginalsprogDansk
    TidsskriftUgeskrift for Laeger
    Vol/bind155
    Udgave nummer48
    Sider (fra-til)3901-4
    Antal sider4
    ISSN0041-5782
    StatusUdgivet - 29 nov. 1993

    Emneord

    • Adult
    • Drug Resistance, Microbial
    • Gastrointestinal Diseases
    • Humans
    • Malaria, Falciparum
    • Malaria, Vivax
    • Male
    • Middle Aged
    • Primaquine
    • Recurrence

    Citationsformater