@article{db8ce0951f05445dbb1a8344a8b03f1e,
title = "Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial",
abstract = "For patients in intensive care units, sepsis is a common and potentially deadly complication and prompt initiation of appropriate antimicrobial therapy improves prognosis. The objective of this trial was to determine whether a strategy of antimicrobial spectrum escalation, guided by daily measurements of the biomarker procalcitonin, could reduce the time to appropriate therapy, thus improving survival.",
keywords = "Aged, Algorithms, Anti-Bacterial Agents, Biological Markers, Calcitonin, Female, Hospital Mortality, Humans, Intensive Care Units, Length of Stay, Male, Middle Aged, Protein Precursors, Respiration, Artificial, Sepsis, Time Factors",
author = "Jensen, {Jens U} and Lars Hein and Bettina Lundgren and Bestle, {Morten H} and Mohr, {Thomas T} and Andersen, {Mads H} and Thornberg, {Klaus J} and Jesper L{\o}ken and Morten Steensen and Zoe Fox and Hamid Tousi and Peter S{\o}e-Jensen and Lauritsen, {Anne {\O}} and Ditte Strange and Petersen, {Pernille L} and Nanna Reiter and S{\o}ren Hestad and Katrin Thormar and Paul Fjeldborg and Larsen, {Kim M} and Drenck, {Niels E} and Christian Ostergaard and Jesper Kj{\ae}r and Jesper Grarup and Lundgren, {Jens D} and {Procalcitonin And Survival Study (PASS) Group} and Pedersen, {Lars M{\o}ller}",
year = "2011",
month = sep,
day = "1",
doi = "10.1097/CCM.0b013e31821e8791",
language = "English",
volume = "39",
pages = "2048--58",
journal = "Critical Care Medicine",
issn = "0090-3493",
publisher = "Lippincott Williams & Wilkins",
number = "9",
}