Proceedings from the Albert Charitable Trust Inaugural Workshop on white matter and cognition in aging

Farzaneh A. Sorond*, Shawn Whitehead, Ken Arai, Douglas Arnold, S. Thomas Carmichael, Charles De Carli, Marco Duering, Myriam Fornage, Rafael E. Flores-Obando, Jonathan Graff-Radford, Edith Hamel, David C. Hess, Massafumi Ihara, Majken K. Jensen, Hugh S. Markus, Axel Montagne, Gary Rosenberg, Andy Y. Shih, Eric E. Smith, Alex ThielKai Hei Tse, Donna Wilcock, Frank Barone

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftReviewForskningpeer review

4 Citationer (Scopus)

Abstract

This third in a series of vascular cognitive impairment (VCI) workshops, supported by “The Leo and Anne Albert Charitable Trust,” was held from February 8 to 12 at the Omni Resort in Carlsbad, CA. This workshop followed the information gathered from the earlier two workshops suggesting that we focus more specifically on brain white matter in age-related cognitive impairment. The Scientific Program Committee (Frank Barone, Shawn Whitehead, Eric Smith, and Rod Corriveau) assembled translational, clinical, and basic scientists with unique expertise in acute and chronic white matter injury at the intersection of cerebrovascular and neurodegenerative etiologies. As in previous Albert Trust workshops, invited participants addressed key topics related to mechanisms of white matter injury, biomarkers of white matter injury, and interventions to prevent white matter injury and age-related cognitive decline. This report provides a synopsis of the presentations and discussions by the participants, including the existing knowledge gaps and the delineation of the next steps towards advancing our understanding of white matter injury and age-related cognitive decline. Workshop discussions and consensus resulted in action by The Albert Trust to (1) increase support from biannual to annual “White Matter and Cognition” workshops; (2) provide funding for two collaborative, novel research grants annually submitted by meeting participants; and (3) coordinate the formation of the “Albert Research Institute for White Matter and Cognition.” This institute will fill a gap in white matter science, providing white matter and cognition communications, including annual updates from workshops and the literature and interconnecting with other Albert Trust scientific endeavors in cognition and dementia, and providing support for newly established collaborations between seasoned investigators and to the development of talented young investigators in the VCI-dementia (VCID) and white matter cognition arena.

OriginalsprogEngelsk
TidsskriftGeroScience
Vol/bind42
Udgave nummer1
Sider (fra-til)81-96
Antal sider16
ISSN2509-2715
DOI
StatusUdgivet - 2020
Udgivet eksterntJa

Bibliografisk note

Funding Information:
This was the third of biannual VCI and dementia translational workshops provided by the generosity of the Leo and Anne Albert Charitable Trust. It is very special in that it has been built from the first two workshops to fill a knowledge gap and focus into workshops on “White Matter and Cognition” to advance knowledge of white matter pathology and mechanisms of cognitive loss that occurs in cerebrovascular and neurodegenerative diseases. Initiatives set forth from this workshop include the following: “White Matter and Cognition” workshops will be now held annually instead of biannually. The “Albert Trust Research Institute for White Matter and Cognition” was incorporated to facilitate white matter science and communication and to translate white matter disease biology into treatments that can reduce the horrific future projects for dementia in the aging world population. Two annual collaborative research grants submitted by participants that had not previously worked together will be funded by the Albert Trust. The next (forth) annual workshop is planned for April 2020 in San Antonio, TX, and the Scientific Program Committee Members have started working on the scientific program.

Publisher Copyright:
© 2019, American Aging Association.

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