Progestogens to prevent preterm birth in twin pregnancies: an individual participant data meta-analysis of randomized trials

Ewoud Schuit; Sarah Stock; Rolf H H Groenwold; Kimberly Maurel; C Andrew Combs; Thomas Garite; Cathy Y Spong; Elizabeth A Thom; Dwight J Rouse; Steve N Caritis; George R Saade; Julia M Zachary; Jane E Norman; Line Rode; Katharina Klein; Ann Tabor; Elçin Cetingöz; John C Morrison; Everett F Magann; Christian M Briery; Vicente Serra; Alfredo Perales; Juan Meseguer; Anwar H Nassar; Arianne C Lim; Karel G M Moons; Anneke Kwee; Ben Willem J Mol

doi:10.1186/1471-2393-12-13

Progestogens to prevent preterm birth in twin pregnancies: an individual participant data meta-analysis of randomized trials

Ewoud Schuit, Sarah Stock, Rolf H H Groenwold, Kimberly Maurel, C Andrew Combs, Thomas Garite, Cathy Y Spong, Elizabeth A Thom, Dwight J Rouse, Steve N Caritis, George R Saade, Julia M Zachary, Jane E Norman, Line Rode, Katharina Klein, Ann Tabor, Elçin Cetingöz, John C Morrison, Everett F Magann, Christian M BrieryVicente Serra, Alfredo Perales, Juan Meseguer, Anwar H Nassar, Arianne C Lim, Karel G M Moons, Anneke Kwee, Ben Willem J Mol

Institut for Klinisk Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

15 Citationer (Scopus)

Abstract

Preterm birth is the principal factor contributing to adverse outcomes in multiple pregnancies. Randomized controlled trials of progestogens to prevent preterm birth in twin pregnancies have shown no clear benefits. However, individual studies have not had sufficient power to evaluate potential benefits in women at particular high risk of early delivery (for example, women with a previous preterm birth or short cervix) or to determine adverse effects for rare outcomes such as intrauterine death.

Originalsprog	Engelsk
Tidsskrift	B M C Pregnancy and Childbirth
Vol/bind	12
Sider (fra-til)	13
ISSN	1471-2393
DOI	https://doi.org/10.1186/1471-2393-12-13
Status	Udgivet - 2012

Adgang til dokumentet

10.1186/1471-2393-12-13

Citationsformater

Schuit, E., Stock, S., Groenwold, R. H. H., Maurel, K., Combs, C. A., Garite, T., Spong, C. Y., Thom, E. A., Rouse, D. J., Caritis, S. N., Saade, G. R., Zachary, J. M., Norman, J. E., Rode, L., Klein, K., Tabor, A., Cetingöz, E., Morrison, J. C., Magann, E. F., ... Mol, B. W. J. (2012). Progestogens to prevent preterm birth in twin pregnancies: an individual participant data meta-analysis of randomized trials. B M C Pregnancy and Childbirth, 12, 13. https://doi.org/10.1186/1471-2393-12-13

Schuit, E, Stock, S, Groenwold, RHH, Maurel, K, Combs, CA, Garite, T, Spong, CY, Thom, EA, Rouse, DJ, Caritis, SN, Saade, GR, Zachary, JM, Norman, JE, Rode, L, Klein, K, Tabor, A, Cetingöz, E, Morrison, JC, Magann, EF, Briery, CM, Serra, V, Perales, A, Meseguer, J, Nassar, AH, Lim, AC, Moons, KGM, Kwee, A & Mol, BWJ 2012, 'Progestogens to prevent preterm birth in twin pregnancies: an individual participant data meta-analysis of randomized trials', B M C Pregnancy and Childbirth, bind 12, s. 13. https://doi.org/10.1186/1471-2393-12-13

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title = "Progestogens to prevent preterm birth in twin pregnancies: an individual participant data meta-analysis of randomized trials",

abstract = "Preterm birth is the principal factor contributing to adverse outcomes in multiple pregnancies. Randomized controlled trials of progestogens to prevent preterm birth in twin pregnancies have shown no clear benefits. However, individual studies have not had sufficient power to evaluate potential benefits in women at particular high risk of early delivery (for example, women with a previous preterm birth or short cervix) or to determine adverse effects for rare outcomes such as intrauterine death.",

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T1 - Progestogens to prevent preterm birth in twin pregnancies

T2 - an individual participant data meta-analysis of randomized trials

AU - Schuit, Ewoud

AU - Stock, Sarah

AU - Groenwold, Rolf H H

AU - Maurel, Kimberly

AU - Combs, C Andrew

AU - Garite, Thomas

AU - Spong, Cathy Y

AU - Thom, Elizabeth A

AU - Rouse, Dwight J

AU - Caritis, Steve N

AU - Saade, George R

AU - Zachary, Julia M

AU - Norman, Jane E

AU - Rode, Line

AU - Klein, Katharina

AU - Tabor, Ann

AU - Cetingöz, Elçin

AU - Morrison, John C

AU - Magann, Everett F

AU - Briery, Christian M

AU - Serra, Vicente

AU - Perales, Alfredo

AU - Meseguer, Juan

AU - Nassar, Anwar H

AU - Lim, Arianne C

AU - Moons, Karel G M

AU - Kwee, Anneke

AU - Mol, Ben Willem J

PY - 2012

Y1 - 2012

N2 - Preterm birth is the principal factor contributing to adverse outcomes in multiple pregnancies. Randomized controlled trials of progestogens to prevent preterm birth in twin pregnancies have shown no clear benefits. However, individual studies have not had sufficient power to evaluate potential benefits in women at particular high risk of early delivery (for example, women with a previous preterm birth or short cervix) or to determine adverse effects for rare outcomes such as intrauterine death.

AB - Preterm birth is the principal factor contributing to adverse outcomes in multiple pregnancies. Randomized controlled trials of progestogens to prevent preterm birth in twin pregnancies have shown no clear benefits. However, individual studies have not had sufficient power to evaluate potential benefits in women at particular high risk of early delivery (for example, women with a previous preterm birth or short cervix) or to determine adverse effects for rare outcomes such as intrauterine death.

KW - Adult

KW - Clinical Protocols

KW - Female

KW - Humans

KW - Infant, Newborn

KW - Models, Statistical

KW - Pregnancy

KW - Pregnancy Complications

KW - Pregnancy Outcome

KW - Pregnancy, Twin

KW - Premature Birth

KW - Progestins

KW - Randomized Controlled Trials as Topic

U2 - 10.1186/1471-2393-12-13

DO - 10.1186/1471-2393-12-13

M3 - Journal article

C2 - 22420582

SN - 1471-2393

VL - 12

SP - 13

JO - B M C Pregnancy and Childbirth

JF - B M C Pregnancy and Childbirth

ER -