TY - JOUR
T1 - Prognostic importance of pulmonary hypertension in patients with heart failure
AU - Kjaergaard, Jesper
AU - Akkan, Dilek
AU - Iversen, Kasper Karmark
AU - Kjoller, Erik
AU - Køber, Lars
AU - Torp-Pedersen, Christian
AU - Hassager, Christian
N1 - Keywords: Age Factors; Aged; Aged, 80 and over; Cardiac Output, Low; Diabetes Complications; Echocardiography, Doppler; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Kidney Diseases; Male; Prognosis; Prospective Studies; Pulmonary Disease, Chronic Obstructive; Pulmonary Wedge Pressure; Risk Assessment; Smoking; Stroke Volume; Survival Rate; Ventricular Pressure
PY - 2007
Y1 - 2007
N2 - Pulmonary hypertension is a well-known complication in heart failure, but its prognostic importance is less well established. This study assessed the risk associated with pulmonary hypertension in patients with heart failure with preserved or reduced left ventricular (LV) ejection fractions. Patients with known or presumed heart failure (n = 388) underwent the echocardiographic assessment of pulmonary systolic pressure and LV ejection fraction. Patients were followed for up to 5.5 years. Increased pulmonary pressure was associated with increased short- and long-term mortality (p <0.0001 and p = 0.003, respectively). This relation was also present when stratifying patients by reduced or preserved LV function. A Cox proportional-hazards model apportioned a 9% increase in mortality per 5 mm Hg increase in right ventricular systolic pressure (p = 0.0008), independent of age and known chronic obstructive lung disease, heart failure, and impaired renal function. In conclusion, pulmonary hypertension is associated with increased short- and long-term mortality in patients with reduced LV ejection fractions and also in patients with preserved LV ejection fractions.
AB - Pulmonary hypertension is a well-known complication in heart failure, but its prognostic importance is less well established. This study assessed the risk associated with pulmonary hypertension in patients with heart failure with preserved or reduced left ventricular (LV) ejection fractions. Patients with known or presumed heart failure (n = 388) underwent the echocardiographic assessment of pulmonary systolic pressure and LV ejection fraction. Patients were followed for up to 5.5 years. Increased pulmonary pressure was associated with increased short- and long-term mortality (p <0.0001 and p = 0.003, respectively). This relation was also present when stratifying patients by reduced or preserved LV function. A Cox proportional-hazards model apportioned a 9% increase in mortality per 5 mm Hg increase in right ventricular systolic pressure (p = 0.0008), independent of age and known chronic obstructive lung disease, heart failure, and impaired renal function. In conclusion, pulmonary hypertension is associated with increased short- and long-term mortality in patients with reduced LV ejection fractions and also in patients with preserved LV ejection fractions.
U2 - 10.1016/j.amjcard.2006.11.052
DO - 10.1016/j.amjcard.2006.11.052
M3 - Journal article
C2 - 17437745
VL - 99
SP - 1146
EP - 1150
JO - Am. J. Cardiol.
JF - Am. J. Cardiol.
SN - 0002-9149
IS - 8
ER -