Programming strategy for efficient modeling of dynamics in a population of heterogeneous cells

Bjørn Olav Hald; Morten Hendriksen; Preben Graae Sørensen

doi:10.1093/bioinformatics/btt132

Programming strategy for efficient modeling of dynamics in a population of heterogeneous cells

Bjørn Olav Hald, Morten Hendriksen, Preben Graae Sørensen

Kemisk Institut

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

9 Citationer (Scopus)

Abstract

Heterogeneity is a ubiquitous property of biological systems. Even in a genetically identical population of a single cell type, cell-to-cell differences are observed. Although the functional behavior of a given population is generally robust, the consequences of heterogeneity are fairly unpredictable. In heterogeneous populations, synchronization of events becomes a cardinal problem-particularly for phase coherence in oscillating systems.

Originalsprog	Engelsk
Tidsskrift	Bioinformatics
Vol/bind	29
Udgave nummer	10
Sider (fra-til)	1292-1298
Antal sider	7
ISSN	1367-4803
DOI	https://doi.org/10.1093/bioinformatics/btt132
Status	Udgivet - 2013

Emneord

Det Sundhedsvidenskabelige Fakultet

Adgang til dokumentet

10.1093/bioinformatics/btt132

Citationsformater

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abstract = "Heterogeneity is a ubiquitous property of biological systems. Even in a genetically identical population of a single cell type, cell-to-cell differences are observed. Although the functional behavior of a given population is generally robust, the consequences of heterogeneity are fairly unpredictable. In heterogeneous populations, synchronization of events becomes a cardinal problem-particularly for phase coherence in oscillating systems.",

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AU - Hald, Bjørn Olav

AU - Hendriksen, Morten

AU - Sørensen, Preben Graae

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N2 - Heterogeneity is a ubiquitous property of biological systems. Even in a genetically identical population of a single cell type, cell-to-cell differences are observed. Although the functional behavior of a given population is generally robust, the consequences of heterogeneity are fairly unpredictable. In heterogeneous populations, synchronization of events becomes a cardinal problem-particularly for phase coherence in oscillating systems.

AB - Heterogeneity is a ubiquitous property of biological systems. Even in a genetically identical population of a single cell type, cell-to-cell differences are observed. Although the functional behavior of a given population is generally robust, the consequences of heterogeneity are fairly unpredictable. In heterogeneous populations, synchronization of events becomes a cardinal problem-particularly for phase coherence in oscillating systems.

KW - Faculty of Health and Medical Sciences

U2 - 10.1093/bioinformatics/btt132

DO - 10.1093/bioinformatics/btt132

M3 - Journal article

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JO - Computer Applications in the Biosciences

JF - Computer Applications in the Biosciences

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