Prolongation of bleeding time and inhibition of platelet aggregation by low-dose acetylsalicylic acid in patients with cerebrovascular disease

G Boysen; A H Boss; Niels Ødum; J S Olsen

Prolongation of bleeding time and inhibition of platelet aggregation by low-dose acetylsalicylic acid in patients with cerebrovascular disease

G Boysen, A H Boss, Niels Ødum, J S Olsen

Cellebiologi og Fysiologi

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

28 Citationer (Scopus)

Abstract

Udgivelsesdato: null-null

Originalsprog	Engelsk
Tidsskrift	Stroke
Vol/bind	15
Udgave nummer	2
Sider (fra-til)	241-3
Antal sider	2
ISSN	0039-2499
Status	Udgivet - 1984

Bibliografisk note

Keywords: Aged; Aspirin; Bleeding Time; Cerebrovascular Disorders; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Placebos; Platelet Aggregation; Platelet Function Tests; Random Allocation

Citationsformater

@article{71711350fda511ddb219000ea68e967b,

title = "Prolongation of bleeding time and inhibition of platelet aggregation by low-dose acetylsalicylic acid in patients with cerebrovascular disease",

abstract = "Platelet aggregation and bleeding time was measured in 43 cerebrovascular patients participating in a controlled double-blind study of low-dose acetylsalicylic acid. In 19 patients with satisfactory inhibition of the platelet aggregation obtained by 50 to 70 mg acetylsalicylic acid per day the bleeding time averaged 11.2 minutes in contrast to 7.0 minutes in the placebo group, p less than 0.001. This study confirms our previous findings of platelet inhibition by low-dose acetylsalicylic acid in patients with cerebrovascular disease. The prolongation of the bleeding time demonstrates that we are dealing not merely with an in vitro phenomenon but with a significant in vivo effect. The study provides the rationale for clinical evaluations of low-dose acetylsalicylic acid in stroke prophylaxis.",

author = "G Boysen and Boss, {A H} and Niels {\O}dum and Olsen, {J S}",

note = "Keywords: Aged; Aspirin; Bleeding Time; Cerebrovascular Disorders; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Placebos; Platelet Aggregation; Platelet Function Tests; Random Allocation",

year = "1984",

language = "English",

volume = "15",

pages = "241--3",

journal = "Stroke",

issn = "0039-2499",

publisher = "Lippincott Williams & Wilkins",

number = "2",

}

TY - JOUR

T1 - Prolongation of bleeding time and inhibition of platelet aggregation by low-dose acetylsalicylic acid in patients with cerebrovascular disease

AU - Boysen, G

AU - Boss, A H

AU - Ødum, Niels

AU - Olsen, J S

N1 - Keywords: Aged; Aspirin; Bleeding Time; Cerebrovascular Disorders; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Placebos; Platelet Aggregation; Platelet Function Tests; Random Allocation

PY - 1984

Y1 - 1984

N2 - Platelet aggregation and bleeding time was measured in 43 cerebrovascular patients participating in a controlled double-blind study of low-dose acetylsalicylic acid. In 19 patients with satisfactory inhibition of the platelet aggregation obtained by 50 to 70 mg acetylsalicylic acid per day the bleeding time averaged 11.2 minutes in contrast to 7.0 minutes in the placebo group, p less than 0.001. This study confirms our previous findings of platelet inhibition by low-dose acetylsalicylic acid in patients with cerebrovascular disease. The prolongation of the bleeding time demonstrates that we are dealing not merely with an in vitro phenomenon but with a significant in vivo effect. The study provides the rationale for clinical evaluations of low-dose acetylsalicylic acid in stroke prophylaxis.

AB - Platelet aggregation and bleeding time was measured in 43 cerebrovascular patients participating in a controlled double-blind study of low-dose acetylsalicylic acid. In 19 patients with satisfactory inhibition of the platelet aggregation obtained by 50 to 70 mg acetylsalicylic acid per day the bleeding time averaged 11.2 minutes in contrast to 7.0 minutes in the placebo group, p less than 0.001. This study confirms our previous findings of platelet inhibition by low-dose acetylsalicylic acid in patients with cerebrovascular disease. The prolongation of the bleeding time demonstrates that we are dealing not merely with an in vitro phenomenon but with a significant in vivo effect. The study provides the rationale for clinical evaluations of low-dose acetylsalicylic acid in stroke prophylaxis.

M3 - Journal article

C2 - 6367153

SN - 0039-2499

VL - 15

SP - 241

EP - 243

JO - Stroke

JF - Stroke

IS - 2

ER -