Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects

Kaspar Rosengreen Nielsen; Rudi Nora Steffensen; Martin Boegsted; John Baech; Soeren Lundbye-Christensen; Merete L Hetland; Sophine B Krintel; Hans E. Johnsen; Mette Nyegaard; Julia S Johansen

doi:http://dx.doi.org/10.1186/ar3391

Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects

Kaspar Rosengreen Nielsen, Rudi Nora Steffensen, Martin Boegsted, John Baech, Soeren Lundbye-Christensen, Merete L Hetland, Sophine B Krintel, Hans E. Johnsen, Mette Nyegaard, Julia S Johansen

Ph.d.-studienævnet for Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

40 Citationer (Scopus)

Abstract

The present study investigates the association between single nucleotide polymorphisms (SNPs) in the chitinase 3-like 1 (CHI3L1) gene and serum concentrations of YKL-40 in Danish patients with rheumatoid arthritis (RA) and healthy controls as well as the association with RA in the Danish population. The CHI3L1 gene is located on chromosome 1q32.1 and encodes the YKL-40 glycoprotein. YKL-40 concentrations are elevated in the serum of patients with RA compared to healthy subjects, and YKL-40 has been suggested to be an auto-antigen and may play a role in development of RA and in inflammation.

Originalsprog	Engelsk
Tidsskrift	Arthritis Research & Therapy
Vol/bind	13
Udgave nummer	3
Sider (fra-til)	R109
Antal sider	13
ISSN	1478-6362
DOI	https://doi.org/10.1186/ar3391
Status	Udgivet - 2011

Adgang til dokumentet

http://dx.doi.org/10.1186/ar3391

Citationsformater

Nielsen, K. R., Steffensen, R. N., Boegsted, M., Baech, J., Lundbye-Christensen, S., Hetland, M. L., Krintel, S. B., Johnsen, H. E., Nyegaard, M., & Johansen, J. S. (2011). Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects. Arthritis Research & Therapy, 13(3), R109. https://doi.org/10.1186/ar3391

Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects. / Nielsen, Kaspar Rosengreen; Steffensen, Rudi Nora; Boegsted, Martin; Baech, John; Lundbye-Christensen, Soeren; Hetland, Merete L; Krintel, Sophine B; Johnsen, Hans E.; Nyegaard, Mette; Johansen, Julia S.

I: Arthritis Research & Therapy, Bind 13, Nr. 3, 2011, s. R109.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Nielsen, KR, Steffensen, RN, Boegsted, M, Baech, J, Lundbye-Christensen, S, Hetland, ML, Krintel, SB, Johnsen, HE, Nyegaard, M & Johansen, JS 2011, 'Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects', Arthritis Research & Therapy, bind 13, nr. 3, s. R109. https://doi.org/10.1186/ar3391

Nielsen, Kaspar Rosengreen ; Steffensen, Rudi Nora ; Boegsted, Martin ; Baech, John ; Lundbye-Christensen, Soeren ; Hetland, Merete L ; Krintel, Sophine B ; Johnsen, Hans E. ; Nyegaard, Mette ; Johansen, Julia S. / Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects. I: Arthritis Research & Therapy. 2011 ; Bind 13, Nr. 3. s. R109.

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abstract = "The present study investigates the association between single nucleotide polymorphisms (SNPs) in the chitinase 3-like 1 (CHI3L1) gene and serum concentrations of YKL-40 in Danish patients with rheumatoid arthritis (RA) and healthy controls as well as the association with RA in the Danish population. The CHI3L1 gene is located on chromosome 1q32.1 and encodes the YKL-40 glycoprotein. YKL-40 concentrations are elevated in the serum of patients with RA compared to healthy subjects, and YKL-40 has been suggested to be an auto-antigen and may play a role in development of RA and in inflammation.",

author = "Nielsen, {Kaspar Rosengreen} and Steffensen, {Rudi Nora} and Martin Boegsted and John Baech and Soeren Lundbye-Christensen and Hetland, {Merete L} and Krintel, {Sophine B} and Johnsen, {Hans E.} and Mette Nyegaard and Johansen, {Julia S}",

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AU - Nielsen, Kaspar Rosengreen

AU - Steffensen, Rudi Nora

AU - Boegsted, Martin

AU - Baech, John

AU - Lundbye-Christensen, Soeren

AU - Hetland, Merete L

AU - Krintel, Sophine B

AU - Johnsen, Hans E.

AU - Nyegaard, Mette

AU - Johansen, Julia S

PY - 2011

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N2 - The present study investigates the association between single nucleotide polymorphisms (SNPs) in the chitinase 3-like 1 (CHI3L1) gene and serum concentrations of YKL-40 in Danish patients with rheumatoid arthritis (RA) and healthy controls as well as the association with RA in the Danish population. The CHI3L1 gene is located on chromosome 1q32.1 and encodes the YKL-40 glycoprotein. YKL-40 concentrations are elevated in the serum of patients with RA compared to healthy subjects, and YKL-40 has been suggested to be an auto-antigen and may play a role in development of RA and in inflammation.

AB - The present study investigates the association between single nucleotide polymorphisms (SNPs) in the chitinase 3-like 1 (CHI3L1) gene and serum concentrations of YKL-40 in Danish patients with rheumatoid arthritis (RA) and healthy controls as well as the association with RA in the Danish population. The CHI3L1 gene is located on chromosome 1q32.1 and encodes the YKL-40 glycoprotein. YKL-40 concentrations are elevated in the serum of patients with RA compared to healthy subjects, and YKL-40 has been suggested to be an auto-antigen and may play a role in development of RA and in inflammation.

U2 - http://dx.doi.org/10.1186/ar3391

DO - http://dx.doi.org/10.1186/ar3391

M3 - Journal article

VL - 13

SP - R109

JO - Arthritis Research & Therapy

JF - Arthritis Research & Therapy

SN - 1478-6354

IS - 3

ER -