TY - JOUR
T1 - Protein kinase C {alpha} activity is important for contraction-induced FXYD1 phosphorylation in skeletal muscle
AU - Thomassen, Martin
AU - Rose, Adam John
AU - Jensen, Thomas Elbenhardt
AU - Maarbjerg, Stine Just
AU - Bune, Laurids Touborg
AU - Leitges, Michael
AU - Richter, Erik A.
AU - Bangsbo, Jens
AU - Nordsborg, Nikolai Baastrup
N1 - CURIS 2011 5200 118
PY - 2011
Y1 - 2011
N2 - Exercise induced phosphorylation of FXYD1 is a potential important regulator of Na(+), K(+) pump activity. It was investigated if skeletal muscle contractions induce phosphorylation of FXYD1 and if Protein Kinase C a (PKCa) activity is a prerequisite for this possible mechanism. In part 1, human muscle biopsies were obtained at rest, after 30 s of high intensity exercise (166±31% of VO(2max)) and after a subsequent 20 min of moderate intensity exercise (79±8% of VO(2max)). In general, FXYD1 phosphorylation was increased compared to rest both after 30 s (P
AB - Exercise induced phosphorylation of FXYD1 is a potential important regulator of Na(+), K(+) pump activity. It was investigated if skeletal muscle contractions induce phosphorylation of FXYD1 and if Protein Kinase C a (PKCa) activity is a prerequisite for this possible mechanism. In part 1, human muscle biopsies were obtained at rest, after 30 s of high intensity exercise (166±31% of VO(2max)) and after a subsequent 20 min of moderate intensity exercise (79±8% of VO(2max)). In general, FXYD1 phosphorylation was increased compared to rest both after 30 s (P
U2 - 10.1152/ajpregu.00066.2011
DO - 10.1152/ajpregu.00066.2011
M3 - Journal article
C2 - 21957166
VL - 301
SP - R1808-R1814
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6119
IS - 6
ER -