TY - JOUR
T1 - Psychosocial factors associated with quality of life in cancer patients undergoing treatment
T2 - an umbrella review
AU - Marzorati, Chiara
AU - Voskanyan, Viktorya
AU - Sala, Diana
AU - Grasso, Roberto
AU - Borgogni, Federico
AU - Pietrobon, Ricardo
AU - van der Heide, Iris
AU - Engelaar, Merel
AU - Bos, Nanne
AU - Caraceni, Augusto
AU - Couspel, Norbert
AU - Ferrer, Montse
AU - Groenvold, Mogens
AU - Kaasa, Stein
AU - Lombardo, Claudio
AU - Sirven, Aude
AU - Vachon, Hugo
AU - Gilbert, Alexandra
AU - Brunelli, Cinzia
AU - Apolone, Giovanni
AU - Pravettoni, Gabriella
AU - EUonQoL Consortium
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025
Y1 - 2025
N2 - Background: Cancer treatment greatly impacts physical and psychological functioning of cancer patients, negatively affecting their quality of life (QoL). This Umbrella Review (UR) aims to systematically summarize psychological and social factors positively or negatively associated with QoL in cancer patients undergoing treatment. Method: Four scientific databases (PubMed, Embase, Scopus, and PsycInfo) were searched to identify systematic reviews between 2012 and 2023 analyzing the relationship between QoL and psychosocial factors in cancer patients in treatment. The UR was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Joanna Briggs Institute (JBI) review guidelines. The methodological quality of the included studies was evaluated using Assessment of Multiple Systematic Reviews 2 (AMSTAR2). Results: Eighteen systematic reviews were included. The major psychological factors influencing QoL are depression, coping strategies, anxiety, and distress. Results also demonstrate the significant impact of social factors on QoL: perceived social support has a positive influence on QoL of cancer patients, while lowered social support, impaired social functioning, interactions, and role limitations worsen their QoL and overall well-being. Conclusion: This UR provides a comprehensive overview of the psychosocial factors impacting QoL of cancer patients and serves as a prominent base for developing questionnaires and policies aimed at measuring QoL in cancer patients undergoing treatment. Moreover, the findings of the study can guide future research or the development of personalized clinical interventions aimed at improving QoL for this cancer population group.
AB - Background: Cancer treatment greatly impacts physical and psychological functioning of cancer patients, negatively affecting their quality of life (QoL). This Umbrella Review (UR) aims to systematically summarize psychological and social factors positively or negatively associated with QoL in cancer patients undergoing treatment. Method: Four scientific databases (PubMed, Embase, Scopus, and PsycInfo) were searched to identify systematic reviews between 2012 and 2023 analyzing the relationship between QoL and psychosocial factors in cancer patients in treatment. The UR was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Joanna Briggs Institute (JBI) review guidelines. The methodological quality of the included studies was evaluated using Assessment of Multiple Systematic Reviews 2 (AMSTAR2). Results: Eighteen systematic reviews were included. The major psychological factors influencing QoL are depression, coping strategies, anxiety, and distress. Results also demonstrate the significant impact of social factors on QoL: perceived social support has a positive influence on QoL of cancer patients, while lowered social support, impaired social functioning, interactions, and role limitations worsen their QoL and overall well-being. Conclusion: This UR provides a comprehensive overview of the psychosocial factors impacting QoL of cancer patients and serves as a prominent base for developing questionnaires and policies aimed at measuring QoL in cancer patients undergoing treatment. Moreover, the findings of the study can guide future research or the development of personalized clinical interventions aimed at improving QoL for this cancer population group.
KW - Cancer
KW - Cancer Patients
KW - Psychosocial factors
KW - Quality of Life
KW - Umbrella Review
U2 - 10.1186/s12955-025-02357-z
DO - 10.1186/s12955-025-02357-z
M3 - Review
C2 - 40188134
AN - SCOPUS:105003169234
SN - 1477-7525
VL - 23
JO - Health and Quality of Life Outcomes
JF - Health and Quality of Life Outcomes
IS - 1
M1 - 31
ER -