Abstract
Protein-tyrosine phosphatase SHP-1 is the key neg. regulator of numerous signaling pathways. SHP-1 is expressed in the hematopietic and epithelial cells as two structurally similar mRNA transcripts controlled by two different promoters designated P2 and P1, resp. Whereas the transcriptional regulation of the SHP-1 gene P1 promoter has been partially elucidated, the structure and functional control of the P2 promoter remain unknown despite the crit. role played by SHP-1 in the normal and malignant lymphoid and other hematopoetic cells. Using luciferase reporter assays with the set of constructs that contained a gradually truncated intron 1 of the SHP-1 gene, we identified the minimal (
Originalsprog | Engelsk |
---|---|
Tidsskrift | Journal of Biological Chemistry |
Vol/bind | 282 |
Udgave nummer | 9 |
Sider (fra-til) | 6316-6323 |
Antal sider | 8 |
ISSN | 0021-9258 |
DOI | |
Status | Udgivet - 2007 |
Udgivet eksternt | Ja |
Bibliografisk note
M1 - Copyright (C) 2018 American Chemical Society (ACS). All Rights Reserved.CAPLUS AN 2007:204113(Journal)