PU.1 activates transcription of SHP-1 gene in hematopoietic cells.

Pawel Wlodarski, Qian Zhang, Xiaobin Liu, Monika Kasprzycka, Michal Marzec, Mariusz A. Wasik

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

27 Citationer (Scopus)

Abstract

Protein-tyrosine phosphatase SHP-1 is the key neg. regulator of numerous signaling pathways. SHP-1 is expressed in the hematopietic and epithelial cells as two structurally similar mRNA transcripts controlled by two different promoters designated P2 and P1, resp. Whereas the transcriptional regulation of the SHP-1 gene P1 promoter has been partially elucidated, the structure and functional control of the P2 promoter remain unknown despite the crit. role played by SHP-1 in the normal and malignant lymphoid and other hematopoetic cells. Using luciferase reporter assays with the set of constructs that contained a gradually truncated intron 1 of the SHP-1 gene, we identified the minimal (
OriginalsprogEngelsk
TidsskriftJournal of Biological Chemistry
Vol/bind282
Udgave nummer9
Sider (fra-til)6316-6323
Antal sider8
ISSN0021-9258
DOI
StatusUdgivet - 2007
Udgivet eksterntJa

Bibliografisk note

M1 - Copyright (C) 2018 American Chemical Society (ACS). All Rights Reserved.

CAPLUS AN 2007:204113(Journal)

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