Pulmonary delivery systems for antimicrobial peptides

Lucrezia Caselli, Gisele R. Rodrigues, Octavio L. Franco, Martin Malmsten*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftReviewForskningpeer review

1 Citationer (Scopus)

Abstract

Bacterial infections of the respiratory tract cause millions of deaths annually. Several diseases exist wherein (1) bacterial infection is the main cause of disease (e.g., tuberculosis and bacterial pneumonia), (2) bacterial infection is a consequence of disease and worsens the disease prognosis (e.g., cystic fibrosis), and (3) bacteria-triggered inflammation propagates the disease (e.g., chronic obstructive pulmonary disease). Current approaches to combat infections generally include long and aggressive antibiotic treatments, which challenge patient compliance, thereby making relapses common and contributing to the development of antibiotic resistance. Consequently, the proportion of infections that cannot be treated with conventional antibiotics is rapidly increasing, and novel therapies are urgently needed. In this context, antimicrobial peptides (AMPs) have received considerable attention as they may exhibit potent antimicrobial effects against antibiotic-resistant bacterial strains but with modest toxicity. In addition, some AMPs suppress inflammation and provide other host defense functions (motivating the alternative term host defense peptides (HDPs)). However, the delivery of AMPs is complicated because they are large, positively charged, and amphiphilic. As a result of this, AMP delivery systems have recently attracted attention. For airway infections, the currently investigated delivery approaches range from aerosols and dry powders to various self-assembly and nanoparticle carrier systems, as well as their combinations. In this paper, we discuss recent developments in the field, ranging from mechanistic mode-of-action studies to the application of these systems for combating bacterial infections in the airways.

OriginalsprogEngelsk
TidsskriftCritical Reviews in Biotechnology
Vol/bind44
Udgave nummer6
Sider (fra-til)963-980
ISSN0738-8551
DOI
StatusUdgivet - 2024

Bibliografisk note

Funding Information:
This work was funded by the Swedish Research Council (Grant Number 2021-06053; MM, LC) and the National Council for Scientific and Technological Development (CNPq, CAPES, FAPDF, FUNDECT, GRR, and OLF).

Publisher Copyright:
© 2023 Informa UK Limited, trading as Taylor & Francis Group.

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