Purinergic receptors in the endocrine and exocrine pancreas.

I Novak

doi:10.1007/s11302-007-9087-6

Purinergic receptors in the endocrine and exocrine pancreas.

I Novak

Molecular Integrative Physiology

Publikation: Bidrag til tidsskrift › Review › Forskning

85 Citationer (Scopus)

Abstract

Udgivelsesdato: 2007-Dec-11

Originalsprog	Engelsk
Tidsskrift	Purinergic Signalling
Vol/bind	4
Sider (fra-til)	237-253
Antal sider	17
ISSN	1573-9538
DOI	https://doi.org/10.1007/s11302-007-9087-6
Status	Udgivet - 2008

Bibliografisk note

Keywords Adenosine receptors - ATP release - Beta cell - BK channels - Cystic fibrosis - CFTR - Diabetes - Glucagon - IK channels - Pancreatitis

Adgang til dokumentet

10.1007/s11302-007-9087-6

Citationsformater

@article{248d46a0179411ddbee902004c4f4f50,

title = "Purinergic receptors in the endocrine and exocrine pancreas.",

abstract = "The pancreas is a complex gland performing both endocrine and exocrine functions. In recent years there has been increasing evidence that both endocrine and exocrine cells possess purinergic receptors, which influence processes such as insulin secretion and epithelial ion transport. Most commonly, these processes have been viewed separately. In beta cells, stimulation of P2Y(1) receptors amplifies secretion of insulin in the presence of glucose. Nucleotides released from secretory granules could also contribute to autocrine/paracrine regulation in pancreatic islets. In addition to P2Y(1) receptors, there is also evidence for other P2 and adenosine receptors in beta cells (P2Y(2), P2Y(4), P2Y(6), P2X subtypes and A(1) receptors) and in glucagon-secreting alpha cells (P2X(7), A(2) receptors). In the exocrine pancreas, acini release ATP and ATP-hydrolysing and ATP-generating enzymes. P2 receptors are prominent in pancreatic ducts, and several studies indicate that P2Y(2), P2Y(4), P2Y(11), P2X(4) and P2X(7) receptors could regulate secretion, primarily by affecting Cl(-) and K(+) channels and intracellular Ca(2+) signalling. In order to understand the physiology of the whole organ, it is necessary to consider the full complement of purinergic receptors on different cells as well as the structural and functional relation between various cells within the whole organ. In addition to the possible physiological function of purinergic receptors, this review analyses whether the receptors could be potential therapeutic targets for drug design aimed at treatment of pancreatic diseases.",

author = "I Novak",

note = "Keywords Adenosine receptors - ATP release - Beta cell - BK channels - Cystic fibrosis - CFTR - Diabetes - Glucagon - IK channels - Pancreatitis",

year = "2008",

doi = "10.1007/s11302-007-9087-6",

language = "English",

volume = "4",

pages = "237--253",

journal = "Purinergic Signalling",

issn = "1573-9538",

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T1 - Purinergic receptors in the endocrine and exocrine pancreas.

AU - Novak, I

N1 - Keywords Adenosine receptors - ATP release - Beta cell - BK channels - Cystic fibrosis - CFTR - Diabetes - Glucagon - IK channels - Pancreatitis

PY - 2008

Y1 - 2008

N2 - The pancreas is a complex gland performing both endocrine and exocrine functions. In recent years there has been increasing evidence that both endocrine and exocrine cells possess purinergic receptors, which influence processes such as insulin secretion and epithelial ion transport. Most commonly, these processes have been viewed separately. In beta cells, stimulation of P2Y(1) receptors amplifies secretion of insulin in the presence of glucose. Nucleotides released from secretory granules could also contribute to autocrine/paracrine regulation in pancreatic islets. In addition to P2Y(1) receptors, there is also evidence for other P2 and adenosine receptors in beta cells (P2Y(2), P2Y(4), P2Y(6), P2X subtypes and A(1) receptors) and in glucagon-secreting alpha cells (P2X(7), A(2) receptors). In the exocrine pancreas, acini release ATP and ATP-hydrolysing and ATP-generating enzymes. P2 receptors are prominent in pancreatic ducts, and several studies indicate that P2Y(2), P2Y(4), P2Y(11), P2X(4) and P2X(7) receptors could regulate secretion, primarily by affecting Cl(-) and K(+) channels and intracellular Ca(2+) signalling. In order to understand the physiology of the whole organ, it is necessary to consider the full complement of purinergic receptors on different cells as well as the structural and functional relation between various cells within the whole organ. In addition to the possible physiological function of purinergic receptors, this review analyses whether the receptors could be potential therapeutic targets for drug design aimed at treatment of pancreatic diseases.

AB - The pancreas is a complex gland performing both endocrine and exocrine functions. In recent years there has been increasing evidence that both endocrine and exocrine cells possess purinergic receptors, which influence processes such as insulin secretion and epithelial ion transport. Most commonly, these processes have been viewed separately. In beta cells, stimulation of P2Y(1) receptors amplifies secretion of insulin in the presence of glucose. Nucleotides released from secretory granules could also contribute to autocrine/paracrine regulation in pancreatic islets. In addition to P2Y(1) receptors, there is also evidence for other P2 and adenosine receptors in beta cells (P2Y(2), P2Y(4), P2Y(6), P2X subtypes and A(1) receptors) and in glucagon-secreting alpha cells (P2X(7), A(2) receptors). In the exocrine pancreas, acini release ATP and ATP-hydrolysing and ATP-generating enzymes. P2 receptors are prominent in pancreatic ducts, and several studies indicate that P2Y(2), P2Y(4), P2Y(11), P2X(4) and P2X(7) receptors could regulate secretion, primarily by affecting Cl(-) and K(+) channels and intracellular Ca(2+) signalling. In order to understand the physiology of the whole organ, it is necessary to consider the full complement of purinergic receptors on different cells as well as the structural and functional relation between various cells within the whole organ. In addition to the possible physiological function of purinergic receptors, this review analyses whether the receptors could be potential therapeutic targets for drug design aimed at treatment of pancreatic diseases.

U2 - 10.1007/s11302-007-9087-6

DO - 10.1007/s11302-007-9087-6

M3 - Review

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JO - Purinergic Signalling

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SN - 1573-9538

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