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Putting the spotlight on donation-related risks and donor safety - are we succeeding in protecting donors?

  • Christina Mikkelsen*
  • , Gaia Mori
  • , Suzanna M. van Walraven
  • , Johanna Castren
  • , Sharon Zahra
  • , Sheila MacLennan
  • , Kirsten Seidel
  • , Stefano Fontana
  • , Eva Veropalumbo
  • , Livia Cannata
  • , Simonetta Pupella
  • , Maria Kvist
  • , Marjan Happel
  • , Piia Korkalainen
  • , Birgit Wulff
  • , Jesus Fernandez-Sojo
  • , Cristina Eguizabal
  • , Fernando Urbano
  • , Miguel Angel Vesga
  • , Primoz Pozenel
    • Marian van Kraaij, Morten Bagge Hansen, Ed Slot, Henrik Ullum
*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Background and objective The European consortium project TRANSPOSE (TRANSfusion and transplantation: PrOtection and SElection of donors) aimed to assess and evaluate the risks to donors of Substances of Human Origin (SoHO), and to identify gaps between current donor vigilance systems and perceived risks.

Materials and methods National and local data from participating organizations on serious and non-serious adverse reactions in donors were collected from 2014 to 2017. Following this, a survey was performed among participants to identify risks not included in the data sets. Finally, participants rated the risks according to severity, level of evidence and prevalence.

Results Significant discrepancies between anticipated donor risks and the collected data were found. Furthermore, many participants reported that national data on adverse reactions in donors of stem cells, gametes, embryos and tissues were not routinely collected and/or available.

Conclusions These findings indicate that there is a need to further develop and standardize donor vigilance in Europe and to include long-term risks to donors, which are currently underreported, ensuring donor health and securing the future supply of SoHO.

OriginalsprogEngelsk
TidsskriftVox Sanguinis
Vol/bind116
Udgave nummer3
Sider (fra-til)313-323
ISSN0042-9007
DOI
StatusUdgivet - 2021

Finansiering

This paper is part of the project '738145/TRANSPOSE' which has received funding from the European Union's Health Programme (2014-2020). The content of this paper represents the views of the authors only and is their sole responsibility; it cannot be considered to reflect the views of the European Commission and/or the Consumers, Health, Agriculture and Food Executive Agency or any other body of the European Union. The European Commission and the Agency do not accept any responsibility for use that may be made of the information it contains.

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