Quantitative computed tomography: emphysema and airway wall thickness by sex, age and smoking

T B Grydeland; A Dirksen; H O Coxson; S G Pillai; S Sharma; G E Eide; A Gulsvik; P S Bakke

doi:10.1183/09031936.00167908

Quantitative computed tomography: emphysema and airway wall thickness by sex, age and smoking

T B Grydeland, A Dirksen, H O Coxson, S G Pillai, S Sharma, G E Eide, A Gulsvik, P S Bakke

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › peer review

159 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-Oct

Originalsprog	Engelsk
Tidsskrift	European Respiratory Journal
Vol/bind	34
Udgave nummer	4
Sider (fra-til)	858-65
Antal sider	8
ISSN	0903-1936
DOI	https://doi.org/10.1183/09031936.00167908
Status	Udgivet - 2009

Bibliografisk note

Keywords: Age Factors; Aged; Emphysema; Female; Humans; Lung; Male; Middle Aged; Norway; Prevalence; Smoking; Spirometry; Tomography, X-Ray Computed

Adgang til dokumentet

10.1183/09031936.00167908

Citationsformater

@article{2ed8a120791411df928f000ea68e967b,

title = "Quantitative computed tomography: emphysema and airway wall thickness by sex, age and smoking",

abstract = "We investigated how quantitative high-resolution computed tomography (HRCT) measures of emphysema and airway wall thickness (AWT) vary with sex, age and smoking history. We included 463 chronic obstructive pulmonary disease (COPD) cases and 431 controls. All included subjects were current or ex-smokers aged > or = 40 yrs, and all underwent spirometry and HRCT examination. The HRCT images were quantitatively assessed, providing indices on lung density and airway dimensions. The median (25-75th percentile) %LAA950 (% low-attenuation area < -950 HU) was 8.9 (3-19) and 4.7 (1-16) in male and female COPD cases, respectively, and 0.71 (0.3-1.6) and 0.32 (0.1-0.8) in male and female controls, respectively. %LAA950 was higher in ex-smokers and increased with increasing age and with increasing number of pack-years. The mean+/-SD standardised AWT was 0.504+/-0.030 and 0.474+/-0.031 in male and female COPD cases, respectively, and 0.488+/-0.028 and 0.463+/-0.025 in male and female controls, respectively. AWT decreased with increasing age in cases, and increased with the degree of current smoking in all subjects. We found significant differences in quantitative HRCT measures of emphysema and AWT between varying sex, age and smoking groups of both control and COPD subjects.",

author = "Grydeland, {T B} and A Dirksen and Coxson, {H O} and Pillai, {S G} and S Sharma and Eide, {G E} and A Gulsvik and Bakke, {P S}",

note = "Keywords: Age Factors; Aged; Emphysema; Female; Humans; Lung; Male; Middle Aged; Norway; Prevalence; Smoking; Spirometry; Tomography, X-Ray Computed",

year = "2009",

doi = "10.1183/09031936.00167908",

language = "English",

volume = "34",

pages = "858--65",

journal = "The European Respiratory Journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "4",

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TY - JOUR

T1 - Quantitative computed tomography: emphysema and airway wall thickness by sex, age and smoking

AU - Grydeland, T B

AU - Dirksen, A

AU - Coxson, H O

AU - Pillai, S G

AU - Sharma, S

AU - Eide, G E

AU - Gulsvik, A

AU - Bakke, P S

N1 - Keywords: Age Factors; Aged; Emphysema; Female; Humans; Lung; Male; Middle Aged; Norway; Prevalence; Smoking; Spirometry; Tomography, X-Ray Computed

PY - 2009

Y1 - 2009

N2 - We investigated how quantitative high-resolution computed tomography (HRCT) measures of emphysema and airway wall thickness (AWT) vary with sex, age and smoking history. We included 463 chronic obstructive pulmonary disease (COPD) cases and 431 controls. All included subjects were current or ex-smokers aged > or = 40 yrs, and all underwent spirometry and HRCT examination. The HRCT images were quantitatively assessed, providing indices on lung density and airway dimensions. The median (25-75th percentile) %LAA950 (% low-attenuation area < -950 HU) was 8.9 (3-19) and 4.7 (1-16) in male and female COPD cases, respectively, and 0.71 (0.3-1.6) and 0.32 (0.1-0.8) in male and female controls, respectively. %LAA950 was higher in ex-smokers and increased with increasing age and with increasing number of pack-years. The mean+/-SD standardised AWT was 0.504+/-0.030 and 0.474+/-0.031 in male and female COPD cases, respectively, and 0.488+/-0.028 and 0.463+/-0.025 in male and female controls, respectively. AWT decreased with increasing age in cases, and increased with the degree of current smoking in all subjects. We found significant differences in quantitative HRCT measures of emphysema and AWT between varying sex, age and smoking groups of both control and COPD subjects.

AB - We investigated how quantitative high-resolution computed tomography (HRCT) measures of emphysema and airway wall thickness (AWT) vary with sex, age and smoking history. We included 463 chronic obstructive pulmonary disease (COPD) cases and 431 controls. All included subjects were current or ex-smokers aged > or = 40 yrs, and all underwent spirometry and HRCT examination. The HRCT images were quantitatively assessed, providing indices on lung density and airway dimensions. The median (25-75th percentile) %LAA950 (% low-attenuation area < -950 HU) was 8.9 (3-19) and 4.7 (1-16) in male and female COPD cases, respectively, and 0.71 (0.3-1.6) and 0.32 (0.1-0.8) in male and female controls, respectively. %LAA950 was higher in ex-smokers and increased with increasing age and with increasing number of pack-years. The mean+/-SD standardised AWT was 0.504+/-0.030 and 0.474+/-0.031 in male and female COPD cases, respectively, and 0.488+/-0.028 and 0.463+/-0.025 in male and female controls, respectively. AWT decreased with increasing age in cases, and increased with the degree of current smoking in all subjects. We found significant differences in quantitative HRCT measures of emphysema and AWT between varying sex, age and smoking groups of both control and COPD subjects.

U2 - 10.1183/09031936.00167908

DO - 10.1183/09031936.00167908

M3 - Journal article

C2 - 19324952

VL - 34

SP - 858

EP - 865

JO - The European Respiratory Journal

JF - The European Respiratory Journal

SN - 0903-1936

IS - 4

ER -