Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

Tim T Chiu; Thomas Elbenhardt Jensen; Lykke Sylow; Erik A. Richter; Amira Klip

doi:10.1016/j.cellsig.2011.05.022

Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

Tim T Chiu, Thomas Elbenhardt Jensen, Lykke Sylow, Erik A. Richter, Amira Klip

Publikation: Bidrag til tidsskrift › Review › peer review

124 Citationer (Scopus)

Abstract

Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle.

Originalsprog	Engelsk
Tidsskrift	Cellular Signalling
Vol/bind	23
Udgave nummer	10
Sider (fra-til)	1546-1554
Antal sider	9
ISSN	0898-6568
DOI	https://doi.org/10.1016/j.cellsig.2011.05.022
Status	Udgivet - 2011

Bibliografisk note

CURIS 2011 5200 065

Adgang til dokumentet

10.1016/j.cellsig.2011.05.022

Citationsformater

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AU - Chiu, Tim T

AU - Jensen, Thomas Elbenhardt

AU - Sylow, Lykke

AU - Richter, Erik A.

AU - Klip, Amira

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AB - Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle.

U2 - 10.1016/j.cellsig.2011.05.022

DO - 10.1016/j.cellsig.2011.05.022

M3 - Review

C2 - 21683139

SN - 0898-6568

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