Randomized, multi-center trial of two hypo-energetic diets in obese subjects: high- versus low-fat content

M Petersen, M A Taylor, W H M Saris, C Verdich, Søren Toubro, I Macdonald, S Rössner, V Stich, B Guy-Grand, D Langin, J A Martinez, O Pedersen, C Holst, Thorkild I.A. Sørensen, Arne Astrup

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72 Citationer (Scopus)

Abstract

OBJECTIVE: To investigate whether a hypo-energetic low-fat diet is superior to a hypo-energetic high-fat diet for the treatment of obesity. DESIGN: Open-label, 10-week dietary intervention comparing two hypo-energetic (-600 kcal/day) diets with a fat energy percent of 20-25 or 40-45.Subjects:Obese (BMI >or=30 kg/m(2)) adult subjects (n = 771), from eight European centers. MEASUREMENTS: Body weight loss, dropout rates, proportion of subjects who lost more than 10% of initial body weight, blood lipid profile, insulin and glucose. RESULTS: The dietary fat energy percent was 25% in the low-fat group and 40% in the high-fat group (mean difference: 16 (95% confidence interval (CI) 15-17)%). Average weight loss was 6.9 kg in the low-fat group and 6.6 kg in the high-fat group (mean difference: 0.3 (95% CI -0.2 to 0.8) kg). Dropout was 13.6% (n = 53) in the low-fat group and 18.3% (n = 70) in the high-fat group (P=0.001). Among completers, more subjects lost >10% in the low-fat group than in the high-fat group ((20.8%, n = 70) versus (14.7%, n = 46), P = 0.02). Fasting plasma total, low-density lipoprotein- and high-density lipoprotein-cholesterol decreased in both groups, but more so in the low-fat group than in the high-fat group. Fasting plasma insulin and glucose were lowered equally by both diets. CONCLUSIONS: The low-fat diet produced similar mean weight loss as the high-fat diet, but resulted in more subjects losing >10% of initial body weight and fewer dropouts. Both diets produced favorable changes in fasting blood lipids, insulin and glucose.
OriginalsprogEngelsk
TidsskriftInternational Journal of Obesity
Vol/bind30
Udgave nummer3
Sider (fra-til)552-560
Antal sider9
ISSN0307-0565
DOI
StatusUdgivet - 2006

Bibliografisk note

Keywords: Adult; Anthropometry; Blood Glucose; Body Composition; Body Weight; Diet, Fat-Restricted; Diet, Reducing; Dietary Fats; Female; Humans; Insulin; Lipids; Male; Middle Aged; Obesity; Patient Dropouts; Treatment Outcome; Weight Loss

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