Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Infection and Immunity |
| Vol/bind | 73 |
| Udgave nummer | 5 |
| Sider (fra-til) | 2841-7 |
| Antal sider | 6 |
| ISSN | 0019-9567 |
| DOI | |
| Status | Udgivet - 2005 |
Bibliografisk note
Keywords: Animals; Antibodies, Protozoan; Antigenic Variation; Antigens, Protozoan; Chondroitin Sulfates; Erythrocytes; Female; Ghana; Humans; Immunoglobulin G; Lactation; Malaria, Falciparum; Male; Placenta; Placenta Diseases; Plasmodium falciparum; Pregnancy; Pregnancy Complications, Parasitic; Time FactorsAdgang til dokumentet
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Rapid acquisition of isolate-specific antibodies to chondroitin sulfate A-adherent Plasmodium falciparum isolates in Ghanaian primigravidae. / Cox, Sharon E; Staalsoe, Trine; Arthur, Paul; Bulmer, Judith N; Hviid, Lars; Yeboah-Antwi, Kojo; Kirkwood, Betty R; Riley, Eleanor M.
I: Infection and Immunity, Bind 73, Nr. 5, 2005, s. 2841-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Rapid acquisition of isolate-specific antibodies to chondroitin sulfate A-adherent Plasmodium falciparum isolates in Ghanaian primigravidae
AU - Cox, Sharon E
AU - Staalsoe, Trine
AU - Arthur, Paul
AU - Bulmer, Judith N
AU - Hviid, Lars
AU - Yeboah-Antwi, Kojo
AU - Kirkwood, Betty R
AU - Riley, Eleanor M
N1 - Keywords: Animals; Antibodies, Protozoan; Antigenic Variation; Antigens, Protozoan; Chondroitin Sulfates; Erythrocytes; Female; Ghana; Humans; Immunoglobulin G; Lactation; Malaria, Falciparum; Male; Placenta; Placenta Diseases; Plasmodium falciparum; Pregnancy; Pregnancy Complications, Parasitic; Time Factors
PY - 2005
Y1 - 2005
N2 - Recent evidence suggests that pregnancy-associated malaria (PAM), associated with maternal anemia and low birth weight, results from preferential sequestration of parasitized red blood cells (pRBC) in the placenta via binding of variant surface antigens (VSA) expressed on the surface of pRBC to chondroitin sulfate A (CSA). The VSA mediating CSA binding (VSA(CSA)) and thus sequestration of pRBC in the placenta are antigenically distinct from those that mediate pRBC sequestration elsewhere in the body, and it has been suggested that VSA(CSA) are relatively conserved and may thus constitute an attractive target for vaccination against PAM. Using flow cytometry, levels of antibody to VSA and VSA(CSA) expressed on the surface of red blood cells infected with Plasmodium falciparum isolates were measured during pregnancy and lactation in Ghanaian primigravid women enrolled in a trial of maternal vitamin A supplementation. Antibody responses to VSA(CSA) were detected within the first trimester of pregnancy and increased with increasing duration of pregnancy, and they seemed to be isolate specific, indicating that different CSA-adherent parasite lines express antigenically distinct VSA and thus may not be as antigenically conserved as has been previously suggested. Levels of anti-VSA(CSA) were not significantly associated with placental malarial infection determined by histology, indicating that primary immune responses to VSA(CSA) may not be sufficient to eradicate placental parasitemia in primigravidae.
AB - Recent evidence suggests that pregnancy-associated malaria (PAM), associated with maternal anemia and low birth weight, results from preferential sequestration of parasitized red blood cells (pRBC) in the placenta via binding of variant surface antigens (VSA) expressed on the surface of pRBC to chondroitin sulfate A (CSA). The VSA mediating CSA binding (VSA(CSA)) and thus sequestration of pRBC in the placenta are antigenically distinct from those that mediate pRBC sequestration elsewhere in the body, and it has been suggested that VSA(CSA) are relatively conserved and may thus constitute an attractive target for vaccination against PAM. Using flow cytometry, levels of antibody to VSA and VSA(CSA) expressed on the surface of red blood cells infected with Plasmodium falciparum isolates were measured during pregnancy and lactation in Ghanaian primigravid women enrolled in a trial of maternal vitamin A supplementation. Antibody responses to VSA(CSA) were detected within the first trimester of pregnancy and increased with increasing duration of pregnancy, and they seemed to be isolate specific, indicating that different CSA-adherent parasite lines express antigenically distinct VSA and thus may not be as antigenically conserved as has been previously suggested. Levels of anti-VSA(CSA) were not significantly associated with placental malarial infection determined by histology, indicating that primary immune responses to VSA(CSA) may not be sufficient to eradicate placental parasitemia in primigravidae.
U2 - 10.1128/IAI.73.5.2841-2847.2005
DO - 10.1128/IAI.73.5.2841-2847.2005
M3 - Journal article
C2 - 15845489
VL - 73
SP - 2841
EP - 2847
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 5
ER -