Rapidly boosted Plasma IL-5 induced by treatment of human Schistosomiasis haematobium is dependent on antigen dose, IgE and eosinophils

Shona Wilson; Frances M. Jones; Hassan K. M. Fofana; Aissata Doucouré; Aly Landouré; Gachuhi Kimani; Joseph K. Mwatha; Moussa Sacko; Birgitte J Vennervald; David W Dunne

doi:10.1371/journal.pntd.0002149

Rapidly boosted Plasma IL-5 induced by treatment of human Schistosomiasis haematobium is dependent on antigen dose, IgE and eosinophils

Shona Wilson, Frances M. Jones, Hassan K. M. Fofana, Aissata Doucouré, Aly Landouré, Gachuhi Kimani, Joseph K. Mwatha, Moussa Sacko, Birgitte J Vennervald, David W Dunne

Sektion, Parasitology and Aquatic Pathobiology

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

15 Citationer (Scopus)

Abstract

IgE specific to worm antigen (SWA) and pre-treatment eosinophil number, are associated with human immunity to re-infection with schistosomes after chemotherapeutic treatment. Treatment significantly elevates circulating IL-5 24-hr post-treatment of Schistosoma mansoni. Here we investigate if praziquantel treatment of human schistosomiasis haematobium also boosts circulating IL-5, the immunological and parasitological factors that predispose to this, and the relationship between these and subsequent immunity to post-treatment re-infection.

Originalsprog	Engelsk
Artikelnummer	e2149
Tidsskrift	P L o S Neglected Tropical Diseases (Online)
Vol/bind	7
Udgave nummer	3
Antal sider	8
ISSN	1935-2735
DOI	https://doi.org/10.1371/journal.pntd.0002149
Status	Udgivet - 2013

Adgang til dokumentet

10.1371/journal.pntd.0002149

Citationsformater

Wilson, S., Jones, F. M., Fofana, H. K. M., Doucouré, A., Landouré, A., Kimani, G., Mwatha, J. K., Sacko, M., Vennervald, B. J., & Dunne, D. W. (2013). Rapidly boosted Plasma IL-5 induced by treatment of human Schistosomiasis haematobium is dependent on antigen dose, IgE and eosinophils. P L o S Neglected Tropical Diseases (Online), 7(3), [e2149]. https://doi.org/10.1371/journal.pntd.0002149

Rapidly boosted Plasma IL-5 induced by treatment of human Schistosomiasis haematobium is dependent on antigen dose, IgE and eosinophils. / Wilson, Shona; Jones, Frances M.; Fofana, Hassan K. M.; Doucouré, Aissata; Landouré, Aly; Kimani, Gachuhi; Mwatha, Joseph K.; Sacko, Moussa; Vennervald, Birgitte J; Dunne, David W.

I: P L o S Neglected Tropical Diseases (Online), Bind 7, Nr. 3, e2149, 2013.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Wilson, S, Jones, FM, Fofana, HKM, Doucouré, A, Landouré, A, Kimani, G, Mwatha, JK, Sacko, M, Vennervald, BJ & Dunne, DW 2013, 'Rapidly boosted Plasma IL-5 induced by treatment of human Schistosomiasis haematobium is dependent on antigen dose, IgE and eosinophils', P L o S Neglected Tropical Diseases (Online), bind 7, nr. 3, e2149. https://doi.org/10.1371/journal.pntd.0002149

Wilson, Shona ; Jones, Frances M. ; Fofana, Hassan K. M. ; Doucouré, Aissata ; Landouré, Aly ; Kimani, Gachuhi ; Mwatha, Joseph K. ; Sacko, Moussa ; Vennervald, Birgitte J ; Dunne, David W. / Rapidly boosted Plasma IL-5 induced by treatment of human Schistosomiasis haematobium is dependent on antigen dose, IgE and eosinophils. I: P L o S Neglected Tropical Diseases (Online). 2013 ; Bind 7, Nr. 3.

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title = "Rapidly boosted Plasma IL-5 induced by treatment of human Schistosomiasis haematobium is dependent on antigen dose, IgE and eosinophils",

abstract = "IgE specific to worm antigen (SWA) and pre-treatment eosinophil number, are associated with human immunity to re-infection with schistosomes after chemotherapeutic treatment. Treatment significantly elevates circulating IL-5 24-hr post-treatment of Schistosoma mansoni. Here we investigate if praziquantel treatment of human schistosomiasis haematobium also boosts circulating IL-5, the immunological and parasitological factors that predispose to this, and the relationship between these and subsequent immunity to post-treatment re-infection.",

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T1 - Rapidly boosted Plasma IL-5 induced by treatment of human Schistosomiasis haematobium is dependent on antigen dose, IgE and eosinophils

AU - Wilson, Shona

AU - Jones, Frances M.

AU - Fofana, Hassan K. M.

AU - Doucouré, Aissata

AU - Landouré, Aly

AU - Kimani, Gachuhi

AU - Mwatha, Joseph K.

AU - Sacko, Moussa

AU - Vennervald, Birgitte J

AU - Dunne, David W

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N2 - IgE specific to worm antigen (SWA) and pre-treatment eosinophil number, are associated with human immunity to re-infection with schistosomes after chemotherapeutic treatment. Treatment significantly elevates circulating IL-5 24-hr post-treatment of Schistosoma mansoni. Here we investigate if praziquantel treatment of human schistosomiasis haematobium also boosts circulating IL-5, the immunological and parasitological factors that predispose to this, and the relationship between these and subsequent immunity to post-treatment re-infection.

AB - IgE specific to worm antigen (SWA) and pre-treatment eosinophil number, are associated with human immunity to re-infection with schistosomes after chemotherapeutic treatment. Treatment significantly elevates circulating IL-5 24-hr post-treatment of Schistosoma mansoni. Here we investigate if praziquantel treatment of human schistosomiasis haematobium also boosts circulating IL-5, the immunological and parasitological factors that predispose to this, and the relationship between these and subsequent immunity to post-treatment re-infection.

KW - Adolescent

KW - Adult

KW - Animals

KW - Anthelmintics

KW - Antigens, Helminth

KW - Child

KW - Child, Preschool

KW - Eosinophils

KW - Female

KW - Humans

KW - Immunoglobulin E

KW - Interleukin-5

KW - Male

KW - Plasma

KW - Praziquantel

KW - Schistosoma haematobium

KW - Schistosomiasis haematobia

KW - Young Adult

U2 - 10.1371/journal.pntd.0002149

DO - 10.1371/journal.pntd.0002149

M3 - Journal article

C2 - 23556029

VL - 7

JO - P L o S Neglected Tropical Diseases (Online)

JF - P L o S Neglected Tropical Diseases (Online)

SN - 1935-2735

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