Reactivation of tuberculosis during immunosuppressive treatment in a patient with a positive QuantiFERON-RD1 test

Bidragets oversatte titel: Reactivation of tuberculosis during immunosuppressive treatment in a patient with a positive QuantiFERON-RD1 test.

Pernille Ravn, Martin E Munk, Ase Bengaard Andersen, Bettina Lundgren, Lars N Nielsen, Troels Lillebaek, Inge J Soerensen, Peter Andersen, Karin Weldingh

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    Abstract

    A patient with polymyositis developed tuberculosis during immunosuppressive treatment. Tuberculin Skin Test and chest X-ray failed to demonstrate latent tuberculosis, whereas a blood sample that was tested with a modified QuantiFERON-TB-assay, using the recombinant ESAT-6 and CFP-10, was positive indicating that this patient was latently infected before immunosuppressive therapy. This case indicates the risk of progressing from latent to active tuberculosis given that the subject is RD1 responsive, and we believe that preventive anti-tuberculous treatment could have prevented this case of tuberculosis. We suggest that RD1 based tests are evaluated further in immunocompromised patients.
    Bidragets oversatte titelReactivation of tuberculosis during immunosuppressive treatment in a patient with a positive QuantiFERON-RD1 test.
    OriginalsprogEngelsk
    TidsskriftScandinavian Journal of Infectious Diseases
    Vol/bind36
    Udgave nummer6-7
    Sider (fra-til)499-501
    Antal sider3
    ISSN0036-5548
    StatusUdgivet - 2004

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