@article{1c3350dde9064aaea9faa035f9d5a2d0,
title = "Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an NS5A inhibitor but not interferon-a",
abstract = "Heterogeneity in the hepatitis C virus (HCV) protein NS5A influences its sensitivity to interferon-based therapy. Furthermore, NS5A is an important target for development of HCV-specific inhibitors. We aimed to develop recombinant infectious cell culture systems that express NS5A from isolates of the 7 major HCV genotypes, and determining their sensitivity to a specific NS5A inhibitor and to interferon-a.",
keywords = "Antiviral Agents, Cell Line, Tumor, Cell Survival, Dose-Response Relationship, Drug, Enzyme Inhibitors, Genotype, Hepacivirus, High-Throughput Screening Assays, Humans, Imidazoles, Interferon-alpha, Mutation, Phenotype, Recombinant Proteins, Time Factors, Viral Nonstructural Proteins, Virus Replication",
author = "Scheel, {Troels K H} and Gottwein, {Judith M} and Mikkelsen, {Lotte S} and Jensen, {Tanja B} and Jens Bukh",
note = "Copyright {\textcopyright} 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.",
year = "2011",
doi = "10.1053/j.gastro.2010.11.036",
language = "English",
volume = "140",
pages = "1032--42",
journal = "Gastroenterology Today",
issn = "0969-0131",
publisher = "Media Publishing Company",
number = "3",
}