Recovery of Cardiac Function Following COVID-19 - ECHOVID-19: A Prospective Longitudinal Cohort Study

Mats Christian Højbjerg Lassen; Kristoffer Grundtvig Skaarup; Jannie Nørgaard Lind; Alia Saed Alhakak; Morten Sengeløv; Anne Bjerg Nielsen; Jakob Øystein Simonsen; Niklas Dyrby Johansen; Filip Søskov Davidovski; Jacob Christensen; Henning Bundgaard; Christian Hassager; Reza Jabbari; Jørn Carlsen; Ole Kirk; Matias Greve Lindholm; Ole Peter Kristiansen; Olav Wendelboe Nielsen; Charlotte Suppli Ulrik; Pradeesh Sivapalan; Gunnar Gislason; Rasmus Møgelvang; Gorm Boje Jensen; Peter Schnohr; Peter Søgaard; Scott D. Solomon; Kasper Iversen; Jens Ulrik Stæhr Jensen; Morten Schou; Tor Biering-Sørensen

doi:10.1002/ejhf.2347

Recovery of Cardiac Function Following COVID-19 - ECHOVID-19: A Prospective Longitudinal Cohort Study

Mats Christian Højbjerg Lassen, Kristoffer Grundtvig Skaarup, Jannie Nørgaard Lind, Alia Saed Alhakak, Morten Sengeløv, Anne Bjerg Nielsen, Jakob Øystein Simonsen, Niklas Dyrby Johansen, Filip Søskov Davidovski, Jacob Christensen, Henning Bundgaard, Christian Hassager, Reza Jabbari, Jørn Carlsen, Ole Kirk, Matias Greve Lindholm, Ole Peter Kristiansen, Olav Wendelboe Nielsen, Charlotte Suppli Ulrik, Pradeesh SivapalanGunnar Gislason, Rasmus Møgelvang, Gorm Boje Jensen, Peter Schnohr, Peter Søgaard, Scott D. Solomon, Kasper Iversen, Jens Ulrik Stæhr Jensen, Morten Schou, Tor Biering-Sørensen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Aims
The degree of cardiovascular sequelae following COVID-19 remains unknown. The aim of this study was to investigate whether cardiac function recovers following COVID-19.

Methods and results
A consecutive sample of patients hospitalized with COVID-19 was prospectively included in this longitudinal study. All patients underwent an echocardiographic examination during hospitalization and 2 months later. All participants were successfully matched 1:1 with COVID-19-free controls by age and sex. A total of 91 patients were included (mean age 63 ± 12 years, 59% male). A median of 77 days (interquartile range: 72–92) passed between the two examinations. Right ventricular (RV) function improved following resolution of COVID-19: tricuspid annular plane systolic excursion (TAPSE) (2.28 ± 0.40 cm vs. 2.11 ± 0.38 cm, P < 0.001) and RV longitudinal strain (RVLS) (25.3 ± 5.5% vs. 19.9 ± 5.8%, P < 0.001). In contrast, left ventricular (LV) systolic function assessed by global longitudinal strain (GLS) did not significantly improve (17.4 ± 2.9% vs. 17.6 ± 3.3%, P = 0.6). N-terminal pro-B-type natriuretic peptide decreased between the two examinations [177.6 (80.3–408.0) ng/L vs. 11.7 (5.7–24.0) ng/L, P < 0.001]. None of the participants had elevated troponins at follow-up compared to 18 (27.7%) during hospitalization. Recovered COVID-19 patients had significantly lower GLS (17.4 ± 2.9% vs. 18.8 ± 2.9%, P < 0.001 and adjusted P = 0.004), TAPSE (2.28 ± 0.40 cm vs. 2.67 ± 0.44 cm, P < 0.001 and adjusted P < 0.001), and RVLS (25.3 ± 5.5% vs. 26.6 ± 5.8%, P = 0.50 and adjusted P < 0.001) compared to matched controls.

Conclusion
Acute COVID-19 affected negatively RV function and cardiac biomarkers but recovered following resolution of COVID-19. In contrast, the observed reduced LV function during acute COVID-19 did not improve post-COVID-19. Compared to the matched controls, both LV and RV function remained impaired.

Originalsprog	Engelsk
Tidsskrift	European Journal of Heart Failure
Vol/bind	23
Udgave nummer	11
Sider (fra-til)	1903-1912
Antal sider	10
ISSN	1879-0844
DOI	https://doi.org/10.1002/ejhf.2347
Status	Udgivet - 2021

Emneord

COVID-19
follow-up
recovery following COVID-19
strain echocardiography

Adgang til dokumentet

10.1002/ejhf.2347

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652600/pdf/EJHF-23-1903.pdfLicens: Andet

Citationsformater

Lassen, M. C. H., Skaarup, K. G., Lind, J. N., Alhakak, A. S., Sengeløv, M., Nielsen, A. B., Simonsen, J. Ø., Johansen, N. D., Davidovski, F. S., Christensen, J., Bundgaard, H., Hassager, C., Jabbari, R., Carlsen, J., Kirk, O., Lindholm, M. G., Kristiansen, O. P., Nielsen, O. W., Ulrik, C. S., ... Biering-Sørensen, T. (2021). Recovery of Cardiac Function Following COVID-19 - ECHOVID-19: A Prospective Longitudinal Cohort Study. European Journal of Heart Failure, 23(11), 1903-1912. https://doi.org/10.1002/ejhf.2347

Recovery of Cardiac Function Following COVID-19 - ECHOVID-19 : A Prospective Longitudinal Cohort Study. / Lassen, Mats Christian Højbjerg; Skaarup, Kristoffer Grundtvig; Lind, Jannie Nørgaard; Alhakak, Alia Saed; Sengeløv, Morten; Nielsen, Anne Bjerg; Simonsen, Jakob Øystein; Johansen, Niklas Dyrby; Davidovski, Filip Søskov; Christensen, Jacob; Bundgaard, Henning ; Hassager, Christian; Jabbari, Reza; Carlsen, Jørn ; Kirk, Ole; Lindholm, Matias Greve; Kristiansen, Ole Peter; Nielsen, Olav Wendelboe ; Ulrik, Charlotte Suppli; Sivapalan, Pradeesh; Gislason, Gunnar; Møgelvang, Rasmus; Jensen, Gorm Boje; Schnohr, Peter; Søgaard, Peter; Solomon, Scott D.; Iversen, Kasper ; Jensen, Jens Ulrik Stæhr ; Schou, Morten ; Biering-Sørensen, Tor.

I: European Journal of Heart Failure, Bind 23, Nr. 11, 2021, s. 1903-1912.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Lassen, MCH, Skaarup, KG, Lind, JN, Alhakak, AS, Sengeløv, M, Nielsen, AB, Simonsen, JØ, Johansen, ND, Davidovski, FS, Christensen, J, Bundgaard, H , Hassager, C, Jabbari, R, Carlsen, J , Kirk, O, Lindholm, MG, Kristiansen, OP, Nielsen, OW , Ulrik, CS, Sivapalan, P, Gislason, G, Møgelvang, R, Jensen, GB, Schnohr, P, Søgaard, P, Solomon, SD, Iversen, K , Jensen, JUS , Schou, M & Biering-Sørensen, T 2021, 'Recovery of Cardiac Function Following COVID-19 - ECHOVID-19: A Prospective Longitudinal Cohort Study', European Journal of Heart Failure, bind 23, nr. 11, s. 1903-1912. https://doi.org/10.1002/ejhf.2347

Lassen, Mats Christian Højbjerg ; Skaarup, Kristoffer Grundtvig ; Lind, Jannie Nørgaard ; Alhakak, Alia Saed ; Sengeløv, Morten ; Nielsen, Anne Bjerg ; Simonsen, Jakob Øystein ; Johansen, Niklas Dyrby ; Davidovski, Filip Søskov ; Christensen, Jacob ; Bundgaard, Henning ; Hassager, Christian ; Jabbari, Reza ; Carlsen, Jørn ; Kirk, Ole ; Lindholm, Matias Greve ; Kristiansen, Ole Peter ; Nielsen, Olav Wendelboe ; Ulrik, Charlotte Suppli ; Sivapalan, Pradeesh ; Gislason, Gunnar ; Møgelvang, Rasmus ; Jensen, Gorm Boje ; Schnohr, Peter ; Søgaard, Peter ; Solomon, Scott D. ; Iversen, Kasper ; Jensen, Jens Ulrik Stæhr ; Schou, Morten ; Biering-Sørensen, Tor. / Recovery of Cardiac Function Following COVID-19 - ECHOVID-19 : A Prospective Longitudinal Cohort Study. I: European Journal of Heart Failure. 2021 ; Bind 23, Nr. 11. s. 1903-1912.

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title = "Recovery of Cardiac Function Following COVID-19 - ECHOVID-19: A Prospective Longitudinal Cohort Study",

abstract = "AimsThe degree of cardiovascular sequelae following COVID-19 remains unknown. The aim of this study was to investigate whether cardiac function recovers following COVID-19.Methods and resultsA consecutive sample of patients hospitalized with COVID-19 was prospectively included in this longitudinal study. All patients underwent an echocardiographic examination during hospitalization and 2 months later. All participants were successfully matched 1:1 with COVID-19-free controls by age and sex. A total of 91 patients were included (mean age 63 ± 12 years, 59% male). A median of 77 days (interquartile range: 72–92) passed between the two examinations. Right ventricular (RV) function improved following resolution of COVID-19: tricuspid annular plane systolic excursion (TAPSE) (2.28 ± 0.40 cm vs. 2.11 ± 0.38 cm, P < 0.001) and RV longitudinal strain (RVLS) (25.3 ± 5.5% vs. 19.9 ± 5.8%, P < 0.001). In contrast, left ventricular (LV) systolic function assessed by global longitudinal strain (GLS) did not significantly improve (17.4 ± 2.9% vs. 17.6 ± 3.3%, P = 0.6). N-terminal pro-B-type natriuretic peptide decreased between the two examinations [177.6 (80.3–408.0) ng/L vs. 11.7 (5.7–24.0) ng/L, P < 0.001]. None of the participants had elevated troponins at follow-up compared to 18 (27.7%) during hospitalization. Recovered COVID-19 patients had significantly lower GLS (17.4 ± 2.9% vs. 18.8 ± 2.9%, P < 0.001 and adjusted P = 0.004), TAPSE (2.28 ± 0.40 cm vs. 2.67 ± 0.44 cm, P < 0.001 and adjusted P < 0.001), and RVLS (25.3 ± 5.5% vs. 26.6 ± 5.8%, P = 0.50 and adjusted P < 0.001) compared to matched controls.ConclusionAcute COVID-19 affected negatively RV function and cardiac biomarkers but recovered following resolution of COVID-19. In contrast, the observed reduced LV function during acute COVID-19 did not improve post-COVID-19. Compared to the matched controls, both LV and RV function remained impaired.",

keywords = "COVID-19, follow-up, recovery following COVID-19, strain echocardiography, COVID-19, follow-up, recovery following COVID-19, strain echocardiography",

author = "Lassen, {Mats Christian H{\o}jbjerg} and Skaarup, {Kristoffer Grundtvig} and Lind, {Jannie N{\o}rgaard} and Alhakak, {Alia Saed} and Morten Sengel{\o}v and Nielsen, {Anne Bjerg} and Simonsen, {Jakob {\O}ystein} and Johansen, {Niklas Dyrby} and Davidovski, {Filip S{\o}skov} and Jacob Christensen and Henning Bundgaard and Christian Hassager and Reza Jabbari and J{\o}rn Carlsen and Ole Kirk and Lindholm, {Matias Greve} and Kristiansen, {Ole Peter} and Nielsen, {Olav Wendelboe} and Ulrik, {Charlotte Suppli} and Pradeesh Sivapalan and Gunnar Gislason and Rasmus M{\o}gelvang and Jensen, {Gorm Boje} and Peter Schnohr and Peter S{\o}gaard and Solomon, {Scott D.} and Kasper Iversen and Jensen, {Jens Ulrik St{\ae}hr} and Morten Schou and Tor Biering-S{\o}rensen",

year = "2021",

doi = "10.1002/ejhf.2347",

language = "English",

volume = "23",

pages = "1903--1912",

journal = "European Journal of Heart Failure",

issn = "1567-4215",

publisher = "JohnWiley & Sons Ltd",

number = "11",

}

TY - JOUR

T1 - Recovery of Cardiac Function Following COVID-19 - ECHOVID-19

T2 - A Prospective Longitudinal Cohort Study

AU - Lassen, Mats Christian Højbjerg

AU - Skaarup, Kristoffer Grundtvig

AU - Lind, Jannie Nørgaard

AU - Alhakak, Alia Saed

AU - Sengeløv, Morten

AU - Nielsen, Anne Bjerg

AU - Simonsen, Jakob Øystein

AU - Johansen, Niklas Dyrby

AU - Davidovski, Filip Søskov

AU - Christensen, Jacob

AU - Bundgaard, Henning

AU - Hassager, Christian

AU - Jabbari, Reza

AU - Carlsen, Jørn

AU - Kirk, Ole

AU - Lindholm, Matias Greve

AU - Kristiansen, Ole Peter

AU - Nielsen, Olav Wendelboe

AU - Ulrik, Charlotte Suppli

AU - Sivapalan, Pradeesh

AU - Gislason, Gunnar

AU - Møgelvang, Rasmus

AU - Jensen, Gorm Boje

AU - Schnohr, Peter

AU - Søgaard, Peter

AU - Solomon, Scott D.

AU - Iversen, Kasper

AU - Jensen, Jens Ulrik Stæhr

AU - Schou, Morten

AU - Biering-Sørensen, Tor

PY - 2021

Y1 - 2021

N2 - AimsThe degree of cardiovascular sequelae following COVID-19 remains unknown. The aim of this study was to investigate whether cardiac function recovers following COVID-19.Methods and resultsA consecutive sample of patients hospitalized with COVID-19 was prospectively included in this longitudinal study. All patients underwent an echocardiographic examination during hospitalization and 2 months later. All participants were successfully matched 1:1 with COVID-19-free controls by age and sex. A total of 91 patients were included (mean age 63 ± 12 years, 59% male). A median of 77 days (interquartile range: 72–92) passed between the two examinations. Right ventricular (RV) function improved following resolution of COVID-19: tricuspid annular plane systolic excursion (TAPSE) (2.28 ± 0.40 cm vs. 2.11 ± 0.38 cm, P < 0.001) and RV longitudinal strain (RVLS) (25.3 ± 5.5% vs. 19.9 ± 5.8%, P < 0.001). In contrast, left ventricular (LV) systolic function assessed by global longitudinal strain (GLS) did not significantly improve (17.4 ± 2.9% vs. 17.6 ± 3.3%, P = 0.6). N-terminal pro-B-type natriuretic peptide decreased between the two examinations [177.6 (80.3–408.0) ng/L vs. 11.7 (5.7–24.0) ng/L, P < 0.001]. None of the participants had elevated troponins at follow-up compared to 18 (27.7%) during hospitalization. Recovered COVID-19 patients had significantly lower GLS (17.4 ± 2.9% vs. 18.8 ± 2.9%, P < 0.001 and adjusted P = 0.004), TAPSE (2.28 ± 0.40 cm vs. 2.67 ± 0.44 cm, P < 0.001 and adjusted P < 0.001), and RVLS (25.3 ± 5.5% vs. 26.6 ± 5.8%, P = 0.50 and adjusted P < 0.001) compared to matched controls.ConclusionAcute COVID-19 affected negatively RV function and cardiac biomarkers but recovered following resolution of COVID-19. In contrast, the observed reduced LV function during acute COVID-19 did not improve post-COVID-19. Compared to the matched controls, both LV and RV function remained impaired.

AB - AimsThe degree of cardiovascular sequelae following COVID-19 remains unknown. The aim of this study was to investigate whether cardiac function recovers following COVID-19.Methods and resultsA consecutive sample of patients hospitalized with COVID-19 was prospectively included in this longitudinal study. All patients underwent an echocardiographic examination during hospitalization and 2 months later. All participants were successfully matched 1:1 with COVID-19-free controls by age and sex. A total of 91 patients were included (mean age 63 ± 12 years, 59% male). A median of 77 days (interquartile range: 72–92) passed between the two examinations. Right ventricular (RV) function improved following resolution of COVID-19: tricuspid annular plane systolic excursion (TAPSE) (2.28 ± 0.40 cm vs. 2.11 ± 0.38 cm, P < 0.001) and RV longitudinal strain (RVLS) (25.3 ± 5.5% vs. 19.9 ± 5.8%, P < 0.001). In contrast, left ventricular (LV) systolic function assessed by global longitudinal strain (GLS) did not significantly improve (17.4 ± 2.9% vs. 17.6 ± 3.3%, P = 0.6). N-terminal pro-B-type natriuretic peptide decreased between the two examinations [177.6 (80.3–408.0) ng/L vs. 11.7 (5.7–24.0) ng/L, P < 0.001]. None of the participants had elevated troponins at follow-up compared to 18 (27.7%) during hospitalization. Recovered COVID-19 patients had significantly lower GLS (17.4 ± 2.9% vs. 18.8 ± 2.9%, P < 0.001 and adjusted P = 0.004), TAPSE (2.28 ± 0.40 cm vs. 2.67 ± 0.44 cm, P < 0.001 and adjusted P < 0.001), and RVLS (25.3 ± 5.5% vs. 26.6 ± 5.8%, P = 0.50 and adjusted P < 0.001) compared to matched controls.ConclusionAcute COVID-19 affected negatively RV function and cardiac biomarkers but recovered following resolution of COVID-19. In contrast, the observed reduced LV function during acute COVID-19 did not improve post-COVID-19. Compared to the matched controls, both LV and RV function remained impaired.

KW - COVID-19

KW - follow-up

KW - recovery following COVID-19

KW - strain echocardiography

KW - COVID-19

KW - follow-up

KW - recovery following COVID-19

KW - strain echocardiography

U2 - 10.1002/ejhf.2347

DO - 10.1002/ejhf.2347

M3 - Journal article

C2 - 34514713

VL - 23

SP - 1903

EP - 1912

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

SN - 1567-4215

IS - 11

ER -