Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Journal of Physiology |
| Vol/bind | 543 |
| Udgave nummer | Pt 3 |
| Sider (fra-til) | 1033-46 |
| Antal sider | 13 |
| ISSN | 0022-3751 |
| Status | Udgivet - 2002 |
Bibliografisk note
Keywords: 3-Hydroxybutyric Acid; Abdomen; Acetates; Adipose Tissue; Adult; Carbon Isotopes; Deuterium; Esterification; Exercise; Fatty Acids; Glycerol; Humans; Liver; Male; Palmitates; Regional Blood Flow; Splanchnic Circulation; TriglyceridesCitationsformater
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I: Journal of Physiology, Bind 543, Nr. Pt 3, 2002, s. 1033-46.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Regional fat metabolism in human splanchnic and adipose tissues; the effect of exercise.
AU - Van Hall, Gerrit
AU - Bülow, Jens
AU - Sacchetti, Massimo
AU - Al Mulla, Nariman
AU - Lyngso, Dorthe
AU - Simonsen, Lene
N1 - Keywords: 3-Hydroxybutyric Acid; Abdomen; Acetates; Adipose Tissue; Adult; Carbon Isotopes; Deuterium; Esterification; Exercise; Fatty Acids; Glycerol; Humans; Liver; Male; Palmitates; Regional Blood Flow; Splanchnic Circulation; Triglycerides
PY - 2002
Y1 - 2002
N2 - This study was conducted to investigate the role of splanchnic and adipose tissue in the regulation of fatty acid (FA) metabolism at rest, during 1 h of semi-recumbent cycle exercise at 60 % of maximal power output and 3 h of recovery. In six post-absorptive healthy volunteers catheters were placed in a radial artery, hepatic vein and a subcutaneous vein on the anterior abdominal wall. Whole body, and regional splanchnic and adipose tissue FA metabolism were measured by a constant infusion of the stable isotopes [U-(13)C]palmitate and [(2)H(5)]glycerol and according to Fick's principle. The whole body rate of extracellular FA reesterification was similar at rest and during exercise (approximately 290 micromol min(-1)) and increased during recovery to a plateau of 390 micromol min(-1). FA and triacylglycerol (TAG) uptake by adipose tissue was undetectable, but a constant but small glycerol uptake of approximately 25 nmol (100 g)(-1) min(-1) was observed. From the FA taken up by the splanchnic area, 13 % was oxidized, 5-11 % converted to ketone bodies, and approximately 35 % incorporated in TAG released both at rest and at the third hour of recovery from exercise. Splanchnic FA reesterification could account for 51 % and 58 % of whole body extracellular FA reesterification, of which half was accounted for by TAG released from the splanchnic area, at rest and in recovery, respectively. In conclusion, in the post-absorptive state, adipose tissue contributes very little to extracellular FA reesterification and splanchnic reesterification can account for 50-60 %, implying that FA reesterification in other tissues is important. The extracellular FA reesterification rate does not change with exercise but is higher during recovery. Furthermore, the uptake of glycerol by adipose tissue indicates that adipose tissue can metabolize glycerol.
AB - This study was conducted to investigate the role of splanchnic and adipose tissue in the regulation of fatty acid (FA) metabolism at rest, during 1 h of semi-recumbent cycle exercise at 60 % of maximal power output and 3 h of recovery. In six post-absorptive healthy volunteers catheters were placed in a radial artery, hepatic vein and a subcutaneous vein on the anterior abdominal wall. Whole body, and regional splanchnic and adipose tissue FA metabolism were measured by a constant infusion of the stable isotopes [U-(13)C]palmitate and [(2)H(5)]glycerol and according to Fick's principle. The whole body rate of extracellular FA reesterification was similar at rest and during exercise (approximately 290 micromol min(-1)) and increased during recovery to a plateau of 390 micromol min(-1). FA and triacylglycerol (TAG) uptake by adipose tissue was undetectable, but a constant but small glycerol uptake of approximately 25 nmol (100 g)(-1) min(-1) was observed. From the FA taken up by the splanchnic area, 13 % was oxidized, 5-11 % converted to ketone bodies, and approximately 35 % incorporated in TAG released both at rest and at the third hour of recovery from exercise. Splanchnic FA reesterification could account for 51 % and 58 % of whole body extracellular FA reesterification, of which half was accounted for by TAG released from the splanchnic area, at rest and in recovery, respectively. In conclusion, in the post-absorptive state, adipose tissue contributes very little to extracellular FA reesterification and splanchnic reesterification can account for 50-60 %, implying that FA reesterification in other tissues is important. The extracellular FA reesterification rate does not change with exercise but is higher during recovery. Furthermore, the uptake of glycerol by adipose tissue indicates that adipose tissue can metabolize glycerol.
M3 - Journal article
C2 - 12231657
SN - 0022-3751
VL - 543
SP - 1033
EP - 1046
JO - Journal of Physiology
JF - Journal of Physiology
IS - Pt 3
ER -