Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Journal of Nuclear Medicine |
| Vol/bind | 39 |
| Udgave nummer | 1 |
| Sider (fra-til) | 176-80 |
| Antal sider | 4 |
| ISSN | 0161-5505 |
| Status | Udgivet - 1998 |
| Udgivet eksternt | Ja |
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I: Journal of Nuclear Medicine, Bind 39, Nr. 1, 1998, s. 176-80.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Regional lumped constant differences and asymmetry in fluorine-18-FDG uptake in temporal lobe epilepsy.
AU - Reutens, D C
AU - Gjedde, A H
AU - Meyer, E
PY - 1998
Y1 - 1998
N2 - To date, there has been no satisfactory explanation for the observation that interictal uptake of the glucose analog [18F]fluorodeoxyglucose (FDG) is consistently reduced in the temporal lobe ipsilateral to the seizure focus in patients with temporal lobe epilepsy. We examined the hypothesis that regional differences in tracer uptake in temporal lobe epilepsy reflect regional differences in the lumped constant (lambda). METHODS: In 9 control subjects and 10 patients with temporal lobe epilepsy, we obtained regional estimates of lambda by expressing lambda in terms of transfer coefficients for FDG and parameters which are likely to remain constant throughout both the brain and under different functional states. RESULTS: In the patients, lambda was lower in the temporal lobe ipsilateral to the epileptic focus (0.53 +/- 0.06; p < 0.005) than in the contralateral temporal lobe (0.56 +/- 0.06). Interside differences in lambda were highly correlated with asymmetry in tracer uptake. Furthermore, the use of regional estimates of lambda reduced the asymmetry in estimated rCMRglc in patients with temporal lobe epilepsy but not in controls. CONCLUSION: In these patients, a change in tracer uptake may not indicate a change in glucose consumption of corresponding magnitude, raising the possibility that in at least some patients with temporal lobe epilepsy, the term hypometabolism does not accurately describe reductions in tracer uptake.
AB - To date, there has been no satisfactory explanation for the observation that interictal uptake of the glucose analog [18F]fluorodeoxyglucose (FDG) is consistently reduced in the temporal lobe ipsilateral to the seizure focus in patients with temporal lobe epilepsy. We examined the hypothesis that regional differences in tracer uptake in temporal lobe epilepsy reflect regional differences in the lumped constant (lambda). METHODS: In 9 control subjects and 10 patients with temporal lobe epilepsy, we obtained regional estimates of lambda by expressing lambda in terms of transfer coefficients for FDG and parameters which are likely to remain constant throughout both the brain and under different functional states. RESULTS: In the patients, lambda was lower in the temporal lobe ipsilateral to the epileptic focus (0.53 +/- 0.06; p < 0.005) than in the contralateral temporal lobe (0.56 +/- 0.06). Interside differences in lambda were highly correlated with asymmetry in tracer uptake. Furthermore, the use of regional estimates of lambda reduced the asymmetry in estimated rCMRglc in patients with temporal lobe epilepsy but not in controls. CONCLUSION: In these patients, a change in tracer uptake may not indicate a change in glucose consumption of corresponding magnitude, raising the possibility that in at least some patients with temporal lobe epilepsy, the term hypometabolism does not accurately describe reductions in tracer uptake.
M3 - Journal article
C2 - 9443758
SN - 0161-5505
VL - 39
SP - 176
EP - 180
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
IS - 1
ER -