Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1

Zaklina Kovacevic, Sumit Sahni, K.H. Lok, M J Davies, D A Wink, Des R Richardson

Publikation: Bidrag til tidsskriftReviewForskningpeer review

32 Citationer (Scopus)

Abstract

We recently demonstrated that a novel storage and transport mechanism for nitric oxide (NO) mediated by glutathione-S-transferase P1 (GSTP1) and multidrug resistance protein 1 (MRP1/ABCC1), protects M1-macrophage (M1-MØ) models from large quantities of endogenous NO. This system stores and transports NO as dinitrosyl-dithiol-iron complexes (DNICs) composed of iron, NO and glutathione (GSH). Hence, this gas with contrasting anti- and pro-tumor effects, which has been assumed to be freely diffusible, is a tightly-regulated species in M1-MØs. These control systems prevent NO cytotoxicity and may be responsible for delivering cytotoxic NO as DNICs via MRP1 from M1-MØs, to tumor cell targets.

OriginalsprogEngelsk
TidsskriftB B A - Reviews on Cancer
Vol/bind1861
Udgave nummer5 Pt A
Sider (fra-til)995-999
Antal sider5
ISSN0006-3002
DOI
StatusUdgivet - maj 2017

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