@article{a5cb6870f85611ddb219000ea68e967b,
title = "Relatedness mapping and tracts of relatedness for genome-wide data in the presence of linkage disequilibrium",
abstract = "Estimates of relatedness have several applications such as the identification of relatives or in identifying disease related genes through identity by descent (IBD) mapping. Here we present a new method for identifying IBD tracts among individuals from genome-wide single nucleotide polymorphisms data. We use a continuous time Markov model where the hidden states are the number of alleles shared IBD between pairs of individuals at a given position. In contrast to previous methods, our method accurately accounts for linkage disequilibrium using pairwise haplotype probabilities. The method provides a map of the local relatedness along the genome. We illustrate the potential of the method for mapping disease genes on a real data set, and show that the method has the potential to map causative disease mutations using only a handful of affected individuals. The new IBD mapping method provides considerable improvement in mapping power in natural populations compared to standard association mapping methods. Genet. Epidemiol. 2008. (c) 2008 Wiley-Liss, Inc.",
author = "Anders Albrechtsen and Korneliussen, {Thorfinn Sand} and Ida Moltke and {van Overseem Hansen}, Thomas and Nielsen, {Finn Cilius} and Rasmus Nielsen",
note = "Keywords identity by descent • relatedness • hidden Markov model • linkage • association • complex disease • genome-wide analysis • SNP",
year = "2009",
doi = "10.1002/gepi.20378",
language = "English",
volume = "33",
pages = "266--274",
journal = "Genetic Epidemiology",
issn = "0741-0395",
publisher = "JohnWiley & Sons, Inc.",
number = "3",
}