TY - JOUR
T1 - Relationship between bisphenol A, bisphenol S, and bisphenol F and serum uric acid concentrations among school-aged children
AU - Lee, Yun Jeong
AU - Lim, Youn-Hee
AU - Shin, Choong Ho
AU - Kim, Bung-Nyun
AU - Kim, Johanna Inhyang
AU - Hong, Yun-Chul
AU - Cho, Yong Min
AU - Lee, Young Ah
PY - 2022
Y1 - 2022
N2 - BackgroundHyperuricemia has a suspected relationship with hypertension, metabolic syndrome, kidney disease, and cardiovascular disease. Endocrine disruptors may affect uric acid metabolism; however, few epidemiologic studies have been performed in children regarding newly developed bisphenol A (BPA) substitutes. We evaluated the associations between BPA, bisphenol S (BPS), and bisphenol F (BPF) exposure and serum uric acid concentrations in 6-year-old Korean children.MethodsFrom the Environment and Development of Children cohort study, six-year-old children (N = 489; 251 boys) who underwent an examination during 2015-2017 were included. Anthropometry, questionnaires, and biological samples were evaluated. BPA, BPS, and BPF levels were measured from spot urine samples, and log-transformed or categorized into groups for analysis. We constructed linear regression models adjusting for age, sex, urinary creatinine levels, body mass index z-scores, and estimated glomerular filtration rates.ResultsMean serum uric level was 4.2 mg dL(-1) (0.8 SD) without sex-differences. Among the three bisphenols, higher BPS exposure was associated with increased serum uric acid concentrations (P-value for trend = 0.002). When BPS levels were categorized into three groups (non-detection < 0.02 mu g L-1 vs. medium BPS; 0.02-0.05 mu g L-1 vs. high BPS > 0.05 mu g L-1), the high BPS group showed higher serum uric acid concentrations (by 0.26 mg dL(-1), P= 0.003) than the non-detection group after adjusting for covariates, which was significant in boys but not girls.DiscussionsUrinary BPS levels was positively associated with serum uric acid concentrations in 6-year-old children, and the association was more pronounced in boys. Considering the increasing use of BPS and concerning effect of hyperuricemia on health outcomes, their positive relationship should be investigated further.
AB - BackgroundHyperuricemia has a suspected relationship with hypertension, metabolic syndrome, kidney disease, and cardiovascular disease. Endocrine disruptors may affect uric acid metabolism; however, few epidemiologic studies have been performed in children regarding newly developed bisphenol A (BPA) substitutes. We evaluated the associations between BPA, bisphenol S (BPS), and bisphenol F (BPF) exposure and serum uric acid concentrations in 6-year-old Korean children.MethodsFrom the Environment and Development of Children cohort study, six-year-old children (N = 489; 251 boys) who underwent an examination during 2015-2017 were included. Anthropometry, questionnaires, and biological samples were evaluated. BPA, BPS, and BPF levels were measured from spot urine samples, and log-transformed or categorized into groups for analysis. We constructed linear regression models adjusting for age, sex, urinary creatinine levels, body mass index z-scores, and estimated glomerular filtration rates.ResultsMean serum uric level was 4.2 mg dL(-1) (0.8 SD) without sex-differences. Among the three bisphenols, higher BPS exposure was associated with increased serum uric acid concentrations (P-value for trend = 0.002). When BPS levels were categorized into three groups (non-detection < 0.02 mu g L-1 vs. medium BPS; 0.02-0.05 mu g L-1 vs. high BPS > 0.05 mu g L-1), the high BPS group showed higher serum uric acid concentrations (by 0.26 mg dL(-1), P= 0.003) than the non-detection group after adjusting for covariates, which was significant in boys but not girls.DiscussionsUrinary BPS levels was positively associated with serum uric acid concentrations in 6-year-old children, and the association was more pronounced in boys. Considering the increasing use of BPS and concerning effect of hyperuricemia on health outcomes, their positive relationship should be investigated further.
KW - NUTRITION EXAMINATION SURVEY
KW - URINARY CONCENTRATIONS
KW - BLOOD-PRESSURE
KW - METABOLIC SYNDROME
KW - OXIDATIVE STRESS
KW - NATIONAL-HEALTH
KW - UNITED-STATES
KW - HYPERURICEMIA
KW - EXPOSURE
KW - OBESITY
U2 - 10.1371/journal.pone.0268503
DO - 10.1371/journal.pone.0268503
M3 - Journal article
C2 - 35709251
VL - 17
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 6
M1 - 0268503
ER -