Relationship between type 1 diabetes and atopic diseases in a twin population

S F Thomsen; D L Duffy; K O Kyvik; A Skytthe; V Backer

doi:10.1111/j.1398-9995.2010.02517.x

Relationship between type 1 diabetes and atopic diseases in a twin population

S F Thomsen, D L Duffy, K O Kyvik, A Skytthe, V Backer

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

25 Citationer (Scopus)

Abstract

AIM:
To study the association between type 1 diabetes and atopic diseases in a twin population.
METHODS:
We performed record linkage between questionnaire-defined atopic dermatitis, asthma and hay fever, and hospital discharge diagnoses of type 1 diabetes in 54,530 Danish twins, 3-71 years of age.
RESULTS:
The age- and sex-adjusted risk of atopic dermatitis was decreased in subjects with type 1 diabetes compared with nondiabetic subjects, (2.1%vs 9.9%), odds ratio (OR)= 0.23 (0.07-0.71), P = 0.011, whereas asthma and hay fever were not significantly associated with type 1 diabetes. Within twin pairs discordant for type 1 diabetes, the diabetic twin had a lower risk of atopic dermatitis relative to the nondiabetic co-twin. Genetic factors for atopic dermatitis and type 1 diabetes were negatively correlated (r = -0.30), P = 0.0009.
CONCLUSIONS:
These findings substantiate the Th1 vs Th2 cell dichotomy for type 1 diabetes and atopic dermatitis, and indicate an inverse association between genetic factors for these disorders

Originalsprog	Engelsk
Tidsskrift	Allergy: European Journal of Allergy and Clinical Immunology
Vol/bind	66
Udgave nummer	5
Sider (fra-til)	645-7
Antal sider	3
ISSN	0105-4538
DOI	https://doi.org/10.1111/j.1398-9995.2010.02517.x https://doi.org/10.1111/j.1398-9995.2010.02517.x
Status	Udgivet - 1 maj 2011

Adgang til dokumentet

Citationsformater

@article{a38fa84632594c59b85ced70ee8ab32e,

title = "Relationship between type 1 diabetes and atopic diseases in a twin population",

abstract = "AIM: To study the association between type 1 diabetes and atopic diseases in a twin population.METHODS: We performed record linkage between questionnaire-defined atopic dermatitis, asthma and hay fever, and hospital discharge diagnoses of type 1 diabetes in 54,530 Danish twins, 3-71 years of age.RESULTS: The age- and sex-adjusted risk of atopic dermatitis was decreased in subjects with type 1 diabetes compared with nondiabetic subjects, (2.1%vs 9.9%), odds ratio (OR)= 0.23 (0.07-0.71), P = 0.011, whereas asthma and hay fever were not significantly associated with type 1 diabetes. Within twin pairs discordant for type 1 diabetes, the diabetic twin had a lower risk of atopic dermatitis relative to the nondiabetic co-twin. Genetic factors for atopic dermatitis and type 1 diabetes were negatively correlated (r = -0.30), P = 0.0009.CONCLUSIONS: These findings substantiate the Th1 vs Th2 cell dichotomy for type 1 diabetes and atopic dermatitis, and indicate an inverse association between genetic factors for these disorders",

author = "Thomsen, {S F} and Duffy, {D L} and Kyvik, {K O} and A Skytthe and V Backer",

note = "{\textcopyright} 2010 John Wiley & Sons A/S.",

year = "2011",

month = may,

day = "1",

doi = "10.1111/j.1398-9995.2010.02517.x",

language = "English",

volume = "66",

pages = "645--7",

journal = "Allergy: European Journal of Allergy and Clinical Immunology",

issn = "0105-4538",

publisher = "Wiley Online",

number = "5",

}

TY - JOUR

T1 - Relationship between type 1 diabetes and atopic diseases in a twin population

AU - Thomsen, S F

AU - Duffy, D L

AU - Kyvik, K O

AU - Skytthe, A

AU - Backer, V

PY - 2011/5/1

Y1 - 2011/5/1

N2 - AIM: To study the association between type 1 diabetes and atopic diseases in a twin population.METHODS: We performed record linkage between questionnaire-defined atopic dermatitis, asthma and hay fever, and hospital discharge diagnoses of type 1 diabetes in 54,530 Danish twins, 3-71 years of age.RESULTS: The age- and sex-adjusted risk of atopic dermatitis was decreased in subjects with type 1 diabetes compared with nondiabetic subjects, (2.1%vs 9.9%), odds ratio (OR)= 0.23 (0.07-0.71), P = 0.011, whereas asthma and hay fever were not significantly associated with type 1 diabetes. Within twin pairs discordant for type 1 diabetes, the diabetic twin had a lower risk of atopic dermatitis relative to the nondiabetic co-twin. Genetic factors for atopic dermatitis and type 1 diabetes were negatively correlated (r = -0.30), P = 0.0009.CONCLUSIONS: These findings substantiate the Th1 vs Th2 cell dichotomy for type 1 diabetes and atopic dermatitis, and indicate an inverse association between genetic factors for these disorders

AB - AIM: To study the association between type 1 diabetes and atopic diseases in a twin population.METHODS: We performed record linkage between questionnaire-defined atopic dermatitis, asthma and hay fever, and hospital discharge diagnoses of type 1 diabetes in 54,530 Danish twins, 3-71 years of age.RESULTS: The age- and sex-adjusted risk of atopic dermatitis was decreased in subjects with type 1 diabetes compared with nondiabetic subjects, (2.1%vs 9.9%), odds ratio (OR)= 0.23 (0.07-0.71), P = 0.011, whereas asthma and hay fever were not significantly associated with type 1 diabetes. Within twin pairs discordant for type 1 diabetes, the diabetic twin had a lower risk of atopic dermatitis relative to the nondiabetic co-twin. Genetic factors for atopic dermatitis and type 1 diabetes were negatively correlated (r = -0.30), P = 0.0009.CONCLUSIONS: These findings substantiate the Th1 vs Th2 cell dichotomy for type 1 diabetes and atopic dermatitis, and indicate an inverse association between genetic factors for these disorders

U2 - 10.1111/j.1398-9995.2010.02517.x

DO - 10.1111/j.1398-9995.2010.02517.x

M3 - Journal article

C2 - 21121932

VL - 66

SP - 645

EP - 647

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

IS - 5

ER -