Release and bioactivity of PACA nanoparticles containing D-Lys6-GnRH for brushtail possum fertility control

Alexandra P Kafka; Bernie J McLeod; Thomas Rades; Arlene McDowell

doi:10.1016/j.jconrel.2010.10.029

Release and bioactivity of PACA nanoparticles containing D-Lys6-GnRH for brushtail possum fertility control

Alexandra P Kafka, Bernie J McLeod, Thomas Rades, Arlene McDowell

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

17 Citationer (Scopus)

Abstract

Poly(ethylcyanoacrylate) (PECA) nanoparticles containing the chemical sterilitant D-Lys6-GnRH were prepared by an in situ interfacial polymerization technique. Their potential as a peroral delivery system for biocontrol of the brushtail possum, a major pest species in New Zealand, was evaluated. Peptide release from resulting particles was studied in vitro in artificial gastric juice (AGJ), simulated intestinal fluids (SIF) and brushtail possum plasma. The nanoparticles released a small fraction of bioactive over 6h in AGJ and SIF (

Originalsprog	Engelsk
Tidsskrift	Journal of controlled release : official journal of the Controlled Release Society
Vol/bind	149
Udgave nummer	3
Sider (fra-til)	307-13
Antal sider	7
DOI	https://doi.org/10.1016/j.jconrel.2010.10.029
Status	Udgivet - 2011
Udgivet eksternt	Ja

Adgang til dokumentet

10.1016/j.jconrel.2010.10.029

Citationsformater

Release and bioactivity of PACA nanoparticles containing D-Lys6-GnRH for brushtail possum fertility control. / Kafka, Alexandra P; McLeod, Bernie J; Rades, Thomas; McDowell, Arlene.

I: Journal of controlled release : official journal of the Controlled Release Society, Bind 149, Nr. 3, 2011, s. 307-13.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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abstract = "Poly(ethylcyanoacrylate) (PECA) nanoparticles containing the chemical sterilitant D-Lys6-GnRH were prepared by an in situ interfacial polymerization technique. Their potential as a peroral delivery system for biocontrol of the brushtail possum, a major pest species in New Zealand, was evaluated. Peptide release from resulting particles was studied in vitro in artificial gastric juice (AGJ), simulated intestinal fluids (SIF) and brushtail possum plasma. The nanoparticles released a small fraction of bioactive over 6h in AGJ and SIF (",

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AU - Rades, Thomas

AU - McDowell, Arlene

PY - 2011

Y1 - 2011

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AB - Poly(ethylcyanoacrylate) (PECA) nanoparticles containing the chemical sterilitant D-Lys6-GnRH were prepared by an in situ interfacial polymerization technique. Their potential as a peroral delivery system for biocontrol of the brushtail possum, a major pest species in New Zealand, was evaluated. Peptide release from resulting particles was studied in vitro in artificial gastric juice (AGJ), simulated intestinal fluids (SIF) and brushtail possum plasma. The nanoparticles released a small fraction of bioactive over 6h in AGJ and SIF (

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DO - 10.1016/j.jconrel.2010.10.029

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