Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine

A-L Esserlind; A F Christensen; H Le; M Kirchmann; A W Hauge; N M Toyserkani; Torben Hansen; Niels Grarup; T Werge; S Steinberg; F Bettella; H Stefansson; J Olesen

doi:10.1111/ene.12055

Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine

A-L Esserlind, A F Christensen, H Le, M Kirchmann, A W Hauge, N M Toyserkani, Torben Hansen, Niels Grarup, T Werge, S Steinberg, F Bettella, H Stefansson, J Olesen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

62 Citationer (Scopus)

Abstract

Genetic factors contribute to the aetiology of the prevalent form of migraine without aura (MO) and migraine with typical aura (MTA). Due to the complex inheritance of MO and MTA, the genetic background is still not fully established. In a population-based genome-wide association study by Chasman et al. (Nat Genet 2011: 43: 695-698), three common variants were found to confer risk of migraine at a genome-wide significant level (P <5 × 10(-8) ). We aimed to evaluate the top association single nucleotide polymorphisms (SNPs) from the discovery set by Chasman et al. in a primarily clinic-based Danish and Icelandic cohort.

Originalsprog	Engelsk
Tidsskrift	European Journal of Neurology
Vol/bind	20
Udgave nummer	5
Sider (fra-til)	765-772
Antal sider	8
ISSN	1351-5101
DOI	https://doi.org/10.1111/ene.12055
Status	Udgivet - maj 2013

Adgang til dokumentet

10.1111/ene.12055

Citationsformater

Esserlind, A-L., Christensen, A. F., Le, H., Kirchmann, M., Hauge, A. W., Toyserkani, N. M., Hansen, T., Grarup, N., Werge, T., Steinberg, S., Bettella, F., Stefansson, H., & Olesen, J. (2013). Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine. European Journal of Neurology, 20(5), 765-772. https://doi.org/10.1111/ene.12055

Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine. / Esserlind, A-L; Christensen, A F; Le, H; Kirchmann, M; Hauge, A W; Toyserkani, N M; Hansen, Torben; Grarup, Niels; Werge, T; Steinberg, S; Bettella, F; Stefansson, H; Olesen, J.

I: European Journal of Neurology, Bind 20, Nr. 5, 05.2013, s. 765-772.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Esserlind, A-L, Christensen, AF, Le, H, Kirchmann, M, Hauge, AW, Toyserkani, NM, Hansen, T, Grarup, N, Werge, T, Steinberg, S, Bettella, F, Stefansson, H & Olesen, J 2013, 'Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine', European Journal of Neurology, bind 20, nr. 5, s. 765-772. https://doi.org/10.1111/ene.12055

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title = "Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine",

abstract = "Genetic factors contribute to the aetiology of the prevalent form of migraine without aura (MO) and migraine with typical aura (MTA). Due to the complex inheritance of MO and MTA, the genetic background is still not fully established. In a population-based genome-wide association study by Chasman et al. (Nat Genet 2011: 43: 695-698), three common variants were found to confer risk of migraine at a genome-wide significant level (P <5 × 10(-8) ). We aimed to evaluate the top association single nucleotide polymorphisms (SNPs) from the discovery set by Chasman et al. in a primarily clinic-based Danish and Icelandic cohort.",

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AU - Esserlind, A-L

AU - Christensen, A F

AU - Le, H

AU - Kirchmann, M

AU - Hauge, A W

AU - Toyserkani, N M

AU - Hansen, Torben

AU - Grarup, Niels

AU - Werge, T

AU - Steinberg, S

AU - Bettella, F

AU - Stefansson, H

AU - Olesen, J

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N2 - Genetic factors contribute to the aetiology of the prevalent form of migraine without aura (MO) and migraine with typical aura (MTA). Due to the complex inheritance of MO and MTA, the genetic background is still not fully established. In a population-based genome-wide association study by Chasman et al. (Nat Genet 2011: 43: 695-698), three common variants were found to confer risk of migraine at a genome-wide significant level (P <5 × 10(-8) ). We aimed to evaluate the top association single nucleotide polymorphisms (SNPs) from the discovery set by Chasman et al. in a primarily clinic-based Danish and Icelandic cohort.

AB - Genetic factors contribute to the aetiology of the prevalent form of migraine without aura (MO) and migraine with typical aura (MTA). Due to the complex inheritance of MO and MTA, the genetic background is still not fully established. In a population-based genome-wide association study by Chasman et al. (Nat Genet 2011: 43: 695-698), three common variants were found to confer risk of migraine at a genome-wide significant level (P <5 × 10(-8) ). We aimed to evaluate the top association single nucleotide polymorphisms (SNPs) from the discovery set by Chasman et al. in a primarily clinic-based Danish and Icelandic cohort.

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DO - 10.1111/ene.12055

M3 - Journal article

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JF - European Journal of Neurology

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