@article{5abcb6a0df6911ddb5fc000ea68e967b,
title = "Requirement for CD40 ligand, CD4(+) T cells, and B cells in an infectious mononucleosis-like syndrome",
abstract = "Respiratory challenge with the murine gammaherpesvirus 68 (gammaHV-68) results in productive infection of the lung, the establishment of latency in B lymphocytes and other cell types, transient splenomegaly, and prolonged clonal expansion of activated CD8(+) CD62L(lo) T cells, particularly a Vbeta4(+) CD8(+) population that is found in mice with different major histocompatibility complex (MHC) haplotypes. Aspects of the CD8(+)-T-cell response are substantially modified in mice that lack B cells, CD4(+) T cells, or the CD40 ligand (CD40L). The B-cell-deficient mice show no increase in Vbeta4(+) CD8(+) T cells. Similar abrogation of the Vbeta4(+) CD8(+) response is seen following antibody-mediated depletion of the CD4(+) subset, through the numbers of CD8(+) CD62L(lo) cells are still significantly elevated. Virus-specific CD4(+)-T-cell frequencies are minimal in the CD40L(-/-) mice, and the Vbeta4(+) CD8(+) population remains unexpanded. Apparently B-cell-CD4(+)-T-cell interactions play a part in the gammaHV-68 induction of both splenomegaly and non-MHC-restricted Vbeta4(+) CD8(+)-T-cell expansion.",
author = "Brooks, {J W} and Hamilton-Easton, {A M} and Christensen, {J P} and Christensen, {Jan Pravsgaard} and Cardin, {R D} and Hardy, {C L} and Doherty, {P C}",
note = "Keywords: Animals; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD40 Ligand; CD8-Positive T-Lymphocytes; Female; Herpesvirus 4, Human; Infectious Mononucleosis; Leukocytes, Mononuclear; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Receptors, Antigen, T-Cell, alpha-beta; Spleen; Syndrome",
year = "1999",
language = "English",
volume = "73",
pages = "9650--4",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "11",
}