TY - JOUR
T1 - Residential exposure to transportation noise in Denmark and incidence of dementia
T2 - national cohort study
AU - Cantuaria, Manuella Lech
AU - Waldorff, Frans Boch
AU - Wermuth, Lene
AU - Pedersen, Ellen Raben
AU - Poulsen, Aslak Harbo
AU - Thacher, Jesse Daniel
AU - Raaschou-Nielsen, Ole
AU - Ketzel, Matthias
AU - Khan, Jibran
AU - Valencia, Victor H.
AU - Schmidt, Jesper Hvass
AU - Sørensen, Mette
PY - 2021
Y1 - 2021
N2 - OBJECTIVETo investigate the association between long term residential exposure to road traffic and railway noise and risk of incident dementia.DESIGNNationwide prospective register based cohort study.SETTINGDenmark.PARTICIPANTS1 938 994 adults aged >= 60 years living in Denmark between 1 January 2004 and 31 December 2017.MAIN OUTCOME MEASURESIncident cases of all cause dementia and dementia subtypes (Alzheimer's disease, vascular dementia, and Parkinson's disease related dementia), identified from national hospital and prescription registries.RESULTSThe study population included 103 500 participants with incident dementia, and of those, 31 219 received a diagnosis of Alzheimer's disease, 8664 of vascular dementia, and 2192 of Parkinson's disease related dementia. Using Cox regression models, 10 year mean exposure to road traffic and railway noise at the most (L(den)max) and least (L(den)min) exposed facades of buildings were associated with a higher risk of all cause dementia. These associations showed a general pattern of higher hazard ratios with higher noise exposure, but with a levelling off or even small declines in risk at higher noise levels. In subtype analyses, both road traffic noise and railway noise were associated with a higher risk of Alzheimer's disease, with hazard ratios of 1.16 (95% confidence interval 1.11 to 1.22) for road Ldenmax >= 65 dB compared with = 55 dB compared with = 60 dB compared with = 50 dB compared withCONCLUSIONSThis nationwide cohort study found transportation noise to be associated with a higher risk of all cause dementia and dementia subtypes, especially Alzheimer's disease.
AB - OBJECTIVETo investigate the association between long term residential exposure to road traffic and railway noise and risk of incident dementia.DESIGNNationwide prospective register based cohort study.SETTINGDenmark.PARTICIPANTS1 938 994 adults aged >= 60 years living in Denmark between 1 January 2004 and 31 December 2017.MAIN OUTCOME MEASURESIncident cases of all cause dementia and dementia subtypes (Alzheimer's disease, vascular dementia, and Parkinson's disease related dementia), identified from national hospital and prescription registries.RESULTSThe study population included 103 500 participants with incident dementia, and of those, 31 219 received a diagnosis of Alzheimer's disease, 8664 of vascular dementia, and 2192 of Parkinson's disease related dementia. Using Cox regression models, 10 year mean exposure to road traffic and railway noise at the most (L(den)max) and least (L(den)min) exposed facades of buildings were associated with a higher risk of all cause dementia. These associations showed a general pattern of higher hazard ratios with higher noise exposure, but with a levelling off or even small declines in risk at higher noise levels. In subtype analyses, both road traffic noise and railway noise were associated with a higher risk of Alzheimer's disease, with hazard ratios of 1.16 (95% confidence interval 1.11 to 1.22) for road Ldenmax >= 65 dB compared with = 55 dB compared with = 60 dB compared with = 50 dB compared withCONCLUSIONSThis nationwide cohort study found transportation noise to be associated with a higher risk of all cause dementia and dementia subtypes, especially Alzheimer's disease.
KW - AIR-POLLUTION
KW - TRAFFIC NOISE
KW - COGNITIVE IMPAIRMENT
KW - ALCOHOL-CONSUMPTION
KW - ROAD
KW - ANNOYANCE
KW - ASSOCIATION
KW - DISEASE
KW - STRESS
KW - RISK
U2 - 10.1136/bmj.n1954
DO - 10.1136/bmj.n1954
M3 - Journal article
C2 - 34497091
VL - 374
JO - British Medical Journal (Danish Edition)
JF - British Medical Journal (Danish Edition)
SN - 0959-535X
M1 - 1954
ER -