Restriction fragment length polymorphism of two HLA-B-associated transcripts genes in five autoimmune diseases

L Fugger; N Morling; L P Ryder; B K Jakobsen; V Andersen; P Oxholm; K Dalhoff; C Heilmann; F Karup Pedersen; J Friis

Restriction fragment length polymorphism of two HLA-B-associated transcripts genes in five autoimmune diseases

L Fugger, N Morling, L P Ryder, B K Jakobsen, V Andersen, P Oxholm, K Dalhoff, C Heilmann, F Karup Pedersen, J Friis

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

14 Citationer (Scopus)

Abstract

Udgivelsesdato: 1991-Jan

Originalsprog	Engelsk
Tidsskrift	Human Immunology
Vol/bind	30
Udgave nummer	1
Sider (fra-til)	27-31
Antal sider	4
ISSN	0198-8859
Status	Udgivet - 1991

Bibliografisk note

Keywords: Autoimmune Diseases; Genetic Markers; HLA-B Antigens; Humans; Liver Cirrhosis, Biliary; Lupus Erythematosus, Systemic; Polymorphism, Restriction Fragment Length; Sjogren's Syndrome; Transcription, Genetic

Citationsformater

@article{56be6110e4be11deba73000ea68e967b,

title = "Restriction fragment length polymorphism of two HLA-B-associated transcripts genes in five autoimmune diseases",

abstract = "The restriction fragment length polymorphism of the two human HLA-B-associated transcripts (BATs) genes, BAT1 and BAT2, identifying polymorphic bands of 12, 8, 2.5, and 1.1 kb, and at 3.3, 2.7, 2.3, and 0.9 kb, respectively, was investigated in patients with primary biliary cirrhosis (PBC), systemic lupus erythematosus (SLE), pauciarticular juvenile rheumatoid arthritis (P-JRA), rheumatoid arthritis (RA), and primary Sj{\"o}gren's syndrome (pSS), and in healthy Danes. The BAT2/RsaI 2.7-kb band fragment was more frequent in PBC, pSS, and SLE than in controls, but the p values did not reach significance when corrected for multiple comparisons. For pSS and SLE, the associations may be secondary to primary associations with HLA-B8 because the BAT2/RsaI 2.3-kb band, which is allelic to the BAT2/RsaI 2.7-kb band, is strongly negatively associated with HLA-B8 and HLA-DR3. The only significance obtained shows that the HLA-B8 frequency is increased in BAT2/RsaI 2.7-kb positive pSS patients as compared to the corresponding controls indicating that the HLA-B8 association may be strongest. No missing or extra DNA fragments were observed in the disease groups when compared with controls indicating that gross deletions or duplications of the BAT1 and BAT2 genes in the patients are unlikely. In conclusions, it cannot be excluded that the BAT2/RsaI 2.7-kb band may contribute to the susceptibility to PBC, pSS, and SLE.",

author = "L Fugger and N Morling and Ryder, {L P} and Jakobsen, {B K} and V Andersen and P Oxholm and K Dalhoff and C Heilmann and {Karup Pedersen}, F and J Friis",

note = "Keywords: Autoimmune Diseases; Genetic Markers; HLA-B Antigens; Humans; Liver Cirrhosis, Biliary; Lupus Erythematosus, Systemic; Polymorphism, Restriction Fragment Length; Sjogren's Syndrome; Transcription, Genetic",

year = "1991",

language = "English",

volume = "30",

pages = "27--31",

journal = "Human Immunology",

issn = "0198-8859",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Restriction fragment length polymorphism of two HLA-B-associated transcripts genes in five autoimmune diseases

AU - Fugger, L

AU - Morling, N

AU - Ryder, L P

AU - Jakobsen, B K

AU - Andersen, V

AU - Oxholm, P

AU - Dalhoff, K

AU - Heilmann, C

AU - Karup Pedersen, F

AU - Friis, J

N1 - Keywords: Autoimmune Diseases; Genetic Markers; HLA-B Antigens; Humans; Liver Cirrhosis, Biliary; Lupus Erythematosus, Systemic; Polymorphism, Restriction Fragment Length; Sjogren's Syndrome; Transcription, Genetic

PY - 1991

Y1 - 1991

N2 - The restriction fragment length polymorphism of the two human HLA-B-associated transcripts (BATs) genes, BAT1 and BAT2, identifying polymorphic bands of 12, 8, 2.5, and 1.1 kb, and at 3.3, 2.7, 2.3, and 0.9 kb, respectively, was investigated in patients with primary biliary cirrhosis (PBC), systemic lupus erythematosus (SLE), pauciarticular juvenile rheumatoid arthritis (P-JRA), rheumatoid arthritis (RA), and primary Sjögren's syndrome (pSS), and in healthy Danes. The BAT2/RsaI 2.7-kb band fragment was more frequent in PBC, pSS, and SLE than in controls, but the p values did not reach significance when corrected for multiple comparisons. For pSS and SLE, the associations may be secondary to primary associations with HLA-B8 because the BAT2/RsaI 2.3-kb band, which is allelic to the BAT2/RsaI 2.7-kb band, is strongly negatively associated with HLA-B8 and HLA-DR3. The only significance obtained shows that the HLA-B8 frequency is increased in BAT2/RsaI 2.7-kb positive pSS patients as compared to the corresponding controls indicating that the HLA-B8 association may be strongest. No missing or extra DNA fragments were observed in the disease groups when compared with controls indicating that gross deletions or duplications of the BAT1 and BAT2 genes in the patients are unlikely. In conclusions, it cannot be excluded that the BAT2/RsaI 2.7-kb band may contribute to the susceptibility to PBC, pSS, and SLE.

AB - The restriction fragment length polymorphism of the two human HLA-B-associated transcripts (BATs) genes, BAT1 and BAT2, identifying polymorphic bands of 12, 8, 2.5, and 1.1 kb, and at 3.3, 2.7, 2.3, and 0.9 kb, respectively, was investigated in patients with primary biliary cirrhosis (PBC), systemic lupus erythematosus (SLE), pauciarticular juvenile rheumatoid arthritis (P-JRA), rheumatoid arthritis (RA), and primary Sjögren's syndrome (pSS), and in healthy Danes. The BAT2/RsaI 2.7-kb band fragment was more frequent in PBC, pSS, and SLE than in controls, but the p values did not reach significance when corrected for multiple comparisons. For pSS and SLE, the associations may be secondary to primary associations with HLA-B8 because the BAT2/RsaI 2.3-kb band, which is allelic to the BAT2/RsaI 2.7-kb band, is strongly negatively associated with HLA-B8 and HLA-DR3. The only significance obtained shows that the HLA-B8 frequency is increased in BAT2/RsaI 2.7-kb positive pSS patients as compared to the corresponding controls indicating that the HLA-B8 association may be strongest. No missing or extra DNA fragments were observed in the disease groups when compared with controls indicating that gross deletions or duplications of the BAT1 and BAT2 genes in the patients are unlikely. In conclusions, it cannot be excluded that the BAT2/RsaI 2.7-kb band may contribute to the susceptibility to PBC, pSS, and SLE.

M3 - Journal article

C2 - 1672123

SN - 0198-8859

VL - 30

SP - 27

EP - 31

JO - Human Immunology

JF - Human Immunology

IS - 1

ER -