@article{d6d4853200304557b704106bbdcdb25d,
title = "Reversed binding of a small molecule ligand in homologous chemokine receptors - differential role of extracellular loop 2",
abstract = "The majority of small molecule compounds targeting chemokine receptors share a similar pharmacophore with a centrally located aliphatic positive charge and flanking aromatic moieties. Here we describe a novel piperidine-based compound with structural similarity to previously described CCR8-specific agonists, but containing a unique phenyl-tetrazol moiety which, in addition to activity at CCR8 was also active at CCR1.",
keywords = "Animals, Binding Sites, COS Cells, Cercopithecus aethiops, Glutamic Acid, Humans, Inositol 1,4,5-Trisphosphate, Ligands, Models, Molecular, Piperidines, Point Mutation, Receptors, CCR1, Receptors, CCR8, Tetrazoles",
author = "P.C. Jensen and S Thiele and A Steen and A Elder and R Kolbeck and Sudip Ghosh and Frimurer, {T M} and Rosenkilde, {Mette Marie}",
note = "{\textcopyright} 2011 The Authors. British Journal of Pharmacology {\textcopyright} 2011 The British Pharmacological Society.",
year = "2012",
month = may,
doi = "10.1111/j.1476-5381.2011.01771.x",
language = "English",
volume = "166",
pages = "258--75",
journal = "British Journal of Pharmacology",
issn = "0007-1188",
publisher = "Wiley",
number = "1",
}