RIFINs are adhesins implicated in severe Plasmodium falciparum malaria

Suchi Goel; Mia Palmkvist; Kirsten Moll; Nicolas Joannin; Patricia Lara; Reetesh R Akhouri; Nasim Moradi; Karin Öjemalm; Mattias Westman; Davide Angeletti; Hanna Kjellin; Janne Lehtiö; Klas Ola Blixt; Lars Ideström; Carl G. Gahmberg; Jill R. Storry; Annika K. Hult; Martin L. Olsson; Gunnar von Heijne; IngMarie Nilsson; Mats Wahlgren

doi:10.1038/nm.3812

RIFINs are adhesins implicated in severe Plasmodium falciparum malaria

Suchi Goel^*, Mia Palmkvist, Kirsten Moll, Nicolas Joannin, Patricia Lara, Reetesh R Akhouri, Nasim Moradi, Karin Öjemalm, Mattias Westman, Davide Angeletti, Hanna Kjellin, Janne Lehtiö, Klas Ola Blixt, Lars Ideström, Carl G. Gahmberg, Jill R. Storry, Annika K. Hult, Martin L. Olsson, Gunnar von Heijne, IngMarie NilssonMats Wahlgren

^*Corresponding author af dette arbejde

Kemisk Institut

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

160 Citationer (Scopus)

Abstract

Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum–encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), where they bind to RBCs—preferentially of blood group A—to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.

Originalsprog	Engelsk
Tidsskrift	Nature Medicine
Sider (fra-til)	314-317
Antal sider	8
ISSN	1078-8956
DOI	https://doi.org/10.1038/nm.3812
Status	Udgivet - 2015

Adgang til dokumentet

10.1038/nm.3812

Citationsformater

Goel, S., Palmkvist, M., Moll, K., Joannin, N., Lara, P., R Akhouri, R., Moradi, N., Öjemalm, K., Westman, M., Angeletti, D., Kjellin, H., Lehtiö, J., Blixt, K. O., Ideström, L., Gahmberg, C. G., Storry, J. R., Hult, A. K., Olsson, M. L., von Heijne, G., ... Wahlgren, M. (2015). RIFINs are adhesins implicated in severe Plasmodium falciparum malaria. Nature Medicine, 314-317. https://doi.org/10.1038/nm.3812

Goel, S, Palmkvist, M, Moll, K, Joannin, N, Lara, P, R Akhouri, R, Moradi, N, Öjemalm, K, Westman, M, Angeletti, D, Kjellin, H, Lehtiö, J, Blixt, KO, Ideström, L, Gahmberg, CG, Storry, JR, Hult, AK, Olsson, ML, von Heijne, G, Nilsson, I & Wahlgren, M 2015, 'RIFINs are adhesins implicated in severe Plasmodium falciparum malaria', Nature Medicine, s. 314-317. https://doi.org/10.1038/nm.3812

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title = "RIFINs are adhesins implicated in severe Plasmodium falciparum malaria",

abstract = "Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum–encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), where they bind to RBCs—preferentially of blood group A—to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.",

author = "Suchi Goel and Mia Palmkvist and Kirsten Moll and Nicolas Joannin and Patricia Lara and {R Akhouri}, Reetesh and Nasim Moradi and Karin {\"O}jemalm and Mattias Westman and Davide Angeletti and Hanna Kjellin and Janne Lehti{\"o} and Blixt, {Klas Ola} and Lars Idestr{\"o}m and Gahmberg, {Carl G.} and Storry, {Jill R.} and Hult, {Annika K.} and Olsson, {Martin L.} and {von Heijne}, Gunnar and IngMarie Nilsson and Mats Wahlgren",

year = "2015",

doi = "10.1038/nm.3812",

language = "English",

pages = "314--317",

journal = "Nature Medicine",

issn = "1078-8956",

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TY - JOUR

T1 - RIFINs are adhesins implicated in severe Plasmodium falciparum malaria

AU - Goel, Suchi

AU - Palmkvist, Mia

AU - Moll, Kirsten

AU - Joannin, Nicolas

AU - Lara, Patricia

AU - R Akhouri, Reetesh

AU - Moradi, Nasim

AU - Öjemalm, Karin

AU - Westman, Mattias

AU - Angeletti, Davide

AU - Kjellin, Hanna

AU - Lehtiö, Janne

AU - Blixt, Klas Ola

AU - Ideström, Lars

AU - Gahmberg, Carl G.

AU - Storry, Jill R.

AU - Hult, Annika K.

AU - Olsson, Martin L.

AU - von Heijne, Gunnar

AU - Nilsson, IngMarie

AU - Wahlgren, Mats

PY - 2015

Y1 - 2015

N2 - Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum–encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), where they bind to RBCs—preferentially of blood group A—to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.

AB - Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum–encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), where they bind to RBCs—preferentially of blood group A—to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.

U2 - 10.1038/nm.3812

DO - 10.1038/nm.3812

M3 - Journal article

C2 - 25751816

SN - 1078-8956

SP - 314

EP - 317

JO - Nature Medicine

JF - Nature Medicine

ER -