Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | JNCI - Journal of the National Cancer Institute |
| Vol/bind | 101 |
| Udgave nummer | 14 |
| Sider (fra-til) | 1012-8 |
| Antal sider | 7 |
| ISSN | 0027-8874 |
| DOI | |
| Status | Udgivet - 2009 |
Bibliografisk note
Keywords: Adult; Aged; Asian Continental Ancestry Group; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninfiltrating; Case-Control Studies; Confidence Intervals; Confounding Factors (Epidemiology); European Continental Ancestry Group; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Linkage Disequilibrium; Middle Aged; Neoplasms, Hormone-Dependent; Odds Ratio; Polymorphism, Single Nucleotide; Receptors, Estrogen; Receptors, Progesterone; Tumor Markers, BiologicalAdgang til dokumentet
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Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042. / Milne, Roger L; Benítez, Javier; Nevanlinna, Heli; Heikkinen, Tuomas; Aittomäki, Kristiina; Blomqvist, Carl; Arias, José Ignacio; Zamora, M Pilar; Burwinkel, Barbara; Bartram, Claus R; Meindl, Alfons; Schmutzler, Rita K; Cox, Angela; Brock, Ian; Elliott, Graeme; Reed, Malcolm W R; Southey, Melissa C; Smith, Letitia; Spurdle, Amanda B; Hopper, John L; Couch, Fergus J; Olson, Janet E; Wang, Xianshu; Fredericksen, Zachary; Schürmann, Peter; Bremer, Michael; Hillemanns, Peter; Dörk, Thilo; Devilee, Peter; van Asperen, Christie J; Tollenaar, Rob A E M; Seynaeve, Caroline; Hall, Per; Czene, Kamila; Liu, Jianjun; Li, Yuqing; Ahmed, Shahana; Dunning, Alison M; Maranian, Melanie; Pharoah, Paul D P; Chenevix-Trench, Georgia; Beesley, Jonathan; kConFab Investigators; AOCS Group; Bogdanova, Natalia V; Antonenkova, Natalia N; Zalutsky, Iosif V; Anton-Culver, Hoda; Ziogas, Argyrios; Brauch, Hiltrud; Bojesen, Stig E; Flyger, Henrik; Breast Cancer Association Consortium.
I: JNCI - Journal of the National Cancer Institute, Bind 101, Nr. 14, 2009, s. 1012-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042
AU - Milne, Roger L
AU - Benítez, Javier
AU - Nevanlinna, Heli
AU - Heikkinen, Tuomas
AU - Aittomäki, Kristiina
AU - Blomqvist, Carl
AU - Arias, José Ignacio
AU - Zamora, M Pilar
AU - Burwinkel, Barbara
AU - Bartram, Claus R
AU - Meindl, Alfons
AU - Schmutzler, Rita K
AU - Cox, Angela
AU - Brock, Ian
AU - Elliott, Graeme
AU - Reed, Malcolm W R
AU - Southey, Melissa C
AU - Smith, Letitia
AU - Spurdle, Amanda B
AU - Hopper, John L
AU - Couch, Fergus J
AU - Olson, Janet E
AU - Wang, Xianshu
AU - Fredericksen, Zachary
AU - Schürmann, Peter
AU - Bremer, Michael
AU - Hillemanns, Peter
AU - Dörk, Thilo
AU - Devilee, Peter
AU - van Asperen, Christie J
AU - Tollenaar, Rob A E M
AU - Seynaeve, Caroline
AU - Hall, Per
AU - Czene, Kamila
AU - Liu, Jianjun
AU - Li, Yuqing
AU - Ahmed, Shahana
AU - Dunning, Alison M
AU - Maranian, Melanie
AU - Pharoah, Paul D P
AU - Chenevix-Trench, Georgia
AU - Beesley, Jonathan
AU - kConFab Investigators
AU - AOCS Group
AU - Bogdanova, Natalia V
AU - Antonenkova, Natalia N
AU - Zalutsky, Iosif V
AU - Anton-Culver, Hoda
AU - Ziogas, Argyrios
AU - Brauch, Hiltrud
AU - Bojesen, Stig E
AU - Flyger, Henrik
AU - Breast Cancer Association Consortium
N1 - Keywords: Adult; Aged; Asian Continental Ancestry Group; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninfiltrating; Case-Control Studies; Confidence Intervals; Confounding Factors (Epidemiology); European Continental Ancestry Group; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Linkage Disequilibrium; Middle Aged; Neoplasms, Hormone-Dependent; Odds Ratio; Polymorphism, Single Nucleotide; Receptors, Estrogen; Receptors, Progesterone; Tumor Markers, Biological
PY - 2009
Y1 - 2009
N2 - BACKGROUND: A recent genome-wide association study identified single-nucleotide polymorphism (SNP) 2q35-rs13387042 as a marker of susceptibility to estrogen receptor (ER)-positive breast cancer. We attempted to confirm this association using the Breast Cancer Association Consortium. METHODS: 2q35-rs13387042 SNP was genotyped for 31 510 women with invasive breast cancer, 1101 women with ductal carcinoma in situ, and 35 969 female control subjects from 25 studies. Odds ratios (ORs) were estimated by logistic regression, adjusted for study. Heterogeneity in odds ratios by each of age, ethnicity, and study was assessed by fitting interaction terms. Heterogeneity by each of invasiveness, family history, bilaterality, and hormone receptor status was assessed by subclassifying case patients and applying polytomous logistic regression. All statistical tests were two-sided. RESULTS: We found strong evidence of association between rs13387042 and breast cancer in white women of European origin (per-allele OR = 1.12, 95% confidence interval [CI] = 1.09 to 1.15; P(trend) = 1.0 x 10(-19)). The odds ratio was lower than that previously reported (P = .02) and did not vary by age or ethnicity (all P > or = .2). However, it was higher when the analysis was restricted to case patients who were selected for a strong family history (P = .02). An association was observed for both ER-positive (OR = 1.14, 95% CI = 1.10 to 1.17; P = 10(-15)) and ER-negative disease (OR = 1.10, 95% CI = 1.04 to 1.15; P = .0003) and both progesterone receptor (PR)-positive (OR = 1.15, 95% CI = 1.11 to 1.19; P = 5 x 10(-14)) and PR-negative disease (OR = 1.10, 95% CI = 1.06 to 1.15; P = .00002). CONCLUSION: The rs13387042 is associated with both ER-positive and ER-negative breast cancer in European women.
AB - BACKGROUND: A recent genome-wide association study identified single-nucleotide polymorphism (SNP) 2q35-rs13387042 as a marker of susceptibility to estrogen receptor (ER)-positive breast cancer. We attempted to confirm this association using the Breast Cancer Association Consortium. METHODS: 2q35-rs13387042 SNP was genotyped for 31 510 women with invasive breast cancer, 1101 women with ductal carcinoma in situ, and 35 969 female control subjects from 25 studies. Odds ratios (ORs) were estimated by logistic regression, adjusted for study. Heterogeneity in odds ratios by each of age, ethnicity, and study was assessed by fitting interaction terms. Heterogeneity by each of invasiveness, family history, bilaterality, and hormone receptor status was assessed by subclassifying case patients and applying polytomous logistic regression. All statistical tests were two-sided. RESULTS: We found strong evidence of association between rs13387042 and breast cancer in white women of European origin (per-allele OR = 1.12, 95% confidence interval [CI] = 1.09 to 1.15; P(trend) = 1.0 x 10(-19)). The odds ratio was lower than that previously reported (P = .02) and did not vary by age or ethnicity (all P > or = .2). However, it was higher when the analysis was restricted to case patients who were selected for a strong family history (P = .02). An association was observed for both ER-positive (OR = 1.14, 95% CI = 1.10 to 1.17; P = 10(-15)) and ER-negative disease (OR = 1.10, 95% CI = 1.04 to 1.15; P = .0003) and both progesterone receptor (PR)-positive (OR = 1.15, 95% CI = 1.11 to 1.19; P = 5 x 10(-14)) and PR-negative disease (OR = 1.10, 95% CI = 1.06 to 1.15; P = .00002). CONCLUSION: The rs13387042 is associated with both ER-positive and ER-negative breast cancer in European women.
U2 - 10.1093/jnci/djp167
DO - 10.1093/jnci/djp167
M3 - Journal article
C2 - 19567422
VL - 101
SP - 1012
EP - 1018
JO - National Cancer Institute. Journal (Print)
JF - National Cancer Institute. Journal (Print)
SN - 0027-8874
IS - 14
ER -