Risk of triple-class virological failure in children with HIV: a retrospective cohort study

Hannah Castro; Ali Judd; Diana M Gibb; Karina Butler; Rebecca K Lodwick; Ard van Sighem; Jose T Ramos; Josiane Warsawski; Claire Thorne; Antoni Noguera-Julian; Niels Obel; Dominique Costagliola; Pat A Tookey; Céline Colin; Jesper Kjaer; Jesper Grarup; Genevieve Chene; Andrew Phillips; Pursuing Later Treatment Options II (PLATO II) project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE)

doi:10.1016/S0140-6736(11)60208-0

Risk of triple-class virological failure in children with HIV: a retrospective cohort study

Hannah Castro, Ali Judd, Diana M Gibb, Karina Butler, Rebecca K Lodwick, Ard van Sighem, Jose T Ramos, Josiane Warsawski, Claire Thorne, Antoni Noguera-Julian, Niels Obel, Dominique Costagliola, Pat A Tookey, Céline Colin, Jesper Kjaer, Jesper Grarup, Genevieve Chene, Andrew Phillips, Pursuing Later Treatment Options II (PLATO II) project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE)

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

95 Citationer (Scopus)

Abstract

In adults with HIV treated with antiretroviral drug regimens from within the three original drug classes (nucleoside or nucleotide reverse transcriptase inhibitors [NRTIs], non-NRTIs [NNRTIs], and protease inhibitors), virological failure occurs slowly, suggesting that long-term virological suppression can be achieved in most people, even in areas where access is restricted to drugs from these classes. It is unclear whether this is the case for children, the group who will need to maintain viral suppression for longest. We aimed to determine the rate and predictors of triple-class virological failure to the three original drugs classes in children.

Originalsprog	Engelsk
Tidsskrift	Lancet
Vol/bind	377
Udgave nummer	9777
Sider (fra-til)	1580-7
Antal sider	8
DOI	https://doi.org/10.1016/S0140-6736(11)60208-0
Status	Udgivet - 7 maj 2011

Adgang til dokumentet

10.1016/S0140-6736(11)60208-0

Citationsformater

Castro, H., Judd, A., Gibb, D. M., Butler, K., Lodwick, R. K., van Sighem, A., Ramos, J. T., Warsawski, J., Thorne, C., Noguera-Julian, A., Obel, N., Costagliola, D., Tookey, P. A., Colin, C., Kjaer, J., Grarup, J., Chene, G., Phillips, A., & Pursuing Later Treatment Options II (PLATO II) project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) (2011). Risk of triple-class virological failure in children with HIV: a retrospective cohort study. Lancet, 377(9777), 1580-7. https://doi.org/10.1016/S0140-6736(11)60208-0

Risk of triple-class virological failure in children with HIV: a retrospective cohort study. / Castro, Hannah; Judd, Ali; Gibb, Diana M; Butler, Karina; Lodwick, Rebecca K; van Sighem, Ard; Ramos, Jose T; Warsawski, Josiane; Thorne, Claire; Noguera-Julian, Antoni; Obel, Niels; Costagliola, Dominique; Tookey, Pat A; Colin, Céline; Kjaer, Jesper; Grarup, Jesper; Chene, Genevieve; Phillips, Andrew; Pursuing Later Treatment Options II (PLATO II) project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE).

I: Lancet, Bind 377, Nr. 9777, 07.05.2011, s. 1580-7.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Castro, H, Judd, A, Gibb, DM, Butler, K, Lodwick, RK, van Sighem, A, Ramos, JT, Warsawski, J, Thorne, C, Noguera-Julian, A, Obel, N, Costagliola, D, Tookey, PA, Colin, C, Kjaer, J, Grarup, J, Chene, G, Phillips, A & Pursuing Later Treatment Options II (PLATO II) project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) 2011, 'Risk of triple-class virological failure in children with HIV: a retrospective cohort study', Lancet, bind 377, nr. 9777, s. 1580-7. https://doi.org/10.1016/S0140-6736(11)60208-0

Castro, Hannah ; Judd, Ali ; Gibb, Diana M ; Butler, Karina ; Lodwick, Rebecca K ; van Sighem, Ard ; Ramos, Jose T ; Warsawski, Josiane ; Thorne, Claire ; Noguera-Julian, Antoni ; Obel, Niels ; Costagliola, Dominique ; Tookey, Pat A ; Colin, Céline ; Kjaer, Jesper ; Grarup, Jesper ; Chene, Genevieve ; Phillips, Andrew ; Pursuing Later Treatment Options II (PLATO II) project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE). / Risk of triple-class virological failure in children with HIV: a retrospective cohort study. I: Lancet. 2011 ; Bind 377, Nr. 9777. s. 1580-7.

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abstract = "In adults with HIV treated with antiretroviral drug regimens from within the three original drug classes (nucleoside or nucleotide reverse transcriptase inhibitors [NRTIs], non-NRTIs [NNRTIs], and protease inhibitors), virological failure occurs slowly, suggesting that long-term virological suppression can be achieved in most people, even in areas where access is restricted to drugs from these classes. It is unclear whether this is the case for children, the group who will need to maintain viral suppression for longest. We aimed to determine the rate and predictors of triple-class virological failure to the three original drugs classes in children.",

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author = "Hannah Castro and Ali Judd and Gibb, {Diana M} and Karina Butler and Lodwick, {Rebecca K} and {van Sighem}, Ard and Ramos, {Jose T} and Josiane Warsawski and Claire Thorne and Antoni Noguera-Julian and Niels Obel and Dominique Costagliola and Tookey, {Pat A} and C{\'e}line Colin and Jesper Kjaer and Jesper Grarup and Genevieve Chene and Andrew Phillips and {Pursuing Later Treatment Options II (PLATO II) project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE)}",

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T1 - Risk of triple-class virological failure in children with HIV: a retrospective cohort study

AU - Castro, Hannah

AU - Judd, Ali

AU - Gibb, Diana M

AU - Butler, Karina

AU - Lodwick, Rebecca K

AU - van Sighem, Ard

AU - Ramos, Jose T

AU - Warsawski, Josiane

AU - Thorne, Claire

AU - Noguera-Julian, Antoni

AU - Obel, Niels

AU - Costagliola, Dominique

AU - Tookey, Pat A

AU - Colin, Céline

AU - Kjaer, Jesper

AU - Grarup, Jesper

AU - Chene, Genevieve

AU - Phillips, Andrew

AU - Pursuing Later Treatment Options II (PLATO II) project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE)

PY - 2011/5/7

Y1 - 2011/5/7

N2 - In adults with HIV treated with antiretroviral drug regimens from within the three original drug classes (nucleoside or nucleotide reverse transcriptase inhibitors [NRTIs], non-NRTIs [NNRTIs], and protease inhibitors), virological failure occurs slowly, suggesting that long-term virological suppression can be achieved in most people, even in areas where access is restricted to drugs from these classes. It is unclear whether this is the case for children, the group who will need to maintain viral suppression for longest. We aimed to determine the rate and predictors of triple-class virological failure to the three original drugs classes in children.

AB - In adults with HIV treated with antiretroviral drug regimens from within the three original drug classes (nucleoside or nucleotide reverse transcriptase inhibitors [NRTIs], non-NRTIs [NNRTIs], and protease inhibitors), virological failure occurs slowly, suggesting that long-term virological suppression can be achieved in most people, even in areas where access is restricted to drugs from these classes. It is unclear whether this is the case for children, the group who will need to maintain viral suppression for longest. We aimed to determine the rate and predictors of triple-class virological failure to the three original drugs classes in children.

KW - Adolescent

KW - Anti-Retroviral Agents

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Female

KW - HIV Infections

KW - Humans

KW - Infant

KW - Infectious Disease Transmission, Vertical

KW - Kaplan-Meier Estimate

KW - Male

KW - Proportional Hazards Models

KW - Retrospective Studies

KW - Risk

KW - Treatment Failure

KW - Viral Load

U2 - 10.1016/S0140-6736(11)60208-0

DO - 10.1016/S0140-6736(11)60208-0

M3 - Journal article

C2 - 21511330

VL - 377

SP - 1580

EP - 1587

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 9777

ER -