Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia

Tadeusz Robak, Anna Dmoszynska, Philippe Solal-Céligny, Krzysztof Warzocha, Javier Loscertales, John Catalano, Boris V Afanasiev, Loree Larratt, Christian H Geisler, Marco Montillo, Ilya Zyuzgin, Peter S Ganly, Caroline Dartigeas, András Rosta, Jörg Maurer, Myriam Mendila, M Wayne Saville, Nancy Valente, Michael K Wenger, Sergey I Moiseev

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Abstract

Rituximab, a monoclonal antibody that targets the CD20 cell surface antigen, has clinical activity in patients with non-Hodgkin's lymphoma and other B-lymphocyte disorders when administered alone or in combination with chemotherapy. Promising results have previously been reported in nonrandomized studies in patients with chronic lymphocytic leukemia (CLL). This trial was designed to compare chemoimmunotherapy with chemotherapy alone in patients with previously treated CLL.
OriginalsprogEngelsk
TidsskriftJournal of Clinical Oncology
Vol/bind28
Udgave nummer10
Sider (fra-til)1756-65
Antal sider10
ISSN0732-183X
DOI
StatusUdgivet - 1 apr. 2010

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