Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Prostaglandins & Other Lipid Mediators |
| Vol/bind | 82 |
| Udgave nummer | 1-4 |
| Sider (fra-til) | 128-34 |
| Antal sider | 6 |
| ISSN | 1098-8823 |
| DOI | |
| Status | Udgivet - 2007 |
| Udgivet eksternt | Ja |
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Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation. / Fürstenberger, Gerhard; Epp, Nikolas; Eckl, Katja-Martina; Hennies, Hans Christian; Hallenborg, Philip; Kristiansen, Karsten; Jørgensen, Claus; Krieg, Peter.
I: Prostaglandins & Other Lipid Mediators, Bind 82, Nr. 1-4, 2007, s. 128-34.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation
AU - Fürstenberger, Gerhard
AU - Epp, Nikolas
AU - Eckl, Katja-Martina
AU - Hennies, Hans Christian
AU - Hallenborg, Philip
AU - Kristiansen, Karsten
AU - Jørgensen, Claus
AU - Krieg, Peter
PY - 2007
Y1 - 2007
N2 - 12R-lipoxygenase (12R-LOX) and epidermis-type LOX-3 (eLOX-3) are novel members of the multigene family of mammalian LOX. A considerable gap exists between the identification of these enzymes and their biologic function. Here, we present evidence that 12R-LOX and eLOX-3, acting in sequence, and eLOX-3 in combination with another, not yet identified LOX are critically involved in terminal differentiation of keratinocytes and adipocytes, respectively. Mutational inactivation of 12R-LOX and/or eLOX-3 has been found to be associated with development of an inherited ichthyosiform skin disorder in humans and genetic ablation of 12R-LOX causes a severe impairment of the epidermal lipid barrier in mice leading to post-natal death of the animals. In preadipocytes, a LOX-dependent PPARgamma activating ligand is released into the cell supernatant early upon induction of differentiation and available evidence indicates that this ligand is an eLOX-3-derived product. In accordance with this data is the observation that forced expression of eLOX-3 enhances adipocyte differentiation.
AB - 12R-lipoxygenase (12R-LOX) and epidermis-type LOX-3 (eLOX-3) are novel members of the multigene family of mammalian LOX. A considerable gap exists between the identification of these enzymes and their biologic function. Here, we present evidence that 12R-LOX and eLOX-3, acting in sequence, and eLOX-3 in combination with another, not yet identified LOX are critically involved in terminal differentiation of keratinocytes and adipocytes, respectively. Mutational inactivation of 12R-LOX and/or eLOX-3 has been found to be associated with development of an inherited ichthyosiform skin disorder in humans and genetic ablation of 12R-LOX causes a severe impairment of the epidermal lipid barrier in mice leading to post-natal death of the animals. In preadipocytes, a LOX-dependent PPARgamma activating ligand is released into the cell supernatant early upon induction of differentiation and available evidence indicates that this ligand is an eLOX-3-derived product. In accordance with this data is the observation that forced expression of eLOX-3 enhances adipocyte differentiation.
U2 - 10.1016/j.prostaglandins.2006.05.006
DO - 10.1016/j.prostaglandins.2006.05.006
M3 - Journal article
C2 - 17164140
VL - 82
SP - 128
EP - 134
JO - Prostaglandins and Other Lipid Mediators
JF - Prostaglandins and Other Lipid Mediators
SN - 1098-8823
IS - 1-4
ER -