@article{667a5860832b11de8bc9000ea68e967b,
title = "Role of metallothionein-III following central nervous system damage",
abstract = "We evaluated the physiological relevance of metallothionein-III (MT-III) in the central nervous system following damage caused by a focal cryolesion onto the cortex by studying Mt3-null mice. In normal mice, dramatic astrogliosis and microgliosis and T-cell infiltration were observed in the area surrounding the lesioned tissue, along with signs of increased oxidative stress and apoptosis. There was also significant upregulation of cytokines/growth factors such as tumor necrosis factor-alpha, interleukin (IL)-1 alpha/beta, and IL-6 as measured by ribonuclease protection assay. Mt3-null mice did not differ from control mice in these responses, in sharp contrast to results obtained in Mt1- Mt2-null mice. In contrast, Mt3-null mice showed increased expression of several neurotrophins as well as of the neuronal sprouting factor GAP-43. Thus, unlike MT-I and MT-II, MT-III does not affect the inflammatory response elicited in the central nervous system by a cryoinjury, nor does it serve an important antioxidant role, but it may influence neuronal regeneration during the recovery process.",
author = "Javier Carrasco and Milena Penkowa and Mercedes Giralt and Jordi Camats and Amalia Molinero and Campbell, {Iain L} and Palmiter, {Richard D} and Juan Hidalgo",
note = "Keywords: Animals; Apoptosis; Brain Injuries; Cell Count; Cerebral Cortex; Cytokines; Freezing; GAP-43 Protein; Gene Expression Regulation; Gliosis; Metallothionein; Mice; Mice, Inbred Strains; Mice, Knockout; Nerve Growth Factors; Nerve Tissue Proteins; Oxidative Stress; T-Lymphocytes",
year = "2003",
language = "English",
volume = "13",
pages = "22--36",
journal = "Neurobiology of Disease",
issn = "0969-9961",
publisher = "Academic Press",
number = "1",
}