Roles of different subtypes of opioid receptors in mediating the ventrolateral orbital cortex opioid-induced inhibition of mirror-neuropathic pain in the rat.

M Zhao; Junyang Wang; H Jia; J S Tang

doi:10.1016/j.neuroscience.2006.11.009

Roles of different subtypes of opioid receptors in mediating the ventrolateral orbital cortex opioid-induced inhibition of mirror-neuropathic pain in the rat.

M Zhao, Junyang Wang, H Jia, J S Tang

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

19 Citationer (Scopus)

Abstract

Udgivelsesdato: 2007-Feb-23

Originalsprog	Engelsk
Tidsskrift	Neuroscience
Vol/bind	144
Udgave nummer	4
Sider (fra-til)	1486-94
Antal sider	8
ISSN	0306-4522
DOI	https://doi.org/10.1016/j.neuroscience.2006.11.009
Status	Udgivet - 2006
Udgivet eksternt	Ja

Bibliografisk note

Keywords: Afferent Pathways; Analgesics, Opioid; Animals; Functional Laterality; Hyperalgesia; Ligation; Male; Morphine; Narcotic Antagonists; Nociceptors; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Nerves

Adgang til dokumentet

10.1016/j.neuroscience.2006.11.009

Citationsformater

@article{d688556057e111dd8d9f000ea68e967b,

title = "Roles of different subtypes of opioid receptors in mediating the ventrolateral orbital cortex opioid-induced inhibition of mirror-neuropathic pain in the rat.",

abstract = "Previous studies have demonstrated that opioid receptors in the prefrontal ventrolateral orbital cortex (VLO) are involved in anti-nociception. The aim of this current study was to examine whether opioid receptors in the VLO have effects on the hypersensitivity induced by contralateral L5 and L6 spinal nerve ligation (SNL), termed as mirror neuropathic pain (MNP) in the male rat. Morphine (1.0, 2.5, 5.0 microg) microinjected into the VLO contralateral to the SNL depressed the mechanical paw withdrawal assessed by von Frey filaments and the cold plate (4 degrees C)-induced paw lifting in a dose-dependent manner on the side without SNL. These effects were antagonized by microinjection of the non-selective opioid receptor antagonist naloxone (1.0 mug) into the same VLO site. Microinjection of endomorphin-1 (5.0 microg), a highly selective mu-opioid receptor agonist, and [d-Ala(2), d-Leu(5)]-enkephalin (DADLE, 10 microg), a delta-/mu-receptor agonist, also depressed the MNP. The effects of both drugs were blocked by selective mu-receptor antagonist beta-funaltrexamine (beta-FNA, 3.75 microg), but the effect of the DADLE was not influenced by the selective delta-receptor antagonist naltrindole (5.0 microg). Microinjection of the kappa-opioid receptor agonist spiradoline mesylate salt (U-62066) (100 microg) had no effect on the MNP. These results suggest that the VLO is involved in opioid-induced inhibition of the MNP and the effect is mediated by mu- (but not delta- and kappa-) opioid receptors.",

author = "M Zhao and Junyang Wang and H Jia and Tang, {J S}",

note = "Keywords: Afferent Pathways; Analgesics, Opioid; Animals; Functional Laterality; Hyperalgesia; Ligation; Male; Morphine; Narcotic Antagonists; Nociceptors; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Nerves",

year = "2006",

doi = "10.1016/j.neuroscience.2006.11.009",

language = "English",

volume = "144",

pages = "1486--94",

journal = "Neuroscience",

issn = "0306-4522",

publisher = "Pergamon Press",

number = "4",

}

TY - JOUR

T1 - Roles of different subtypes of opioid receptors in mediating the ventrolateral orbital cortex opioid-induced inhibition of mirror-neuropathic pain in the rat.

AU - Zhao, M

AU - Wang, Junyang

AU - Jia, H

AU - Tang, J S

N1 - Keywords: Afferent Pathways; Analgesics, Opioid; Animals; Functional Laterality; Hyperalgesia; Ligation; Male; Morphine; Narcotic Antagonists; Nociceptors; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Nerves

PY - 2006

Y1 - 2006

N2 - Previous studies have demonstrated that opioid receptors in the prefrontal ventrolateral orbital cortex (VLO) are involved in anti-nociception. The aim of this current study was to examine whether opioid receptors in the VLO have effects on the hypersensitivity induced by contralateral L5 and L6 spinal nerve ligation (SNL), termed as mirror neuropathic pain (MNP) in the male rat. Morphine (1.0, 2.5, 5.0 microg) microinjected into the VLO contralateral to the SNL depressed the mechanical paw withdrawal assessed by von Frey filaments and the cold plate (4 degrees C)-induced paw lifting in a dose-dependent manner on the side without SNL. These effects were antagonized by microinjection of the non-selective opioid receptor antagonist naloxone (1.0 mug) into the same VLO site. Microinjection of endomorphin-1 (5.0 microg), a highly selective mu-opioid receptor agonist, and [d-Ala(2), d-Leu(5)]-enkephalin (DADLE, 10 microg), a delta-/mu-receptor agonist, also depressed the MNP. The effects of both drugs were blocked by selective mu-receptor antagonist beta-funaltrexamine (beta-FNA, 3.75 microg), but the effect of the DADLE was not influenced by the selective delta-receptor antagonist naltrindole (5.0 microg). Microinjection of the kappa-opioid receptor agonist spiradoline mesylate salt (U-62066) (100 microg) had no effect on the MNP. These results suggest that the VLO is involved in opioid-induced inhibition of the MNP and the effect is mediated by mu- (but not delta- and kappa-) opioid receptors.

AB - Previous studies have demonstrated that opioid receptors in the prefrontal ventrolateral orbital cortex (VLO) are involved in anti-nociception. The aim of this current study was to examine whether opioid receptors in the VLO have effects on the hypersensitivity induced by contralateral L5 and L6 spinal nerve ligation (SNL), termed as mirror neuropathic pain (MNP) in the male rat. Morphine (1.0, 2.5, 5.0 microg) microinjected into the VLO contralateral to the SNL depressed the mechanical paw withdrawal assessed by von Frey filaments and the cold plate (4 degrees C)-induced paw lifting in a dose-dependent manner on the side without SNL. These effects were antagonized by microinjection of the non-selective opioid receptor antagonist naloxone (1.0 mug) into the same VLO site. Microinjection of endomorphin-1 (5.0 microg), a highly selective mu-opioid receptor agonist, and [d-Ala(2), d-Leu(5)]-enkephalin (DADLE, 10 microg), a delta-/mu-receptor agonist, also depressed the MNP. The effects of both drugs were blocked by selective mu-receptor antagonist beta-funaltrexamine (beta-FNA, 3.75 microg), but the effect of the DADLE was not influenced by the selective delta-receptor antagonist naltrindole (5.0 microg). Microinjection of the kappa-opioid receptor agonist spiradoline mesylate salt (U-62066) (100 microg) had no effect on the MNP. These results suggest that the VLO is involved in opioid-induced inhibition of the MNP and the effect is mediated by mu- (but not delta- and kappa-) opioid receptors.

U2 - 10.1016/j.neuroscience.2006.11.009

DO - 10.1016/j.neuroscience.2006.11.009

M3 - Journal article

C2 - 17184926

SN - 0306-4522

VL - 144

SP - 1486

EP - 1494

JO - Neuroscience

JF - Neuroscience

IS - 4

ER -