RTS,S/AS02A Malaria Vaccine-Induced IgG Responses Equally Recognize Native-Like Fucosylated and Nonfucosylated Plasmodium falciparum Circumsporozoite Proteins

Chenjerai Jairoce; Dídac Macià; Jorge P. Torres-Yaguana; Leonie Mayer; Marta Vidal; Rebeca Santano; Ramón Hurtado-Guerrero; Karine Reiter; David L. Narum; Borja Lopez-Gutierrez; Timothy Hamerly; Jahit Sacarlal; Ruth Aguilar; Rhoel R. Dinglasan; Gemma Moncunill; Luis Izquierdo; Carlota Dobaño

doi:10.1093/infdis/jiad471

RTS,S/AS02A Malaria Vaccine-Induced IgG Responses Equally Recognize Native-Like Fucosylated and Nonfucosylated Plasmodium falciparum Circumsporozoite Proteins

Chenjerai Jairoce, Dídac Macià, Jorge P. Torres-Yaguana, Leonie Mayer, Marta Vidal, Rebeca Santano, Ramón Hurtado-Guerrero, Karine Reiter, David L. Narum, Borja Lopez-Gutierrez, Timothy Hamerly, Jahit Sacarlal, Ruth Aguilar, Rhoel R. Dinglasan, Gemma Moncunill, Luis Izquierdo^*, Carlota Dobaño

^*Corresponding author af dette arbejde

Glycomics Program

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

The RTS,S/AS02A malaria vaccine is based on the Plasmodium falciparum circumsporozoite protein (PfCSP), which is O-fucosylated on the sporozoite surface. We determined whether RTS,S/AS02A-induced immunoglobulin G (IgG) antibodies recognize vaccine-like nonfucosylated PfCSP better than native-like fucosylated PfCSP. Similar to previous vaccine trials, RTS,S/AS02A vaccination induced high anti-PfCSP IgG levels associated with malaria protection. IgG recognition of nonfucosylated and fucosylated PfCSP was equivalent, suggesting that PfCSP fucosylation does not affect antibody recognition.

Originalsprog	Engelsk
Tidsskrift	Journal of Infectious Diseases
Vol/bind	229
Udgave nummer	3
Sider (fra-til)	795-799
Antal sider	5
ISSN	0022-1899
DOI	https://doi.org/10.1093/infdis/jiad471
Status	Udgivet - 2024

Bibliografisk note

Publisher Copyright:
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Adgang til dokumentet

10.1093/infdis/jiad471

Citationsformater

Jairoce, C., Macià, D., Torres-Yaguana, J. P., Mayer, L., Vidal, M., Santano, R., Hurtado-Guerrero, R., Reiter, K., Narum, D. L., Lopez-Gutierrez, B., Hamerly, T., Sacarlal, J., Aguilar, R., Dinglasan, R. R., Moncunill, G., Izquierdo, L., & Dobaño, C. (2024). RTS,S/AS02A Malaria Vaccine-Induced IgG Responses Equally Recognize Native-Like Fucosylated and Nonfucosylated Plasmodium falciparum Circumsporozoite Proteins. Journal of Infectious Diseases, 229(3), 795-799. https://doi.org/10.1093/infdis/jiad471

RTS,S/AS02A Malaria Vaccine-Induced IgG Responses Equally Recognize Native-Like Fucosylated and Nonfucosylated Plasmodium falciparum Circumsporozoite Proteins. / Jairoce, Chenjerai; Macià, Dídac; Torres-Yaguana, Jorge P. et al.
I: Journal of Infectious Diseases, Bind 229, Nr. 3, 2024, s. 795-799.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Jairoce, C, Macià, D, Torres-Yaguana, JP, Mayer, L, Vidal, M, Santano, R, Hurtado-Guerrero, R, Reiter, K, Narum, DL, Lopez-Gutierrez, B, Hamerly, T, Sacarlal, J, Aguilar, R, Dinglasan, RR, Moncunill, G, Izquierdo, L & Dobaño, C 2024, 'RTS,S/AS02A Malaria Vaccine-Induced IgG Responses Equally Recognize Native-Like Fucosylated and Nonfucosylated Plasmodium falciparum Circumsporozoite Proteins', Journal of Infectious Diseases, bind 229, nr. 3, s. 795-799. https://doi.org/10.1093/infdis/jiad471

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title = "RTS,S/AS02A Malaria Vaccine-Induced IgG Responses Equally Recognize Native-Like Fucosylated and Nonfucosylated Plasmodium falciparum Circumsporozoite Proteins",

abstract = "The RTS,S/AS02A malaria vaccine is based on the Plasmodium falciparum circumsporozoite protein (PfCSP), which is O-fucosylated on the sporozoite surface. We determined whether RTS,S/AS02A-induced immunoglobulin G (IgG) antibodies recognize vaccine-like nonfucosylated PfCSP better than native-like fucosylated PfCSP. Similar to previous vaccine trials, RTS,S/ AS02A vaccination induced high anti-PfCSP IgG levels associated with malaria protection. IgG recognition of nonfucosylated and fucosylated PfCSP was equivalent, suggesting that PfCSP fucosylation does not affect antibody recognition.",

keywords = "antibodies, circumsporozoite protein (PfCSP), fucosylation, immunogenicity, malaria, Plasmodium falciparum, RTS,S",

author = "Chenjerai Jairoce and D{\'i}dac Maci{\`a} and Torres-Yaguana, {Jorge P.} and Leonie Mayer and Marta Vidal and Rebeca Santano and Ram{\'o}n Hurtado-Guerrero and Karine Reiter and Narum, {David L.} and Borja Lopez-Gutierrez and Timothy Hamerly and Jahit Sacarlal and Ruth Aguilar and Dinglasan, {Rhoel R.} and Gemma Moncunill and Luis Izquierdo and Carlota Doba{\~n}o",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2024",

doi = "10.1093/infdis/jiad471",

language = "English",

volume = "229",

pages = "795--799",

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T1 - RTS,S/AS02A Malaria Vaccine-Induced IgG Responses Equally Recognize Native-Like Fucosylated and Nonfucosylated Plasmodium falciparum Circumsporozoite Proteins

AU - Jairoce, Chenjerai

AU - Macià, Dídac

AU - Torres-Yaguana, Jorge P.

AU - Mayer, Leonie

AU - Vidal, Marta

AU - Santano, Rebeca

AU - Hurtado-Guerrero, Ramón

AU - Reiter, Karine

AU - Narum, David L.

AU - Lopez-Gutierrez, Borja

AU - Hamerly, Timothy

AU - Sacarlal, Jahit

AU - Aguilar, Ruth

AU - Dinglasan, Rhoel R.

AU - Moncunill, Gemma

AU - Izquierdo, Luis

AU - Dobaño, Carlota

PY - 2024

Y1 - 2024

N2 - The RTS,S/AS02A malaria vaccine is based on the Plasmodium falciparum circumsporozoite protein (PfCSP), which is O-fucosylated on the sporozoite surface. We determined whether RTS,S/AS02A-induced immunoglobulin G (IgG) antibodies recognize vaccine-like nonfucosylated PfCSP better than native-like fucosylated PfCSP. Similar to previous vaccine trials, RTS,S/ AS02A vaccination induced high anti-PfCSP IgG levels associated with malaria protection. IgG recognition of nonfucosylated and fucosylated PfCSP was equivalent, suggesting that PfCSP fucosylation does not affect antibody recognition.

AB - The RTS,S/AS02A malaria vaccine is based on the Plasmodium falciparum circumsporozoite protein (PfCSP), which is O-fucosylated on the sporozoite surface. We determined whether RTS,S/AS02A-induced immunoglobulin G (IgG) antibodies recognize vaccine-like nonfucosylated PfCSP better than native-like fucosylated PfCSP. Similar to previous vaccine trials, RTS,S/ AS02A vaccination induced high anti-PfCSP IgG levels associated with malaria protection. IgG recognition of nonfucosylated and fucosylated PfCSP was equivalent, suggesting that PfCSP fucosylation does not affect antibody recognition.

KW - antibodies

KW - circumsporozoite protein (PfCSP)

KW - fucosylation

KW - immunogenicity

KW - malaria

KW - Plasmodium falciparum

KW - RTS,S

U2 - 10.1093/infdis/jiad471

DO - 10.1093/infdis/jiad471

M3 - Journal article

C2 - 37889513

AN - SCOPUS:85187937655

SN - 0022-1899

VL - 229

SP - 795

EP - 799

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 3

ER -