Safety and clinical effect of subcutaneous human interleukin-21 in patients with metastatic melanoma or renal cell carcinoma: a phase I trial

Henrik Schmidt, Janet Brown, Ulrik Mouritzen, Peter Selby, Kirsten Fode, Inge Marie Svane, Graham P Cook, David Hal Mollerup, Poul F Geertsen

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    41 Citationer (Scopus)

    Abstract

    This phase I study in patients with metastatic melanoma (MM) and renal cell carcinoma (RCC) evaluated the safety and maximum tolerated dose (MTD), pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of s.c. treatment of human recombinant interleukin 21 (IL-21).
    OriginalsprogEngelsk
    TidsskriftClinical Cancer Research
    Vol/bind16
    Udgave nummer21
    Sider (fra-til)5312-9
    Antal sider8
    ISSN1078-0432
    DOI
    StatusUdgivet - 1 nov. 2010

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