Saline-induced natriuresis and renal blood flow in conscious dogs: effects of sodium infusion rate and concentration.

N C F Sandgaard; J L Andersen; N-H Holstein-Rathlou; P Bie

doi:10.1111/j.1365-201X.2005.01480.x

Saline-induced natriuresis and renal blood flow in conscious dogs: effects of sodium infusion rate and concentration.

N C F Sandgaard, J L Andersen, N-H Holstein-Rathlou, P Bie

Biomedicinsk Institut

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

9 Citationer (Scopus)

Abstract

Udgivelsesdato: 2005-Nov

Originalsprog	Engelsk
Tidsskrift	Acta Physiologica (Print Edition)
Vol/bind	185
Udgave nummer	3
Sider (fra-til)	237-50
Antal sider	13
ISSN	1748-1708
DOI	https://doi.org/10.1111/j.1365-201X.2005.01480.x
Status	Udgivet - 2005

Bibliografisk note

Keywords: Aldosterone; Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Blood Pressure; Blood Volume; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hematocrit; Homeostasis; Kidney; Models, Animal; Natriuresis; Osmotic Pressure; Ovariectomy; Regional Blood Flow; Saline Solution, Hypertonic; Vascular Resistance

Adgang til dokumentet

10.1111/j.1365-201X.2005.01480.x

Citationsformater

@article{db254ac0ab5f11ddb5e9000ea68e967b,

title = "Saline-induced natriuresis and renal blood flow in conscious dogs: effects of sodium infusion rate and concentration.",

abstract = "AIM: This study focused on static and dynamic changes in total renal blood flow (RBF) during volume expansion and tested whether a change in RBF characteristics is a necessary effector mechanism in saline-induced natriuresis. METHODS: The aortic flow subtraction technique was used to measure RBF continuously. Identical amounts of NaCl (2.4 mmol kg(-1)) were given as slow isotonic (Iso, 120 min), slow hypertonic (Hyper, 120 min), and rapid isotonic loads (IsoRapid, 30 min). RESULTS: During Iso and IsoRapid, arterial blood pressure increased slightly (6-7 mmHg), and during Hyper it remained unchanged. Iso and Hyper increased sodium excretion (4 +/- 1 to 57 +/- 27 and 10 +/- 4 to 79 +/- 28 micromol min(-1), respectively) and decreased plasma renin activity (by 38% and 29%), angiotensin II (by 56% and 58%) and aldosterone (by 47% and 65%), while RBF remained unchanged. IsoRapid caused a similar increase in sodium excretion (to 72 +/- 19 micromol min(-1)), a similar decrease in renin system activity, but a 15% elevation of RBF (282 +/- 22 to 324 +/- 35 mL min(-1)). Selected frequency domain parameters of RBF autoregulation did not change in response to any load. CONCLUSIONS: In response to slow saline loading simulating daily sodium intake, the rate of sodium excretion may increase 10-20-fold without any change in mean arterial blood pressure or in RBF. Regulatory responses to changes in total body NaCl levels appears, therefore, to be mediated primarily by neurohumoral mechanisms and may occur independent of changes in arterial pressure or RBF.",

author = "Sandgaard, {N C F} and Andersen, {J L} and N-H Holstein-Rathlou and P Bie",

note = "Keywords: Aldosterone; Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Blood Pressure; Blood Volume; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hematocrit; Homeostasis; Kidney; Models, Animal; Natriuresis; Osmotic Pressure; Ovariectomy; Regional Blood Flow; Saline Solution, Hypertonic; Vascular Resistance",

year = "2005",

doi = "10.1111/j.1365-201X.2005.01480.x",

language = "English",

volume = "185",

pages = "237--50",

journal = "Acta Physiologica (Print Edition)",

issn = "1748-1708",

publisher = "Wiley-Blackwell",

number = "3",

}

TY - JOUR

T1 - Saline-induced natriuresis and renal blood flow in conscious dogs: effects of sodium infusion rate and concentration.

AU - Sandgaard, N C F

AU - Andersen, J L

AU - Holstein-Rathlou, N-H

AU - Bie, P

N1 - Keywords: Aldosterone; Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Blood Pressure; Blood Volume; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hematocrit; Homeostasis; Kidney; Models, Animal; Natriuresis; Osmotic Pressure; Ovariectomy; Regional Blood Flow; Saline Solution, Hypertonic; Vascular Resistance

PY - 2005

Y1 - 2005

N2 - AIM: This study focused on static and dynamic changes in total renal blood flow (RBF) during volume expansion and tested whether a change in RBF characteristics is a necessary effector mechanism in saline-induced natriuresis. METHODS: The aortic flow subtraction technique was used to measure RBF continuously. Identical amounts of NaCl (2.4 mmol kg(-1)) were given as slow isotonic (Iso, 120 min), slow hypertonic (Hyper, 120 min), and rapid isotonic loads (IsoRapid, 30 min). RESULTS: During Iso and IsoRapid, arterial blood pressure increased slightly (6-7 mmHg), and during Hyper it remained unchanged. Iso and Hyper increased sodium excretion (4 +/- 1 to 57 +/- 27 and 10 +/- 4 to 79 +/- 28 micromol min(-1), respectively) and decreased plasma renin activity (by 38% and 29%), angiotensin II (by 56% and 58%) and aldosterone (by 47% and 65%), while RBF remained unchanged. IsoRapid caused a similar increase in sodium excretion (to 72 +/- 19 micromol min(-1)), a similar decrease in renin system activity, but a 15% elevation of RBF (282 +/- 22 to 324 +/- 35 mL min(-1)). Selected frequency domain parameters of RBF autoregulation did not change in response to any load. CONCLUSIONS: In response to slow saline loading simulating daily sodium intake, the rate of sodium excretion may increase 10-20-fold without any change in mean arterial blood pressure or in RBF. Regulatory responses to changes in total body NaCl levels appears, therefore, to be mediated primarily by neurohumoral mechanisms and may occur independent of changes in arterial pressure or RBF.

AB - AIM: This study focused on static and dynamic changes in total renal blood flow (RBF) during volume expansion and tested whether a change in RBF characteristics is a necessary effector mechanism in saline-induced natriuresis. METHODS: The aortic flow subtraction technique was used to measure RBF continuously. Identical amounts of NaCl (2.4 mmol kg(-1)) were given as slow isotonic (Iso, 120 min), slow hypertonic (Hyper, 120 min), and rapid isotonic loads (IsoRapid, 30 min). RESULTS: During Iso and IsoRapid, arterial blood pressure increased slightly (6-7 mmHg), and during Hyper it remained unchanged. Iso and Hyper increased sodium excretion (4 +/- 1 to 57 +/- 27 and 10 +/- 4 to 79 +/- 28 micromol min(-1), respectively) and decreased plasma renin activity (by 38% and 29%), angiotensin II (by 56% and 58%) and aldosterone (by 47% and 65%), while RBF remained unchanged. IsoRapid caused a similar increase in sodium excretion (to 72 +/- 19 micromol min(-1)), a similar decrease in renin system activity, but a 15% elevation of RBF (282 +/- 22 to 324 +/- 35 mL min(-1)). Selected frequency domain parameters of RBF autoregulation did not change in response to any load. CONCLUSIONS: In response to slow saline loading simulating daily sodium intake, the rate of sodium excretion may increase 10-20-fold without any change in mean arterial blood pressure or in RBF. Regulatory responses to changes in total body NaCl levels appears, therefore, to be mediated primarily by neurohumoral mechanisms and may occur independent of changes in arterial pressure or RBF.

U2 - 10.1111/j.1365-201X.2005.01480.x

DO - 10.1111/j.1365-201X.2005.01480.x

M3 - Journal article

C2 - 16218929

SN - 1748-1708

VL - 185

SP - 237

EP - 250

JO - Acta Physiologica (Print Edition)

JF - Acta Physiologica (Print Edition)

IS - 3

ER -