SAR study of 4-arylazo-3,5-diamino-1: H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms

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Abstract

By screening of a collection of 50 000 small-molecule compounds, we recently identified 4-arylazo-3,5-diamino-1H-pyrazoles as a novel group of anti-biofilm agents. Here, we report a SAR study based on 60 analogues by examining ways in which the pharmacophore can be further optimized, for example, via substitutions in the aryl ring. The SAR study revealed the very potent anti-biofilm compound 4-(2-(2-fluorophenyl)hydrazineylidene)-5-imino-4,5-dihydro-1H-pyrazol-3-amine (2). This journal is

OriginalsprogEngelsk
TidsskriftRSC Medicinal Chemistry
Vol/bind12
Udgave nummer11
Sider (fra-til)1868-1878
Antal sider11
ISSN2040-2503
DOI
StatusUdgivet - 2021

Bibliografisk note

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© The Royal Society of Chemistry.

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